Genetic Variability in the Dopamine System (Dopamine Receptor D4, Catechol-O-Methyltransferase) Modulates Neurophysiological Responses to Gains and Losses

Marco-Pallarés, Josep; Cucurell, David; Cunillera, Toni; Krämer, Ulrike M.; Càmara, Estela; Nager, Wido; Bauer, Peter; Schüle, Rebecca; Schöls, Lüdger; Münte, Thomas F.; Rodrı́guez-Fornells, Antoni

doi:10.1016/j.biopsych.2009.01.006

Cited by 83 publications

(84 citation statements)

References 64 publications

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“…4b]. Positive feedback responses also showed an unexpected enhancement of the alpha band power (150-400 ms stimulus onset) that was not found in previous studies that reported EEG spectral power changes to feedback processing (Marco-Pallarès et al, 2008;Marco-Pallarès et al, 2009). The significant interaction of trial type and anterior-posterior (Figs.…”

Section: Time Frequency Analysismentioning

confidence: 68%

“…Thus, previous studies suggest an important role of beta-gamma oscillatory activity in processing important or novel positive information that is required to improve learning or future behavioral adjustments. In addition, a follow-up study showed a potential role of dopamine in this positive reward-related response (Marco-Pallarès et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Brain oscillatory activity associated with task switching and feedback processing

Cunillera

Fuentemilla

Periáñez

et al. 2011

Cogn Affect Behav Neurosci

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100

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In this study, we sought to dissociate eventrelated potentials (ERPs) and the oscillatory activity associated with signals indicating feedback about performance (outcome-based behavioral adjustment) and the signals indicating the need to change or maintain a task set (rule-based behavioral adjustment). With this purpose in mind, we noninvasively recorded electroencephalographic signals, using a modified version of the Wisconsin card sorting task, in which feedback processing and task switching could be studied separately. A similar late positive component was observed for the switch and correct feedback signals on the first trials of a series, but feedbackrelated negativity was observed only for incorrect feedback. Moreover, whereas theta power showed a significant increase after a switch cue and after the first positive feedback of a new series, a selective frontal beta-gamma increase was observed exclusively in the first positive feedback (i.e., after the selection of the new rule). Importantly, for the switch cue, beta-alpha activity was suppressed rather than increased. This clear dissociation between the cue and feedback stimuli in task switching emphasizes the need to accurately study brain oscillatory activity to disentangle the role of different cognitive control processes.

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Section: Time Frequency Analysismentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Brain oscillatory activity associated with task switching and feedback processing

Cunillera

Fuentemilla

Periáñez

et al. 2011

Cogn Affect Behav Neurosci

Self Cite

100

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“…Or, alternatively, norm violation detection may require error processing involving discrepancies between normative expectations and observed behaviors. If so, one might anticipate possible involvement of polymorphic variations in dopamine-system genes (34). Future work along these lines may even reveal how the adaptive task of norm violation might have played a significant role in selecting certain genetic variants in different historical or evolutionary contexts.…”

Section: Discussionmentioning

confidence: 99%

How culture gets embrained: Cultural differences in event-related potentials of social norm violations

Yan

Kitayama

Han

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

165

137

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Humans are unique among all species in their ability to develop and enforce social norms, but there is wide variation in the strength of social norms across human societies. Despite this fundamental aspect of human nature, there has been surprisingly little research on how social norm violations are detected at the neurobiological level. Building on the emerging field of cultural neuroscience, we combine noninvasive electroencephalography (EEG) with a new social norm violation paradigm to examine the neural mechanisms underlying the detection of norm violations and how they vary across cultures. EEG recordings from Chinese and US participants (n = 50) showed consistent negative deflection of event-related potential around 400 ms (N400) over the central and parietal regions that served as a culture-general neural marker of detecting norm violations. The N400 at the frontal and temporal regions, however, was only observed among Chinese but not US participants, illustrating culture-specific neural substrates of the detection of norm violations. Further, the frontal N400 predicted a variety of behavioral and attitudinal measurements related to the strength of social norms that have been found at the national and state levels, including higher culture superiority and self-control but lower creativity. There were no cultural differences in the N400 induced by semantic violation, suggesting a unique cultural influence on social norm violation detection. In all, these findings provided the first evidence, to our knowledge, for the neurobiological foundations of social norm violation detection and its variation across cultures.culture | social norms | N400 | electroencephalography | EEG

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“…The task used was a simplified version of the monetary gambling task [9,14,15]. Each trial began with a fixation cross that remained on the screen for two seconds and was then replaced by two numbers presented in white on black background.…”

Section: Methodsmentioning

confidence: 99%

“…In addition to experimental situations, in which negative feedback stimuli provide critical learning information [11,13] the FRN has also been found in gambling paradigms whenever the participant incurred a monetary loss [9,14,15]. Critically, in these paradigms the participants are given a choice between a larger and a smaller number on which they bet in a lottery-like gamble resulting in either a gain or a loss of a sum of money corresponding to the chosen number.…”

Section: Introductionmentioning

confidence: 99%

When decisions of others matter to me: an electrophysiological analysis

et al. 2010

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BackgroundActions of others may have immediate consequences for oneself. We probed the neural responses associated with the observation of another person's action using event-related potentials in a modified gambling task. In this task a "performer" bet either a higher or lower number and could win or lose this amount. Three different groups of "observers" were also studied. The first (neutral) group simply observed the performer's action, which had no consequences for the observers. In the second (parallel) group, wins/losses of the performer were paralleled by similar wins and losses by the observer. In the third (reverse) group, wins of the performer led to a loss of the observer and vice versa.ResultsERPs of the performers showed a mediofrontal feedback related negativity (FRN) to losses. The neutral and parallel observer groups did similarly show an FRN response to the performer's losses with a topography indistinguishable from that seen in the performers. In the reverse group, however, the FRN occurred for wins of the performer which translated to losses for the observer.ConclusionsTaking into account previous experiments, we suggest that the FRN response in observers is driven by two evaluative processes (a) related to the benefit/loss for oneself and (b) related to the benefit/loss of another person.

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Genetic Variability in the Dopamine System (Dopamine Receptor D4, Catechol-O-Methyltransferase) Modulates Neurophysiological Responses to Gains and Losses

Cited by 83 publications

References 64 publications

Brain oscillatory activity associated with task switching and feedback processing

Brain oscillatory activity associated with task switching and feedback processing

How culture gets embrained: Cultural differences in event-related potentials of social norm violations

When decisions of others matter to me: an electrophysiological analysis

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