Genetic variants of the IgA Fc receptor (FcαR, CD89) promoter in chronic hepatitis C patients

Watanabe, Azuma; Shimokawa, Toshibumi; Moriyama, Mitsuhiko; Komine, Fumihiko; Amaki, Shuichi; Arakawa, Yasuyuki; Ra, Chisei

doi:10.1007/s00251-006-0159-5

Cited by 7 publications

(6 citation statements)

References 53 publications

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“…Until now, none of the SNPs were associated with allergy, 52 but altered susceptibility to aggressive periodontitis (324A / G SNP), 48 systemic lupus erythematosus (844A / G SNP), 50 and chronic HCV infection ( − 311T / C and − 142T / C SNPs) have been described. 49 Furthermore, the (844A / G SNP) influences susceptibility to systemic lupus erythematosus, but not systemic sclerosis or rheumatoid arthritis, 50,53 whereas controversy exists for Fc RI polymorphisms in relation to susceptibility to IgA nephropathy. 31,46,54 …”

Section: Reviewmentioning

confidence: 99%

The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

2011

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Immunoglobulin A (IgA) is commonly recognized as the most prevalent antibody (Ab) at mucosal sites with an important role in defense by shielding mucosal surfaces from invasion by pathogens. However, its potential to both actively dampen excessive immune responses or to initiate potent proinflammatory cellular processes is less well known. Interestingly, either functional outcome is mediated through interaction with the myeloid IgA Fc receptor FcαRI (CD89). Monomeric interaction of IgA with FcαRI triggers inhibitory signals that block activation via other receptors, whereas multimeric FcαRI crosslinking induces phagocytosis, reactive oxygen species production, antigen presentation, Ab-dependent cellular cytotoxicity, and cytokine release. Thus, FcαRI acts as a regulator between anti- and proinflammatory responses of IgA. As such, the biology of FcαRI, and its multifaceted role in immunity will be the focus of this review.

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Section: Reviewmentioning

confidence: 99%

The human immunoglobulin A Fc receptor FcαRI: a multifaceted regulator of mucosal immunity

2011

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“…A possible correlation between HCV and IgA nephropathy could be the Fc fragment of IgA receptor (FCAR), which is a human gene coding for cluster of differentiation 89 (CD89). CD89 can trigger IgA-mediated immune responses and may play a role in IgA clearance [ 7 ]. Watanabe, et al investigated if promoter polymorphisms of the FCAR gene could be associated with hepatitis C infection.…”

Section: Discussionmentioning

confidence: 99%

“…They showed that the two genotypes were shown significantly more in these patients compared to 210 healthy control patients. This shows that the FCAR gene coding for CD89 could be associated with chronic hepatitis C infection and progression [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Adult-onset Minimal Change Disease with IgA Nephropathy and Hepatitis C

Chowdhury¹,

Saleem

Lodhi³

et al. 2018

Cureus

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Minimal change disease (MCD) is one of the most common causes of nephrotic syndrome in children, leading to heavy proteinuria and edema. However, it is not as common in adults. Adult-onset minimal change disease with IgA nephropathy is rare. The initial presentation of heavy proteinuria and edema with effacement of podocytes on electron microscopy (EM) should lead the physician to suspect minimal change disease regardless of age. We present a 44-year-old male patient with a history of hepatitis C virus (HCV) who presented with sudden onset of lower extremity edema and 6.6 grams (g) of proteinuria per day.

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“…Three SNPs lie in the promoter and one of these has been reported to be associated with an increased disposition to IgA nephropathy (IgAN) (Tsuge et al, 2001;Jasek et al, 2004), although this association was not seen in another study (Narita et al, 2001). These SNPs may also have an impact on the risk for chronic hepatitis C (Watanabe et al, 2006). An SNP in intron 2 of the FcαRI gene, rs11084377, is associated with differential expression of a truncated soluble form of FcαRI and increased severity of IgAN, although no association between this or three other intronic polymorphisms in FcαRI and IgAN susceptibility was detected (Vuong et al, 2010).…”

Section: Geneticsmentioning

confidence: 95%