Genetic regulation of the MMP-7 and MMP-12 gene expression

Jormsjö, Sofia; Ye, Shu; Moritz, Joseffa; Burt, Barbro; Henney, Adriano; Hamsten, Anders; Eriksson, Per

doi:10.1016/s0021-9150(00)80722-4

Cited by 2 publications

(2 citation statements)

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“…[37] found a correlation between decrease of SM -1 and SM -2 marker expression and increase in PDGF and MIM -3/ 9 expression in the rabbit neointima. Knoockout gene studies for MMP -9 have demonstrated decreased intimal SMC hyperplasia and reduced late lumen loss in the mouse carotid artery flow cessation model [38] and in the carotid wire injury model [39]. During the natural progression of atherosclerosis in APOE -1-mice, differential expression of MMP -9 increases with time in lesional areas versus nonlesion areas [40].…”

Section: Ecm Depositionmentioning

confidence: 99%

Vascular Smooth Muscle Cells and the Comparative Pathology of Atherosclerosis

Al-Sadi¹

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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Section: Ecm Depositionmentioning

confidence: 99%

Vascular Smooth Muscle Cells and the Comparative Pathology of Atherosclerosis

Al-Sadi¹

2012

Current Basic and Pathological Approaches to the Function of Muscle Cells and Tissues - From Molecules to Humans

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“…These are proteolytic enzymes known as the matrix metalloproteinases (MMP). These proteins are classified into several subgroups according to their substrate specificity and include collagenases, like MMP-1 (49,50) and MMP-13 (35,49,51), gelatinases, like MMP-9 (49), elastase, MMP-12 (52), and stromelysins, like MMP-3 (49,50). All are produced by the intimal macrophages including the mature foam cells (53).…”

Section: Introductionmentioning

confidence: 99%

Macrophage Death and the Role of Apoptosis in Human Atherosclerosis

Hegyi

Hardwick

Siow

et al. 2001

Journal of Hematotherapy & Stem Cell Research

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The arterial disease atherosclerosis is responsible for severe morbidity and is the most common cause of death in the Western population. The complete pathogenesis of the disease is unknown, but multiple risk factors have been identified that correlate with the development of its complications such as heart attack and stroke. Evidence suggests that atherosclerosis is an inflammatory disease and the major cell types involved are smooth muscle cells, macrophages, and T lymphocytes. In this paper, we review the function of macrophages in the context of atherosclerosis and we also discuss the role and significance of macrophage death, including apoptosis. There is much evidence, certainly in vitro, suggesting that low-density lipoprotein becomes atherogenic when it undergoes cell-mediated oxidation within the artery wall. Besides inducing apoptosis in vitro, oxidized low-density lipoprotein may also cause extensive DNA damage in intimal cells, which might presage apoptosis. We review the results of experimental and clinical studies, which may indicate how the complications of atherosclerosis could be prevented by using different therapeutical strategies including bone marrow transplantation and gene therapy.

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Genetic regulation of the MMP-7 and MMP-12 gene expression

Cited by 2 publications

References 0 publications

Vascular Smooth Muscle Cells and the Comparative Pathology of Atherosclerosis

Vascular Smooth Muscle Cells and the Comparative Pathology of Atherosclerosis

Macrophage Death and the Role of Apoptosis in Human Atherosclerosis

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