Genetic variation at twentythree microsatellite loci in sixteen human populations

Deka, Ranjan; Shriver, Mark D.; Yu, Ling; Heidreich, Elisa Mueller; Li, Jin; Zhong, Yixi; McGarvey, Stephen T.; Agarwal, S. S.; Bunker, Clareann H.; Miki, Tetsuro; Hundrieser, J.; Yin, Shih‐Jiun; Raskin, Salmo; Barrantes, Ramiro; Ferrell, Robert E.; Chakraborty, Ranajit

doi:10.1007/bf02924561

Cited by 37 publications

(24 citation statements)

References 29 publications

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“…There were no individuals classified as Amerindian or Caucasian by phenotype in this commuStudies in an African-descendant isolate 25 Sources: (1) Africans - (Deka et al, 1999;Destro-Bisol et al, 2000;Huguet et al, 1998;Bosh et al, 2001;Gene et al, 2001;Alves et al, 2001;Brinkmann et al, 1996;Brinkmann et al, 1998;Rolf et al, 1998;Wang et al, 2002;Pérez-Lezaun et al, 1997;Yunis et al, 2000;Corte-Real et al, 2000;Dios et al, 1998); (2) Europeans (Pérez- Lezaun et al, 2000;Anjos et al, 2000;Lourdes-Pontes et al, 1998;Asmundo et al, 1998;Santos et al, 1996;Souto et al, 1996, Souto et al, 1998Alves et al, 2001;Pinheiro et al, 1996;Amorim et al, 1996;Pereira et al, 1996;Gusmão et al, 1997;Espinheira et al, 1996;Miranda et al, 1998;Prata et al, 1998) nity. This date on phenotypic ethnic classification is based on facial morphological characteristics and skin color in body regions not exposed to the sun (Azevêdo, 1980).…”

Section: Resultsmentioning

confidence: 97%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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The African descent population of the Bananal community in the Brazilian state of Bahia (BA) was characterized as a genetic isolate and analyzed for some short tandem repeat (STR) microsatellite autosomic polymorphic loci (CSF1PO, TH01, TPOX, F13A1, FESFPS and vWA). These genetic variants were further compared to data obtained from an urban sample from the town of Jequié (BA) regarding demographic and anthropogenetic aspects. The Bananal sample comprised 32 unrelated individuals whereas Jequié was represented by 76 individuals. The Bananal Negroid Phenotypic Index (NPI) was 0.98 and the Negroid Cultural Index (NCI) 0.24. Consanguineous marriages occurred at a frequency of 34.61% and the F value was 0.0126. All six loci studied were in Hardy-Weinberg Equilibrium (p > 0.05). The genotypic and allele frequencies of the CSF1PO and vWA loci were similar. In the Bananal population the genic diversity of the THO1 locus was 66.8% and that of the F13A1 locus was 83.7%. The estimated ethnic racial admixture was 81% African and 19% Amerindian. The multiple correlation coefficient (R 2 ) indicated adequate adaptation (99%). Total genetic variation for the six loci was 82.9% with an index of 6.7% for population subdivision (G ST ' = 0.067). Anthropologic data and results obtained from the allele frequencies of the loci studied are indicative of a genetic isolate in Bananal, reminiscent of the a`quilombo community' (i.e. one founded by run away slaves).

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Section: Resultsmentioning

confidence: 97%

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

et al. 2006

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“…Some of these loci would have fixed different alleles in different parts of the world, as has been documented (Zerylnick et al 1995, Deka et al 1996, 1999. It could also be the case that they preserve the same alleles in all populations as has been shown for the CSF1R locus (Deka et al 1999). Balancing selection cannot be ruled out given the important role of TP53 in genomic stability (Janus et al 1999), and although the marker screened is located at an intron, increased instability of mRNA from alleles with motifrepeat numbers outside the range observed could affect the normal function of the gene.…”

Section: Discussionmentioning

confidence: 99%

The STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe

Azofeifa

Hahn

Ruiz

et al. 2014

RBT

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Abstract:The STR (AAAAT) n within intron 1 of the TP53 locus was screened in 17 populations from 3 main ethnic groups: Europeans, Asiatics, and Africans, and from the hybrid population of Costa Rica (1968 samples). Three alleles, 126/7 (bp/copies of the repeat), 131/8 and 136/9 were the most prevalent in all populations. Other alleles rarely reached frequencies of 10% or higher. Observed heterozygosities ranged between 0.351 and 0.829. Patterns of diversity fit well with both the geographic origin of the samples and the history of the populations screened. A statistical test suggests that single-step mutational events have been the main mechanism producing new alleles at this locus. Fixation indexes (R ST ) for this marker showed an effect of population subdivision on divergence only within the Asiatic group; they were insensitive at the level of major ethnic groups as well as within Africans and within Europeans. Rev. Biol. Trop. 52(3): 645-657. Epub 2004 Dic 15.

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“…India is a country rich in ethnic, cultural and linguistic variant groups. Although a considerable amount of information on polymorphism at microsatellite loci in humans is now available, but such studies are confined to limited groups [3][4][5][6][7][8][9][10][11][12][13]. Like most other Indians, Sikh is endogamous by caste and exogamous by sub caste [14].…”

Section: Introductionmentioning

confidence: 99%

Population Genetics for Autosomal STR Loci in Sikh Population of Central India

Dogra¹,

Shrivastava²,

Chaudhary³

et al. 2015

Hereditary Genet

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This study is an attempt to generate genetic database for three endogamous populations of Sikh population (Arora, Jat and Ramgariha) of Central India. The analysis of eight autosomal STR loci (D16S539, D7S820, D13S317, FGA, CSF1PO, D21S11, D18S51, and D2S1338) was done in 140 unrelated Sikh individuals. In all the three studied populations, all loci were in Hardy -Weinberg equilibrium except at locus FGA in Ramgariha Sikh and locus D16S539 in Arora Sikh. An analysis of molecular variance (AMOVA) showed 1% variation among the three studied populations. The close genetic relationship between Jat and Ramgariha Sikh population were confirmed in the MDS Plot generated from the pairwise genetic distances.

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Genetic variation at twentythree microsatellite loci in sixteen human populations

Abstract: Background: Major population movements, social structure, and caste endogamy have influenced the genetic structure of Indian populations. An understanding of these influences is increasingly important as gene mapping and case-control studies are initiated in South Indian populations.

Cited by 37 publications

References 29 publications

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

Microsatellite studies on an isolated population of African descent in the Brazilian state of Bahia

The STR polymorphism (AAAAT)n within the intron 1 of the tumor protein 53 (TP53) locus in 17 populations of different ethnic groups of Africa, America, Asia and Europe

Population Genetics for Autosomal STR Loci in Sikh Population of Central India

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