Genetic regulation of the Host's response to injection of Mycobacterium bovic (BCG) and Mycobacterium tuberculosis H37RV

Никоненко, Б. В.; Mezhlumova, M. B.; Moroz, A. M.

doi:10.1007/bf00841320

Cited by 3 publications

(5 citation statements)

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“…Earlier we have shown that mice of CBA/N strain have intermediate susceptibility to primary tuberculosis infection, like several other strains. However, unlike most mouse strains tested, CBA/N has shown a negligible increment of MST and no increase of DTH response after BCG vaccination [20]. These data suggest that CBA/N mice could serve as an experimental model to study distinct genetic control of the BCG protective effect and resistance to primary tuberculosis.…”

Section: Discussionmentioning

confidence: 87%

“…In order to determine if the low level of response to mycobacterial antigens observed earlier in the DTH reaction [20] is characteristic of the CBA/N strain in general, we studied the in vitro proliferation of lymph node cells from BCG-vaccinated CBA/N and CBA mice in the presence of PPD and H37Rv sonicate. As shown in Table 3a, the proliferative capacity of CBA/N lymphocytes was lower than that of CBA cells in the presence of PPD (P To study whether the difference in response was determined by APC or by T cells from two mouse strains, we performed coculture experiments.…”

Section: Proliferative Response Of Cba/n and Cba Lymph Node Cellsmentioning

confidence: 99%

“…Earlier we have shown that CBA/N (xid ) mice, being relatively resistant to primary H37Rv tuberculosis infection, do not increase their MST and express an exceptionally low level of the DTH response to tuberculin after subcutaneous vaccination with BCG and subsequent H37Rv infection, unlike the vast majority of inbred mouse strains [20]. Nothing is known about cellular mechanisms of antituberculosis defence affected by xid mutation.…”

Section: Introductionmentioning

confidence: 96%

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Influence of the mouse Bcg Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette–Guérin (BCG) vaccination

Никоненко

Apt

Mezhlumova

et al. 1996

Clinical and Experimental Immunology

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SUMMARYWe have studied the role of three mouse distinct non-H-2 genes (Bcg, Tbc-1, xid ) in several phenomena of antituberculosis immunity and resistance. On the basis of median survival time (MST) of mice following infection with virulent Mycobacterium tuberculosis H37Rv, Bcg gene did not control resistance to the lethal dose of H37Rv infection in non-vaccinated and Myco. bovis (BCG)-vaccinated mice. However, Bcg r allele, in comparison with Bcg s allele, determined more effective suppression of an early multiplication in spleens of H37Rv mycobacteria after a low dose (5 2 10 4 colony-forming units (CFU)) injection. CBA/N mice, which are not protected efficiently against tuberculous challenge by BCG vaccination, were characterized by a decreased in vitro proliferation of immune lymph node cells, both spontaneous and stimulated with mycobacterial antigens. The decreased proliferation was due to immunosuppression caused by interactions between responding T cells and CBA/N antigen-presenting cells (APC). We have confirmed that the defective response to BCG-vaccination in CBA/N mice is linked with the X-chromosome and thus is presumably determined by the xid gene itself. I/St mice (Tbc-1 s ), supersusceptible to H37Rv infection, were not able to restrict the growth of H37Rv mycobacteria in spleens, even following infection with a low dose (5 2 10 4 ), but restricted the growth of Myco. bovis BCG more effectively than Bcg s mice.

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Section: Discussionmentioning

confidence: 87%

Section: Proliferative Response Of Cba/n and Cba Lymph Node Cellsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Influence of the mouse Bcg Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette–Guérin (BCG) vaccination

Никоненко

Apt

Mezhlumova

et al. 1996

Clinical and Experimental Immunology

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“…The genetic control of baeillc Calmette-Gucrin (BCG)-induced protection to tuberculosis represents another major problem yet to be addressed. Earlier we showed that the efficacy of BCG vaccination differs dramatically in CBA and CBA/N-.v/f/ mice, whereas susceptibility to primary infeetion does not ( [27], and unpublished), and in this paper we studied the role of the H-2 comptex regulating protection and the DTH response in infeeted and vaccinated/infected H-2 congenic mice. We have also compared in susceptible and resistant H-2 eongenic mice T cell proliferation and antibody response to SDS-PAGE-separated myeobacterial antigens.…”

Section: Introductionmentioning

confidence: 90%

DistinctH-2complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice

Апт

Авдиенко

Никоненко

et al. 1993

Clinical and Experimental Immunology

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SUMMARYWe have studied the impact of distinct haplotypes and of difTerent alleles at specific H-2 loci on: (i) the susceptibility to lethal form of experimental tubereulosis; (ii) the level of DTH to mycobaclerial antigens; (iii) the efficacy of vaccination wilh bacille Calmette-Gucrin (BCG); and (iv) the IgG production and Tcell proliferative response to H37Rv antigens. On lhe basis of median survival lime (MST) following primary inoculation wilh lethal dose of Myeobaeterium tutwrcidosis, susceptibility to infection associated with I-A'' and // alleles. host resistance associaled with /-/I* and D'' alleles. Mice bearing a disease-resistant phenotype also developed a vigorous DTH response. Vaccination with BCG before H37Rv infection significantly prolonged the .survival time of both resistant and susceptible animals, except in BIO.M (H-2') mice. The latter exhibited intermediate resistance to infection before but slight decrease in lhe MST following a high-dose BCG vaccination. Distinct H-2 regulation of su.sceptibility to lethal infection and of BCG vaccination efiicacy was confirmed in another relatively resistant //-^'-bearing strain A.CA,, in which mortality occurred more rapidly in vaccinated compared with primarily infected animals. The expression of the H-2' haplotype was associated wilh a low DTH response to tuberculin following vaccination and subsequent lethal infection. The lack of BCG protection against Myco. tubercutosis QhaWcnofi'uy BIO.M mice associated with the high titre of specific IgG, In addilion, these mice exhibited a unique ability to respond to65-kD aniigen by both IgG synthesis and T cell proliferation.

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“…tuberculosis H37Rv strain [1][2][3]6,7]. The protective effect is mediated mainly by T-cells and activated macrophages [7,11,12].…”

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confidence: 99%

Immunological memory induced byMycobacterium bovis in inbred mice

et al. 1997

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Immunological memory was reproduced and studied by subcutaneous vaccination of mice with attenuated strain of Mycobacterium bovis. Ionomycin-resistant cells of CBA mice were for the first time isolated from immune cells and studied as memory T-cells. Previously they were described for another experimental model. They are characterized by high expression of CD3, CD4, CD8, CD28, and ~/13-T-cell receptor. The capacity of splenocytes and ionomycin-resistant cells to adoptive transfer of antituberculosis resistance to intact recipients is studied.

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Genetic regulation of the Host's response to injection of Mycobacterium bovic (BCG) and Mycobacterium tuberculosis H37RV

Cited by 3 publications

References 4 publications

Influence of the mouse Bcg Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette–Guérin (BCG) vaccination

Influence of the mouse Bcg Tbc-1 and xid genes on resistance and immune responses to tuberculosis infection and efficacy of bacille Calmette–Guérin (BCG) vaccination

DistinctH-2complex control of mortality, and immune responses to tuberculosis infection in virgin and BCG-vaccinated mice

Immunological memory induced byMycobacterium bovis in inbred mice

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