Genetic variability of cloned Cytauxzoon felis ribosomal RNA ITS1 and ITS2 genomic regions from domestic cats with varied clinical outcomes from five states

Pollard, Dana Alicia; Reichard, Mason V.; Cohn, Leah A.; James, Andrea M.; Holman, Patricia J.

doi:10.1016/j.vetpar.2017.08.002

Cited by 13 publications

(14 citation statements)

References 38 publications

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“…C. felis strain may also impact treatment success as one study evaluating the efficacy of atovaquone and azithromycin treatment observed greater treatment success and improved survival in cats infected with C. felis with a specific cytochrome b genotype [ 43 ]; however, other genetic loci were not predictive of treatment success [ 18 ]. While genetic variation among C. felis is described [ 45 , 46 , 47 , 48 ], how virulence or treatment success varies for different C. felis strains/isolates is largely unexplored. Additional studies evaluating genetic differences among cats that survive or succumb to C. felis infection will be needed.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Cytauxzoon felis Infection-Carriers in Eastern Kansas Domestic Cats

et al. 2020

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Cytauxzoon felis is a hemoprotozoal tick-transmitted pathogen of felids. Felids that survive acute disease often remain infected and serve as reservoirs for subsequent tick transmission to other susceptible felines. States adjacent to Kansas have identified C. felis-domestic cat carriers while statewide awareness and concern of cytauxzoonosis have increased. The objective of this study was to determine the prevalence of C. felis-carriers in the eastern Kansas domestic cat population using a sensitive quantitative PCR assay targeting the C. felis Cox3 mitochondrial gene. An overall C. felis infection prevalence of 25.8% was determined for asymptomatic domestic cats in eastern Kansas. Significantly more C. felis-carrier cats were identified in spring and fall, suggesting a seasonal fluctuation of survivors. Additionally, a greater percentage of feral and owned cats were positive for C. felis compared to rescue/rescinded cats. This study demonstrates that C. felis-domestic cat carriers are common among cats that spend at least a portion of time outdoors in eastern Kansas, and that more cats likely survive cytauxzoonosis than expected. Understanding the role of domestic cat carriers of C. felis is essential in developing cytauxzoonosis mitigation strategies, including recommending year-round use of acaricide products for all cats that spend any time outdoors.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Cytauxzoon felis Infection-Carriers in Eastern Kansas Domestic Cats

et al. 2020

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“…This is essential information, because, in canids, different Hepatozoon species can have very different impacts on the health of the host and thus have a different veterinary importance (Vincent-Johnson et al 1997). Similarly, a recent study identified subclinical infections with the haemoparasite Cytauxzoon felis in cats, suggesting the existence of different strains that may vary in pathogenicity, although this link was not identified with the ITS1 genetic loci (Pollard et al 2017). Whether different genetic forms of Hepatozoon in felids have different pathological effects remains unknown, although a fatal infection with H. silvestris has recently been reported in a domestic cat (Kegler et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of Hepatozoon (Apicomplexa) from domestic cats in South Africa, with a global reassessment of Hepatozoon felis diversity

Harris

Halajian

Santos

et al. 2019

J. S. Afr. Vet. Assoc.

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Genetic diversity within partial 18S rRNA sequences from Hepatozoon protozoan parasites from domestic cats in South Africa was assessed and compared against published data to assess global biogeographic patterns. Multiple distinct haplotypes of Hepatozoon felis were identified, as well as an unrelated Hepatozoon lineage. Hepatozoon felis genetic diversity globally is very high, indicating a likely complex of species. The recently described Hepatozoon apri from wild boars is closely related to some lineages of H. felis. Sarcocystis and Babesia parasites were also detected. Since Hepatozoon felis is apparently a species complex, potential differences between genetically distinct forms need to be assessed. The finding of an unrelated Hepatozoon indicates that felids can be infected by more species of Hepatozoon than currently known, and that trophic interactions may increase the number of Hepatozoon species found in carnivores. Genetic screening again is demonstrated to identify previously unrecognised parasites from vertebrate hosts.

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“…Estudos sugerem que não há associação com raça, idade, presença ou ausência de retrovírus ou gênero na infecção por Cytauxzoon spp. nos animais, mas sim, em relação com o acesso ao ambiente externo ao domicílio, próximo ou dentro de áreas com pastagens, com arborização e presença de reservatórios silvestres (Meinkoth et al, 2000;Reichard et al, 2008;Carli et al, 2012;Raghavan et al, 2014).…”

Section: Histórico Da Doença E Epidemiologiaunclassified

“…induza a macrófagos e monócitos infectados a não morrer por apoptose, enquanto os esquizontes se replicam e formam merozoítos infectantes. Podem ocorrer diferentes expressões de genes durante a fase de esquizogonia, o que poderia resultar em diferentes graus de patogenicidades entre as amostras de C. felis (Pollard et al, 2017).…”

Section: Patogeniaunclassified

Infecção por Cytauxzoon spp. em felinos domésticos

et al. 2019

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Cytauxzoon spp. são piroplasmas hemoparasitos que parasitam espécimes da família Felidae. A cytauxzoonose é uma enfermidade caracterizada principalmente por sinais clínicos inespecíficos e súbitos. Tem como reservatórios os felídeos silvestres, no entanto já existem relatos de parasitemia crônica em felinos domésticos. A transmissão ocorre principalmente por vetores como carrapatos na América do Norte; já na América do Sul, Europa e Ásia os vetores são ainda desconhecidos. A patogenia decorre da fase de esquizogonia do parasito em macrófagos que causa obstrução de vasos sanguíneos. O tratamento é baseado nos cuidados de suporte e a combinação terapêutica de atovaquona associada à azitromicina tem demonstrando bons resultados. A profilaxia consiste na restrição do acesso de gatos domésticos em áreas arborizadas que possuam a presença de carrapatos e no uso de repelentes-acaricidas. Com esta revisão de literatura, objetivou-se analisar os aspectos epidemiológicos, clínicos e patológicos que permitam subsidiar o médico veterinário atuar com rapidez em casos suspeitos de cytauxzoonose.

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Genetic variability of cloned Cytauxzoon felis ribosomal RNA ITS1 and ITS2 genomic regions from domestic cats with varied clinical outcomes from five states

Cited by 13 publications

References 38 publications

Prevalence of Cytauxzoon felis Infection-Carriers in Eastern Kansas Domestic Cats

Prevalence of Cytauxzoon felis Infection-Carriers in Eastern Kansas Domestic Cats

Genetic diversity of Hepatozoon (Apicomplexa) from domestic cats in South Africa, with a global reassessment of Hepatozoon felis diversity

Infecção por Cytauxzoon spp. em felinos domésticos

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