2009
DOI: 10.1590/s0004-27302009000200003
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Genetic variants influencing effectiveness of weight loss strategies

Abstract: Body weight excess has an increasingly high prevalence in the world. Obesity is a complex disease of multifactorial origin with a polygenic condition affected by environmental factors. Weight loss is a primary strategy to treat obesity and its morbidities. Weight changes through life depend on the interaction of environmental, behavioral and genetic factors. Interindividual variation of weight loss in response to different types of interventions (behavioral, caloric restriction, exercise, drug or surgery) has … Show more

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Cited by 41 publications
(36 citation statements)
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“…Limited research has demonstrated that the distribution of weight loss at the end of a trial is not normally distributed, shows large variance 20 and that there is a high proportion (30-40%) that may have weight gain 18 . Measuring the variability lends itself mathematically to covariance structure analysis or structural equation modelling of which the growth mixture model is a subtype 21 .…”
Section: Discussionmentioning
confidence: 99%
“…Limited research has demonstrated that the distribution of weight loss at the end of a trial is not normally distributed, shows large variance 20 and that there is a high proportion (30-40%) that may have weight gain 18 . Measuring the variability lends itself mathematically to covariance structure analysis or structural equation modelling of which the growth mixture model is a subtype 21 .…”
Section: Discussionmentioning
confidence: 99%
“…Previous candidate gene studies have identified several genes involved in energy expenditure, appetite control, and lipid metabolism to influence the response to weight loss, with and without interaction with diet or lifestyle [54][55][56]. Of these candidate genes, the PPARG Pro12Ala (rs1801282) has been thoroughly investigated [57,58].…”
Section: Genetic Variation and Dietary Managementmentioning
confidence: 99%
“…The role of the polymorphism of the candidate genes to obesity and its influence on weight loss participate in this process. Despite the interaction of the genotype in the body weight loss, described in studies with twins and family members, it is too early to recommend the use of genotyping for weight loss strategies (12) . When functional capacity in eutrophic women with surplus weight and obese was assessed, there was not significant difference between eutrophic and surplus weight for VO2 max and HAQ-20 scores.…”
Section: Exercise and Endocrine Systemmentioning
confidence: 99%