Genetic Studies of Complete and Partial Hydatidiform Moles

Lawler, SylviaD.; Pickthall, V J; Fisher, R. A.; Povey, S.; Mj, Evans; Szulman, A. E.

doi:10.1016/s0140-6736(79)91632-5

Cited by 99 publications

(29 citation statements)

References 9 publications

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“…In 1979, the discovery of 2 genetically distinct hydatidiform moles answered a fundamental question of not only molar pathogenesis but also the mechanisms underlying aggressive behavior [1,2]. The complete mole, shown to be derived entirely from the male chromosomes, took center stage as a neoplasm that carried most of the risk of a malignant (choriocarcinoma) outcome [3].…”

Section: Introductionmentioning

confidence: 99%

A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression

Lee¹,

Kim²,

McKeon³

et al. 2007

Human Pathology

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Section: Introductionmentioning

confidence: 99%

A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression

Lee¹,

Kim²,

McKeon³

et al. 2007

Human Pathology

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“…Numerous risk factors for molar pregnancies have been suggested, including paternal age, 56 maternal genetic anomalies, 57 blood group, 58 oral contraceptives, 59 maternal age 60 and environmental factors; in particular vitamin A and the folates. 61 However, the only clear data is related to maternal age 39 and the previous occurrence of a prior molar pregnancy.…”

Section: Epigenetic Factorsmentioning

confidence: 99%

The hydatidiform mole

Candelier

2016

Cell Adhesion & Migration

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The hydatidiform mole (HM) is a placental pathology of androgenetic origin. Placental villi have an abnormal hyperproliferation event and hydropic degeneration. Three situations can be envisaged at its origin: 1. The destruction/expulsion of the female pronucleus at the time of fertilization by 1 or 2 spermatozoa with the former being followed by an endoreplication of the male pronucleus leading to a complete hydatidiform mole (CHM) 2. A triploid zygote (fertilization by 2 spermatozoa) leading to a partial hydatidiform mole (PHM) but can also lead to haploid and diploid clones. The diploid clone may produce a normal fetus while the haploid clone after endoreplication generates a CHM 3. A nutritional defect during the differentiation of the oocytes or the deterioration of the limited oxygen pressure during the first trimester of gestation may lead to the formation of a HM.In countries with poor medical health care system, moles (mainly the CHM) can become invasive or, in rare cases, lead to gestational choriocarcinomas.

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“…It occurs as a result of fertilisation of an empty egg devoid of maternal chromosomes by a single spermatozoon (in most cases) that duplicates its 23,X chromosomal content to produce 46,XX, or by two spermatozoa (about 25% of cases) to produce a dispermic 46,XX or 46,XY conceptus. [3][4][5][6] Partial mole is characterised by two groups of chorionic villi, one being normal in size and the other showing hydropic swelling which is often focal. Villous capillaries containing nucleated fetal red blood cells are usually present.…”

mentioning

confidence: 99%

Interphase cytogenetic and AgNOR analyses of hydatidiform moles.

et al. 1998

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Aim-To determine the potential value of interphase cytogenetic and argyrophilic nucleolar organiser region (AgNOR) analyses in the diagnosis and classification of hydatidiform moles. Methods-Serial tissue sections from 37 hydatidiform moles, histologically classified as 11 complete and 15 partial, and from 11 hydropic abortuses were examined by in situ hybridisation using digoxigenin labelled probes specific for chromosomes 1, X, and Y, and a one step silver staining method. The percentages of diploid and triploid nuclei, and the mean number of AgNORs for each tissue were determined. Results-Interphase cytogenetics showed that eight of the 11 cases (73%) each of complete mole and hydropic abortus had diploid pattern and the three remaining cases (27%) of each group were triploid. Two of the triploid complete moles and one of the triploid hydropic abortuses were revised to partial moles and one remaining triploid complete mole was revised to hydropic abortus. Of the 15 partial moles, nine (60%) were triploid, and six (40%) were diploid. These diploid cases were revised to three complete moles and three hydropic abortuses. There was a significant diVerence (p < 0.0001) between the mean (SD) AgNOR count in partial mole (5.11 (0.91)) versus hydropic abortus (3.79 (0.90)) and complete mole (3.39 (0.97)). The total of 15 triploid cases showed a high mean AgNOR count of 5.24 (0.73). Also, after reclassification, eight of the nine partial moles (89%) had a mean AgNOR count of > 5. The results of analyses by the two methods were closely correlated. Conclusions-Interphasecytogeneticanalysis using chromosome specific probes and AgNOR count provides a valuable approach for ploidy analysis in histological sections of hydatidiform moles and helps to resolve diYcult cases. (J Clin Pathol 1998;51:438-443)

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Genetic Studies of Complete and Partial Hydatidiform Moles

Cited by 99 publications

References 9 publications

A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression

A unifying concept of trophoblastic differentiation and malignancy defined by biomarker expression

The hydatidiform mole

Interphase cytogenetic and AgNOR analyses of hydatidiform moles.

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