Genetic Profile and Secretome of Adipocytes From Visceral and Subcutaneous Adipose Tissue in Patients With Cardiovascular Diseases

Синицкий, М. Ю.; Понасенко, А. В.; Груздева, О. В.

doi:10.17802/2306-1278-2017-6-3-155-165

Cited by 8 publications

(5 citation statements)

References 35 publications

(45 reference statements)

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“…В обеих группах обнаружили и прямую корреляционную связь между ИВО и апо В -наиболее атерогенным аполипопротеином, повышенный уровень которого играет существенную роль в развитии атеросклеротического поражения. Такие результаты представляют интерес, поскольку ранее сообщалось, что повышение концентрации апо В ассоциируется с повышенным риском смертельного ИМ, а снижение его уровня в сыворотке крови приводит к уменьшению воспаления и инсулинорезистентности [14,15].…”

Section: Discussionunclassified

Visceral adiposity index in patients with coronary artery disease, obesity and type 2 diabetes

Хорлампенко

Каретникова

Кочергина

et al. 2020

Cardiovasc Ther Prev

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Aim. To assess visceral adiposity index (VAI) in patients with coronary artery disease (CAD) and overweight or obesity, as well as to determine its relationship with lipid and carbohydrate metabolism parameters and inflammatory markers, depending on the presence of carbohydrate metabolism disorders (CMD).Material and methods. The study included 95 patients with CAD and overweight (body mass index (BMI) >25 kg/m2) or obesity (BMI >30 kg/m2), of which 59 patients had type 2 diabetes (T2D) and 36 were without CMD. All patients were assessed for obesity; VAI was calculated. Following laboratory parameters were evaluated: glucose, glycated hemoglobin, C-reactive protein, adiponectin, lipid panel. In patients without history of CMD, an oral glucose tolerance test was performed.Results. Compared with patients without CMD, subjects with T2D had significantly higher values of BMI, waist circumference, as well as the body fat percentage, area and volume of visceral adipose tissue estimated by computed tomography. Analysis of lipid profile, C-reactive protein and adiponectin levels did not reveal significant differences between the groups. VAI also did not significantly differ in both groups. VAI had the most correlations with clinical and metabolic parameters in both patients with T2D and without CMD. Other methods for assessing obesity were less correlated with laboratory parameters in both groups. Only VAI significantly correlated with adiponectin in both groups.Conclusion. The obtained correlations between VAI and clinical and metabolic parameters confirm the practicability of using it to determine adipose tissue dysfunction in patients with/without CMD. The effect of increased VAI on the cardiovascular risk in high-risk patients requires further study.

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Section: Discussionunclassified

Visceral adiposity index in patients with coronary artery disease, obesity and type 2 diabetes

Хорлампенко

Каретникова

Кочергина

et al. 2020

Cardiovasc Ther Prev

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“…Известно, что эпикардиальная жировая ткань (ЭЖТ) является активным эндокринным органом, секретирующим ряд биологически активных веществ, которые по мере увеличения объёма жировой ткани оказывают влияние на ремоделирование и функциональное изменение сердца, приводя к фиброзу, гипертрофии, диастолической СН, что также вносит свой вклад в течение заболевания у пациентов с ППС [72,73]. Так, по результатам исследования S. Guler и соавт.…”

Section: кардиоваскулярные факторы риска у пациентов с приобретёнными...unclassified

“…Существующие данные о влиянии висцеральной жировой ткани на клапанный аппарат по большей части экспериментальные, поэтому требуется проведение дальнейших исследований по анализу вклада различных составляющих ожирения в современный портрет пациента с ППС [5,72].…”

Section: кардиоваскулярные факторы риска у пациентов с приобретёнными...unclassified

Phenotype of a modern patient with valvular heart diseases: literature review

Dren',

Lyapina,

Pecherina

et al. 2023

CardioSomatics

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In modern conditions, valvular heart diseases (VHD) are one of the most common pathologies among cardiovascular diseases with a dynamic change in the phenotype of patients. An increase in the prevalence of VHD is currently observed due to the active implementation of diagnostic methods in cardiology. Geographical differences in the genesis of the development of valvular heart defects are noted, and the portrait of patients also changes as a result of aging and the addition of comorbid pathology. The purpose of the literature review was to present current trends in changing phenotype of patients with VHD, to study current data on the epidemiology of valve pathology, the contribution of various cardiovascular risk factors and comorbidity of patients on the course of the disease. Current data on the number of surgical interventions performed for VHD based on Russian, European, American, Australian and other studies, data on patient survival and mortality, as well as differences in these indicators in age groups of different countries are presented. The review will be useful for doctors to understand the modern portrait of a patient with VHD, trends in cardiovascular risk factors that influence the course of the disease and prognosis in patients with VHD.

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“…There has been research into the expression of adiponectin genes in patients with various types of cardiovascular pathologies [117,118]. One research group studied the mRNA expression of adiponectin in adipose tissue samples from 11 males after coronary artery bypass grafting and 10 males with a replaced heart valve.…”

Section: Molecular and Genetic Studiesmentioning

confidence: 99%

The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review

et al. 2020

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Adipose tissue is considered one of the endocrine organs in the body because of its ability to synthesize and release a large number of hormones, cytokines, and growth and vasoactive factors that influence a variety of physiological and pathophysiological processes, such as vascular tone, inflammation, vascular smooth muscle cell migration, endothelial function, and vascular redox state. Moreover, genetic factors substantially contribute to the risk of obesity. Research into the biochemical effects of molecules secreted by visceral adipocytes as well as their molecular genetic characteristics is actively conducted around the world mostly in relation to pathologies of the cardiovascular system, metabolic syndrome, and diabetes mellitus. Adipokines could be developed into biomarkers for diagnosis, prognosis, and therapeutic targets in different diseases. This review describes the relevance of secretory activity molecules of visceral adipocytes in cardiovascular disease associated abdominal obesity.

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Genetic Profile and Secretome of Adipocytes From Visceral and Subcutaneous Adipose Tissue in Patients With Cardiovascular Diseases

Cited by 8 publications

References 35 publications

Visceral adiposity index in patients with coronary artery disease, obesity and type 2 diabetes

Visceral adiposity index in patients with coronary artery disease, obesity and type 2 diabetes

Phenotype of a modern patient with valvular heart diseases: literature review

The Role of Secretory Activity Molecules of Visceral Adipocytes in Abdominal Obesity in the Development of Cardiovascular Disease: A Review

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