Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy

Jiang, Wen Guo; Liu, Hongliang; Wang, Qiming; Liu, Zhensheng; Li, Yangkai; Xiong, Huihua; Xu, Ting; Wang, Li E.; Gomez, Daniel R.; Mohan, Radhe; Komaki, Ritsuko; Liao, Zhongxing; Wei, Qingyi

doi:10.1016/j.ejca.2014.03.008

Cited by 38 publications

(26 citation statements)

References 34 publications

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“…Indeed, some studies [3–7] and a pooled analysis of 13 studies before 2012 [8] showed older age significantly increased the risk of RILT, but others did not find an association between age and the risk of RILT [9–13]. A study including 369 patients found age (≥70 years) was an independent predictor for both grade ≥ 2 (OR = 1.99) and grade ≥ 3 RP (OR = 8.90) [4].…”

Section: Agementioning

confidence: 99%

Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

Kong

Wang

2015

Seminars in Radiation Oncology

120

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The decision to administer a radical course of radiotherapy is largely influenced by the dose-volume metrics of the treatment plan, but what are the patient related and other factors that may independently increase the risk of radiation lung toxicity? Poor pulmonary function has been regarded as a risk factor and relative contraindication for patients having radical radiotherapy, but recent evidence suggests that patients with poor spirometry may tolerate conventional or high dose radiotherapy as well as, if not better than, patients with normal function. However, caution may need to be exercised in patients with underlying interstitial pulmonary fibrosis. Further there is emerging evidence of molecular markers of increased risk of toxicity. This review will discuss patient related and risk factors other than dosimetry for radiation lung toxicity.

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Section: Agementioning

confidence: 99%

Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

Kong

Wang

2015

Seminars in Radiation Oncology

120

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“…Interestingly, later studies indicated that LIN28B rs314276 C>A polymorphism, which is included in our current study, is associated with timing of puberty [27], growth in height from birth to adulthood [28], finger-length ratio [29], growth in height from birth to adulthood [28], childhood obesity and age at menarche [30], and central precocious puberty and early puberty in girls [31]. Moreover, this variant was also found to be associated with the risk and survival of cancer, such as epithelial ovarian cancer [32], colon cancer [33,34], non-small cell lung cancer [35], oral cavity cancer [36], and neuroblastoma [16]. LIN28B protein was found to be unregulated in colon tumours, and the overexpression correlated with reduced patient survival and increased probability of tumour recurrence [34,37]; besides, LIN28B can promote migration, invasion, and malignant transformation of cells [38].…”

Section: Discussionmentioning

confidence: 99%

Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children

Yang

Zhang

et al. 2016

J Cellular Molecular Medi

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Neuroblastoma is the most commonly diagnosed solid tumour outside the central nervous system in children. However, genetic factors underlying neuroblastoma remain largely unclear. Previous genome‐wide association study indicated that lin‐28 homolog B (LIN28B) might play an important role in the development of neuroblastoma and also contributed to its poor overall survival. With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer‐free controls. Four potentially functional polymorphisms (rs221634 A>T, rs221635 T>C, rs314276 C>A and rs9404590 T>G) were genotyped using Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the associations between the selected single nucleotide polymorphisms (SNPs) and neuroblastoma susceptibility. We also performed genotype‐phenotype association analysis to explore the effects of the selected SNPs on LIN28B gene transcripts. Our results indicated that the rs221634 TT genotype was associated with an increased neuroblastoma risk (TT versus AA/AT: adjusted OR = 1.50, 95% CI = 1.04–2.17). The association was more pronounced in males, patients with tumour of mediastinum origin, as well as patients in early clinical stages. Moreover, overall analysis and stratified analysis also showed an increased risk of neuroblastoma for carrier of the 2–4 risk genotypes. In summary, these results indicated that the LIN28B rs221634 A>T polymorphism was associated with an increased neuroblastoma risk in Southern Chinese children. These findings need further validation in large studies with different ethnicities involved.

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“…Five of these loci were previously reported to have variable association with the risk of single primary colorectal cancer; rs1061624 of TNFRSF1B, rs1059234 of P21, and rs9344 of CCND1 were found to reduce the risk of colorectal cancer and exert protective effects, while rs28362491 of NFKB1 and rs3212986 of ERCC1 increased the risk of colorectal cancer. Among the other 30 loci, five (rs7566, rs887574, rs13035, rs1799757, and rs5343) are reported for the first time in this study, while 25 were associated with malignant tumor development and the response to chemoradiotherapy (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33), inflammatory bowel disease (34), autoimmune diseases (35,36), vitiligo (37), insulin resistance (38), coronary heart disease, stroke, and other types of cardiovascular and cerebrovascular disease (39,40).…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

Cao¹,

Yu²,

Wu³

et al. 2017

Turk J Med Sci

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Background/aim: This study aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) of cancer-related genes and the risk of multiple primary malignancies involving colorectal cancer. Materials and methods:We collected tissue samples from 22 multiple primary cancer patients with primary colorectal cancer and performed genotyping assay for 116 SNP loci from 62 genes encoding peptides functioning in various signaling pathways using the DNA MassARRAY system. The chi-square test was used to compare the differences in base frequencies between patients and a control Chinese population from HapMap through the NCBI database.Results: No significant differences in frequencies were detected for 81 SNPs (P > 0.05), while serious frequency differences were observed for 35 SNPs from 31 genes (P < 0.05), which included ERCC6 (rs2228526), ERCC1 (rs3212986), CASP8 (rs3834129, rs3769818), and others presented. Five of these SNPs were previously reported to be associated with the pathogenesis of colorectal cancer. Conclusion:The 35 SNPs from 31 genes may be associated with the risk of multiple primary malignancies involving colorectal cancer.

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Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy

Cited by 38 publications

References 34 publications

Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

Nondosimetric Risk Factors for Radiation-Induced Lung Toxicity

Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children

Polymorphisms of cancer-related genes and risk of multipleprimary malignancies involving colorectal cancer

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