Potentially functional polymorphisms in the <i><scp>LIN</scp>28B</i> gene contribute to neuroblastoma susceptibility in Chinese children

He, Jing; Yang, Tianyou; Zhang, Ruizhong; Zhu, Jinhong; Wang, Fenghua; Zou, Yan; Xia, Hongmei

doi:10.1111/jcmm.12846

Cited by 43 publications

(32 citation statements)

References 47 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, this variant was also found to be associated with the risk and survival of cancers, such as Wilms tumor [22], neuroblastoma [23] and epithelial ovarian cancer [38]. Previous data also showed that LIN28B rs221634 A>T, rs221635 T>C, and rs9404590 T>G were related to the susceptibility to Wilms tumor [22] and neuroblastoma [23].…”

Section: Discussionmentioning

confidence: 93%

“…For example, LIN28B rs314276 C>A polymorphism has been shown to associate with reproductive timing [33,34], central precocious puberty [35], the linkage between puberty timing and adult disease [36], and the finger-length ratio [37]. Meanwhile, this variant was also found to be associated with the risk and survival of cancers, such as Wilms tumor [22], neuroblastoma [23] and epithelial ovarian cancer [38]. Previous data also showed that LIN28B rs221634 A>T, rs221635 T>C, and rs9404590 T>G were related to the susceptibility to Wilms tumor [22] and neuroblastoma [23].…”

Section: Discussionmentioning

confidence: 99%

“…Most of the genetic variants are single nucleotide polymorphisms (SNPs). LIN28B polymorphisms were associated with Wilms tumor [22] and neuroblastoma [23] susceptibility in Chinese children. However, the relationship of LIN28B polymorphisms with hepatoblastoma susceptibility has not been investigated.…”

Section: Introductionmentioning

confidence: 95%

“…Four LIN28B polymorphisms (rs314276 C>A, rs221634 A>T, rs221635 T>C and rs9404590 T>G) were chosen and genotyped using the TaqMan real-time PCR method as we reported previously [22,23]. Briefly, the selected polymorphisms were all potentially functional SNPs according to SNPinfo online software (https://snpinfo.niehs.nih.gov/ snpinfo/snpfunc.html), which can affect the binding capacity of transcription factor binding sites (rs314276) or microRNA binding sites (rs221634 and rs221635), or leading to amino acids alterations (rs9404590).…”

Section: Snp Selection and Genotypingmentioning

confidence: 99%

See 3 more Smart Citations

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

et al. 2020

Self Cite

View full text Add to dashboard Cite

Hepatoblastoma is one of the malignant liver tumors in children. However, genetic mechanisms underpinning the initiation of hepatoblastoma remain largely unclear. The previous study showed that lin-28 homolog B (LIN28B) might play a role in the development of hepatoblastoma. To detect the association between LIN28B gene polymorphisms and hepatoblastoma risk in Chinese children, we conducted a five-center case-control study of 275 hepatoblastoma patients and 1018 cancer-free controls. Four potentially functional polymorphisms were genotyped using the Taqman method. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the associations. We found that the rs314276 C>A polymorphism (AA vs. CC: adjusted OR=2.05, 95% CI=1.36-3.10, P=0.0006; AA vs. CA/CC: adjusted OR=2.11, 95% CI=1.43-3.12, P=0.0002) and rs9404590 T>G (GG vs. TT: adjusted OR=1.89, 95% CI=1.20-3.00, P=0.007; GG vs. TT/TG: adjusted OR=1.87, 95% CI=1.20-2.92, P=0.006) were associated with increased hepatoblastoma risk. Combination analysis of risk genotypes showed that patients with four risk genotypes had a higher chance of developing hepatoblastoma than carriers of 1 to 3 risk genotypes. Stratification analysis showed the significant association between the rs314276 AA genotype and hepatoblastoma risk in both age and sex groups, as well as clinical stages III+IV cases. The rs9404590 GG genotype was associated with hepatoblastoma risk in participants' ≥17 months, in females, and for those with clinical stages III+IV disease. Furthermore, four risk genotypes confer higher hepatoblastoma susceptibility in both age and sex groups, as well as groups with clinical stages III+IV disease. Genotype-based gene expression analysis confirmed that the rs9404590 T>G polymorphism was significantly associated with altered LIN28B gene expression. We further validated our findings using false-positive probability analysis. This finding suggested that LIN28B gene polymorphisms may be associated with an increased predisposition to hepatoblastoma.

show abstract

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Section: Snp Selection and Genotypingmentioning

confidence: 99%

See 2 more Smart Citations

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…A TIANamp Blood DNA Kit (Centrifugal column, Tiangen) was used to extract DNA from the blood samples according to the manufacturer's instructions . TaqMan real‐time PCR assays were set up in 384‐well plates containing positive and negative samples and were carried out in an ABI Q6 system (Applied Biosystems) to genotype the miRNA‐149 rs2292832 T>C polymorphism …”

Section: Methodsmentioning

confidence: 99%

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

Jiang

et al. 2019

Clinical Laboratory Analysis

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Kawasaki disease (KD), which is characterized by vasculitis, is prone to occur in patients under 5 years of age, has an ambiguous etiology, and displays coronary artery lesions as the chief complication. Previous studies have linked miRNA-149 to cancers, and rs2292832 T>C is related to allergic diseases and inflammatory bowel disease, which both show immune system disorders and coronary artery disease. Therefore, we performed a study concentrating on the association between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility. Methods:The subjects enrolled were 532 children with KD and 623 controls. We used TaqMan real-time PCR to obtain the genotypes of the rs2292832 T>C polymorphism. Results:Ultimately, no significant association was found between the miRNA-149 rs2292832 T>C polymorphism and KD susceptibility, even in stratification analysis. Conclusion:Our results indicated that in southern Chinese patients, the miRNA-149 rs2292832 T>C polymorphism did not affect KD susceptibility, which needs to be further confirmed. K E Y W O R D S Kawasaki disease, miRNA-149, polymorphism S U PP O RTI N G I N FO R M ATI O N Additional supporting information may be found online in the Supporting Information section. How to cite this article: Li J, Wang J, Su X, et al. Association between the miRNA-149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population. J Clin Lab Anal. 2020;34:e23125. https ://doi.

show abstract

The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children

Liu

Zhang

et al. 2017

Clinical Laboratory Analysis

Self Cite

View full text Add to dashboard Cite

show abstract

Potentially functional polymorphisms in the LIN28B gene contribute to neuroblastoma susceptibility in Chinese children

Cited by 43 publications

References 47 publications

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children

Association between the miRNA‐149 rs2292832 T>C polymorphism and Kawasaki disease susceptibility in a southern Chinese population

The correlation between LIN28B gene potentially functional variants and Wilms tumor susceptibility in Chinese children

Contact Info

Product

Resources

About