Genetic Selection and Differential Stress Responses: The Roman Lines/Strains of Rats

Driscoll, Peter; Escorihuela, Rosa M.; Fernández-Teruel, Albert; Giorgi, Osvaldo; Schwegler, Herbert; Steimer, Thierry; Wiersma, A.; Corda, Maria Giuseppa; Flint, Jonathan; Koolhaas, Jaap M.; Langhans, Wolfgang; Schulz, Pierre; Siegel, Jerome H.; Tobeña, Adolf

doi:10.1111/j.1749-6632.1998.tb09029.x

Cited by 133 publications

(91 citation statements)

References 33 publications

(58 reference statements)

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“…They were bred at the Autonomous University of Barcelona (Spain) from colonies established in 1997 (Driscoll et al, 1998;Escorihuela et al, 1997Escorihuela et al, , 1999. Although the literature refers to gender differences in the expression of impulsive behavior, we used female rats in the present experiments because the behavioral traits that distinguish the Roman lines have been consistently confirmed in both sexes across several laboratories and along different generations (Aguilar et al, 2003;Corda et al, 2005;Ferre et al, 1995;Rosas et al, 2007).…”

Section: Animalsmentioning

confidence: 99%

“…In all of these situations and in fear-conditioning procedures (eg, fear-potentiated startle; López-Aumatell et al, 2009a), RLA rats show increased anxiety or fear, a passive coping style, and increased stress responses by hypothalamus-pituitaryadrenal (HPA) axis activation (Carrasco et al, 2008;Steimer and Driscoll, 2003). RHA rats tend to be novelty/sensation seekers with relatively low HPA axis activation (Driscoll et al, 1998(Driscoll et al, , 2009. Moreover, these differences occur with individual differences in vulnerability to drug addiction, manifested as behavioral and neurochemical responses to different drugs of abuse such as ethanol, morphine, and cocaine (Fattore et al, 2009;Giorgi et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

“…Two phenotypes with different emotional and motivational profiles have been developed through bidirectional selection and breeding of the Roman high-(RHA) and low-avoidance (RLA) rat lines/ strains (outbred or inbred, respectively), selected for rapid (RHA) vs extremely poor (RLA) acquisition of two-way active avoidance in the shuttle-box (Broadhurst and Bignami, 1965;Driscoll and Bättig, 1982) (for reviews, see Driscoll et al, 1990Driscoll et al, , 1998Driscoll et al, , 2009Escorihuela et al, 1995Escorihuela et al, , 1999Fernández-Teruel et al, 1997;Giorgi et al, 2007;Steimer and Driscoll, 2005). These lines/strains show consistent differences in sensation/novelty seeking and in stress/anxiety endocrine and behavioral responses when confronted with novel environments (ie, intended to measure anxiety, emotionality, fearfulness, or novelty seeking), such as the open-field test (Aubry et al, 1995;Carrasco et al, 2008;Escorihuela et al, 1999;Gentsch et al, 1991), elevated plus maze (Escorihuela et al, 1999;Steimer and Driscoll, 2003), elevated zero-maze (López-Aumatell et al, 2009b), blackwhite box test, dark-light open-field test, dark-light hexagonal tunnel maze (Fernández-Teruel et al, 2002b;Steimer and Driscoll, 2005), and hole-board test (Escorihuela et al, 1999;Fernández-Teruel et al, 1992).…”

Section: Introductionmentioning

confidence: 99%

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Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

131

106

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The selective breeding of Roman high-(RHA) and low-avoidance (RLA) rats for rapid vs extremely poor acquisition of active avoidance behavior in a shuttle-box has generated two phenotypes with different emotional and motivational profiles. The phenotypic traits of the Roman rat lines/strains (outbred or inbred, respectively) include differences in sensation/novelty seeking, anxiety/fearfulness, stress responsivity, and susceptibility to addictive substances. We designed this study to characterize differences between the inbred RHA-I and RLA-I strains in the impulsivity trait by evaluating different aspects of the multifaceted nature of impulsive behaviors using two different models of impulsivity, the delay-discounting task and five-choice serial reaction time (5-CSRT) task. Previously, rats were evaluated on a schedule-induced polydipsia (SIP) task that has been suggested as a model of obsessive-compulsive disorder. RHA-I rats showed an increased acquisition of the SIP task, higher choice impulsivity in the delay-discounting task, and poor inhibitory control as shown by increased premature responses in the 5-CSRT task. Therefore, RHA-I rats manifested an increased impulsivity phenotype compared with RLA-I rats. Moreover, these differences in impulsivity were associated with basal neurochemical differences in striatum and nucleus accumbens monoamines found between the two strains. These findings characterize the Roman rat strains as a valid model for studying the different aspects of impulsive behavior and for analyzing the mechanisms involved in individual predisposition to impulsivity and its related psychopathologies.

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Section: Animalsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Moreno

Cardona

Gómez

et al. 2010

Neuropsychopharmacol

131

106

View full text Add to dashboard Cite

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“…Therefore, a deeper knowledge of the neurobiological mechanisms underlying normal and pathological emotionality may result in improved therapeutic approaches. Since humans suffering from psychiatric disorders are not easily accessible for neurobiological studies, several animal models have been developed to mimic psychopathological conditions (Overstreet et al, 1992;Driscoll et al, 1998;Escorihuela et al, 1999). Over the past few decades, two Wistar rat lines have been bred in our laboratory for extremes in high (HAB) or low (LAB) anxiety-related behavior on the elevated plus-maze (EPM) and were now established as a novel animal model of trait anxiety/ depression (for a review, see Landgraf andWigger, 2002, 2003).…”

Section: Introductionmentioning

confidence: 99%

Alterations in Central Neuropeptide Expression, Release, and Receptor Binding in Rats Bred for High Anxiety: Critical Role of Vasopressin

Wigger

Sánchez

Mathys

et al. 2003

Neuropsychopharmacol

238

152

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To model aspects of trait anxiety/depression, Wistar rats were bred for extremes in either hyper (HAB)-or hypo(LAB)-anxiety as measured on the elevated plus-maze and in a variety of additional behavioral tests. Similar to psychiatric patients, HAB rats prefer passive stress-coping strategies, indicative of depression-like behavior, show hyper-reactivity of the hypothalamo-pituitary-adrenal axis, and a pathological response to the dexamethasone/corticotropin-releasing hormone (CRH) challenge test. Here we tested central mRNA expression, release patterns, and receptor binding of neuropeptides critically involved in the regulation of both anxiety-related behavior and the HPA axis. Thus, CRH, arginine-8-vasopressin (AVP), and oxytocin (OXT) were studied in brains of HAB and LAB males both under basal conditions and after exposure to a mild emotional stressor. In HAB rats, CRH mRNA was decreased in the bed nucleus of the stria terminalis only. While no significant difference in CRH1-receptor binding was found in any brain area, CRH2-receptor binding was elevated in the hypothalamic paraventricular nucleus (PVN), the ventromedial hypothalamus, and the central amygdala of HABs compared to LABs. AVP, but not OXT, mRNA expression as well as release of the neuropeptide, were higher in the PVN of HABs, whereas AVP V1a-receptor binding failed to show significant differences in any brain region studied. Remarkably, intra-PVN treatment of HABs with the AVP V1-receptor antagonist d (CH 2 ) 5 Tyr (Me) AVP resulted in a decrease in anxiety/depression-related behavior. The elevated expression and release of AVP within the PVN of HAB rats together with the behavioral effects of the AVP V1-receptor antagonist suggest a critical involvement of this neuropeptide in neuroendocrine and behavioral phenomena associated with trait anxiety/ depression.

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“…Furthermore, all those factors are linked to a genetic basis for the expression of behavioural and physiological components of individual coping categories, proactive and reactive (Driscoll et al, 1998;Koolhaas et al, 2010). For example, the scale of the cortisol response to stress is an individual characteristic which is stable over time in rainbow trout, with high degree of heritability (Pottinger and Carrick, 1999).…”

Section: Introductionmentioning

confidence: 99%

Reproduction, olfaction and dominance behaviour in Senegalese sole (Solea senegalensis)

Fernández¹

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Genetic Selection and Differential Stress Responses: The Roman Lines/Strains of Rats

Cited by 133 publications

References 33 publications

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Impulsivity Characterization in the Roman High- and Low-Avoidance Rat Strains: Behavioral and Neurochemical Differences

Alterations in Central Neuropeptide Expression, Release, and Receptor Binding in Rats Bred for High Anxiety: Critical Role of Vasopressin

Reproduction, olfaction and dominance behaviour in Senegalese sole (Solea senegalensis)

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