Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers

Koshmanova, Ekaterina; Muto, Vincenzo; Chylinski, Daphné; Mouraux, Charlotte; Reyt, Mathilde; Grinard, Martin; Talwar, Puneet; Lambot, Erik; Berthomier, Christian; Brandewinder, Marie; Mortazavi, Nasrin; Degueldre, Christian; Luxen, André; Salmon, Éric; Georges, Michel; Collette, Fabienne; Maquet, Pierre; Someren, Eus J.W. Van; Vandewalle, Gilles

doi:10.1016/j.nbd.2022.105924

Cited by 5 publications

(4 citation statements)

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“…On a broader note, these results demonstrate that subjective experience of sleep and objective sleep are at least partly genetically independent and also point toward a limited applicability of actigraphy in the context of insomnia disorder. Another polygenic risk study (Koshmanova et al, 2022), however, strongly supports the idea that polygenic propensity for insomnia is associated with objective indicators of suboptimal sleep quality, that is less deep sleep (slow-wave sleep) as measured with polysomnography. The genetic propensity for insomnia is thus persistent, and insomnia may be lifelong trait, unlikely to be learned later in life.…”

Section: Discussionmentioning

confidence: 89%

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

2024

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Section: Discussionmentioning

confidence: 89%

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

2024

View full text Add to dashboard Cite

show abstract

“…On a broader note, these results demonstrate that subjective experience of sleep and objective sleep are at least partly genetically independent and also point toward a limited applicability of actigraphy in the context of insomnia disorder. Another polygenic risk study (Koshmanova et al., 2022), however, strongly supports the idea that polygenic propensity for insomnia is associated with objective indicators of suboptimal sleep quality, that is less deep sleep (slow‐wave sleep) as measured with polysomnography. The genetic propensity for insomnia is thus persistent, and insomnia may be lifelong trait, unlikely to be learned later in life.…”

Section: Discussionmentioning

confidence: 91%

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

Kocevska,

Trajanoska,

Mulder

et al. 2023

Child Psychology Psychiatry

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BackgroundTwin studies show moderate heritability of sleep traits: 40% for insomnia symptoms and 46% for sleep duration. Genome‐wide association studies (GWAS) have identified genetic variants involved in insomnia and sleep duration in adults, but it is unknown whether these variants affect sleep during early development. We assessed whether polygenic risk scores for insomnia (PRS‐I) and sleep duration (PRS‐SD) affect sleep throughout early childhood to adolescence.MethodsWe included 2,458 children of European ancestry (51% girls). Insomnia‐related items of the Child Behavior Checklist were reported by mothers at child's age 1.5, 3, and 6 years. At 10–15 years, the Sleep Disturbance Scale for Children and actigraphy were assessed in a subsample (N = 975). Standardized PRS‐I and PRS‐SD (higher scores indicate genetic susceptibility for insomnia and longer sleep duration, respectively) were computed at multiple p‐value thresholds based on largest GWAS to date.ResultsChildren with higher PRS‐I had more insomnia‐related sleep problems between 1.5 and 15 years (BPRS‐I < 0.001 = .09, 95% CI: 0.05; 0.14). PRS‐SD was not associated with mother‐reported sleep problems. A higher PRS‐SD was in turn associated with longer actigraphically estimated sleep duration (BPRS‐SD < 5e08 = .05, 95% CI: 0.001; 0.09) and more wake after sleep onset (BPRS‐SD < 0.005 = .25, 95% CI: 0.04; 0.47) at 10–15 years, but these associations did not survive multiple testing correction.ConclusionsChildren who are genetically predisposed to insomnia have more insomnia‐like sleep problems, whereas those who are genetically predisposed to longer sleep have longer sleep duration, but are also more awake during the night in adolescence. This indicates that polygenic risk for sleep traits, based on GWAS in adults, affects sleep already in children.

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“…3 Beyond the behaviors that do not favor appropriate sleep, some people are more vulnerable to poor sleep or more at risk of developing insomnia. 4,5 The biological origin of sleep variability is however not fully established. 6 The locus coeruleus (LC), a small 1.5cm-long spaghetti-shaped nucleus of the dorsal pons, 7 produces norepinephrine (NE) as a part of the ascending arousal system and projects to the neocortex, hippocampus, amygdala, thalamus, and cerebellum.…”

Section: Introductionmentioning

confidence: 99%

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness

Mortazavi,

Talwar,

Koshmanova

et al. 2024

Preprint

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ObjectiveAnimal studies established that the locus coeruleus (LC) plays important roles in sleep and wakefulness regulation. Whether it contributes to sleep variability in humans is not yet established. Here, we investigated if thein vivoactivity of the LC is related to the variability in the quality of Rapid Eye Movement (REM) sleep.MethodsWe assessed the LC activity of 34 healthy younger (∼22y) and 18 older (∼61y) individuals engaged in bottom-up and top-down cognitive tasks using 7-Tesla functional Magnetic Resonance Imaging (fMRI). We further recorded their sleep electroencephalogram (EEG) to evaluate associations between LC fMRI measures and REM sleep EEG metrics.ResultsTheta oscillation energy during REM sleep was positively associated with LC response in the top-down task. In contrast, REM sleep theta energy was negatively associated with LC activity in older individuals during the bottom-up task. Importantly, sigma oscillations power immediately preceding a REM sleep episode was positively associated with LC activity in the top-down task.InterpretationLC activity during wakefulness was related to REM sleep intensity and to a transient EEG change preceding REM sleep, a feature causally related to LC activity in animal studies. The associations depend on the cognitive task, suggesting that a balanced level of LC tonic activity during wakefulness is required for optimal expression of REM sleep. The findings may have implications for the high prevalence of sleep complaints reported in aging and for disorders such as insomnia, Alzheimer’s, and Parkinson’s disease, for which the LC may play pivotal roles through sleep.

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Genetic risk for insomnia is associated with objective sleep measures in young and healthy good sleepers

Cited by 5 publications

References 50 publications

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

Are some children genetically predisposed to poor sleep? A polygenic risk study in the general population

REM sleep quality is associated with balanced tonic activity of the locus coeruleus during wakefulness

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