2012
DOI: 10.1136/annrheumdis-2011-200627
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Genetic predisposition of the severity of joint destruction in rheumatoid arthritis: a population-based study

Abstract: The severity of joint destruction in RA is influenced by genetic factors.

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Cited by 64 publications
(45 citation statements)
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“…Known risk factors mainly relate to inflammation and autoantibodies and are estimated to explain 32% of the variance in joint destruction 1. Recently, the heritability of the rate of joint destruction was estimated to be 58% 2. Identifying individual genetic risk factors may increase our understanding of the mechanisms underlying differences in severity of joint destruction.…”
Section: Introductionmentioning
confidence: 99%
“…Known risk factors mainly relate to inflammation and autoantibodies and are estimated to explain 32% of the variance in joint destruction 1. Recently, the heritability of the rate of joint destruction was estimated to be 58% 2. Identifying individual genetic risk factors may increase our understanding of the mechanisms underlying differences in severity of joint destruction.…”
Section: Introductionmentioning
confidence: 99%
“…Genetic variants are estimated to contribute to 58% of the total variance in RA joint destruction, with clinical and serological risk factors explaining only about one-third of the total phenotypic variation 6. Most risk alleles for RA joint destruction have been identified in ACPA-positive patients or in pooled ACPA-negative and ACPA-positive patients, but we lack information about the genetic contribution to ACPA-negative RA severity 7–9.…”
Section: Introductionmentioning
confidence: 99%
“…Genetic factors are estimated to explain half of this variance1; environmental factors likely play a role as well. No clear environmental risk factors for joint damage progression have been identified.…”
Section: Introductionmentioning
confidence: 99%