Genetic variant in 8q24 is associated with prognosis for gastric cancer in a <scp>C</scp>hinese population

Ma, Gaoxiang; Gu, Dongying; Lv, Chunye; Chu, Haiyan; Xu, Zhi; Tong, Na; Wang, Meilin; Tang, Cuiju; Xu, Yong; Zhang, Zhengdong; Wang, Baolin; Chen, Jinfei

doi:10.1111/jgh.12801

Cited by 32 publications

(43 citation statements)

References 42 publications

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“…Additional data support this interaction, for example, Ahmadiyeh et al (2010) suggested that enhancer elements at 8q24 form a longrange chromatin loop with MYC in a tissue-specific manner, while Kim et al (2014) found that the MYC enhancer region physically interacts with the active regulatory region of the long noncoding RNAs CARLo-5 promoter, thus regulating CARLo-5 expression, which is significantly correlated with the rs6983267 allele and increased cancer susceptibility. The association between variants on chromosome 8q24 and gastric cancer has been analyzed in recent reports Wokołorczyk et al, 2008;Guo et al, 2011;Lochhead et al, 2011;Tarleton et al, 2014;Ma et al, 2015). In this regard, Guo et al (2011) found that the GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype in Chinese population.…”

Section: Discussionmentioning

confidence: 95%

“…Particularly, the 8q24 chromosome region has been suspected to contain several cancer risk variants that lead to numerous cancer types, including breast, prostate, thyroid, colorectal and gastric cancer (Easton et al, 2007;Berndt et al, 2008;Ghoussaini et al, 2008;Wokołorczyk et al, 2008Wokołorczyk et al, , 2009Yeager et al, 2009;Turnbull et al, 2010;Von Holst et al, 2010;Guo et al, 2011;Lochhead et al, 2011;Neta et al, 2012;Ma et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Labrador

Torres

Camargo

et al. 2015

Gene

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Labrador

Torres

Camargo

et al. 2015

Gene

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“…This SNP also maps to the intron of a long noncoding RNA (lncRNA), cancer-associated region long noncoding RNAs-1 ( CARLos-1 ). Silico studies have shown that rs10505477 change the CARLos-1 local folding structure, which suggests it may lead to aberrant expression of CARLos-1 [37]. Although the biological function of CARLos-1 is still unclear, the CARLos-5 , which is in the same region with CARLos-1 , has a function in tumor development [38], indicating that CARLos-1 may also play a role in carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese

Tan

Huang

et al. 2016

Oncotarget

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BackgroundRecent genome-wide association studies (GWAS) identified eighteen single-nucleotide polymorphisms (SNPs) to be significantly associated with the risk of colorectal cancer (CRC). However, overall results of the following replications are inconsistent and little is known about whether these associations also exit in colorectal adenomas (CRA).MethodsThe SNP genotyping was performed using a Sequenom MassARRAY to investigate the association of these eighteen SNPs with colorectal neoplasm in a case-control study consisted of 1049 colorectal cancers, 283 adenomas, and 1030 controls.ResultsTwo of these SNPs, rs10505477 and rs719725, showed evidence of an association in both CRC and CRA in our study population. Besides, seven SNPs (rs10808555, rs7014346, rs7837328, rs704017, rs11196172, rs4779584, and rs7229639) were significantly associated with CRC, and another one SNP rs11903757 was over-represented in CRA compared with controls. The strongest association was provided by rs11196172 (OR = 2.02, 95% CI = 1.66 - 2.46, P < 0.0001) and rs11903757 (OR = 1.96, 95% CI = 1.28 - 3.00, P = 0.0026).ConclusionThese results suggest that some previously reported SNP associations also have impact on CRC and CRA predispositions in the Han Chinese population. A part of genetic risk to CRC is possibly mediated by susceptibility to adenomas.

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“…Genome-wide association studies (GWAS) and several case–control studies have proved that some particular variants in CASC8 had correlation with carcinomas such as breast cancer, colorectal cancer (CRC), prostate cancer (pCa), upper gastrointestinal cancer, lung cancer, and gastric cancer 6–10. The single-nucleotide polymorphism (SNP) of rs10505477 – located in the intron of the lncRNA of CASC8 gene – had an intimate correlation with CRC susceptibility,11–13 the risk of lung cancer, the prognosis for gastric cancer,14,6 and so on. Rs7837328 – another polymorphism in CASC8 – was associated with pCa and CRC susceptibility 7,15.…”

Section: Introductionmentioning

confidence: 99%

Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis

Cui

Gao

Yin

et al. 2018

CMAR

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ObjectiveTo explore the relationship between single-nucleotide polymorphisms (SNPs) in one of the long noncoding RNA (lncRNA), cancer susceptibility candidate 8 (CASC8) gene and the risk of cancer.Materials and methodsA meta-analysis was conducted to summarize the relationship between common SNPs (rs10505477 and rs7837328) in the lncRNA CASC8 gene and the risk of cancer. The relevant references were retrieved from several authoritative databases. Rigorous inclusion and exclusion criteria were adopted to ensure the credibility of the results. The fixed effects or random effects model was used to calculate the OR and 95% CI. We tested for publication bias.ResultsFifteen articles containing 20 datasets (24,504 cases and 22,969 controls) were finally included in the meta-analysis. Compared to the individuals carrying the rs10505477 TT genotype, those with the TC or CC genotype had a decreased risk of cancer (TC vs TT: OR 0.876, 95% CI 0.832–0.923, P<0.001; CC vs TT: OR 0.748, 95% CI 0.703–0.795, P<0.001). Allele C of rs10505477 might be a protective factor for decreasing susceptibility to cancer (OR 0.866, 95% CI 0.840–0.893, P<0.001). As for rs7837328, the GA and AA genotypes were associated with increased risks of cancer as compared to the GG genotype (ORs 1.209 and 1.336; 95% CIs 1.127–1.298 and 1.202–1.484, respectively); its A allele could significantly increase the risk of cancer compared with the G allele (OR 1.169, 95% CI 1.114–1.227, P<0.001).ConclusionThe rs10505477 and rs7837328 polymorphisms might be associated with risk of cancer.

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Genetic variant in 8q24 is associated with prognosis for gastric cancer in a Chinese population

Abstract: These findings suggested the SNP rs10505477 may contribute to the survival of gastric cancer and be a potential prognostic biomarker of gastric cancer.

Cited by 32 publications

References 42 publications

Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Association of common variants on chromosome 8q24 with gastric cancer in Venezuelan patients

Risk of eighteen genome-wide association study-identified genetic variants for colorectal cancer and colorectal adenoma in Han Chinese

Association between lncRNA CASC8 polymorphisms and the risk of cancer: a meta-analysis

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