Genetic polymorphisms of non-coding RNAs associated with increased head and neck cancer susceptibility: a systematic review and meta-analysis

Abstract

Genetic polymorphisms, including single nucleotide polymorphisms (SNP) and nucleotide repeat expansions, can occur in regions that transcribe non-coding RNAs (ncRNA), such as, but not limited to, micro RNA and long non-coding RNA. An association between genetic polymorphisms of ncRNA and increasing head and neck cancer (HNC) risk has been identified by several studies. Therefore, the aim of this systematic review is to consolidate existing findings to clarify this association. Four electronic databases, such as MEDLINE, EMBASE, Chinese BioMedical Literature Database, and China National Knowledge Infrastructure, were utilised. Inclusion of studies and data extraction were accomplished in duplicate. A total of 42 eligible studies were included, involving 28,527 cases and 37,151 controls. Meta-analysis, sensitivity analysis and publication bias detection were performed. Among the eligible studies, 102 SNPs were investigated, and 21 of them were considered eligible for meta-analysis. Our analysis revealed that HOTAIR rs920778, uc003opf.1 rs11752942, and miR-196a2 rs11614913 were related to HNC susceptibility, while let-7 rs10877887, miR-124-1rs531564, and miR-608 rs4919510 were considered as protective factors. In conclusion, our results showed the extreme importance of an up-to-date comprehensive meta-analysis encompassing the most recent findings to obtain a relevant and reliable framework to understand the relationship between ncRNA SNPs and HNC susceptibility.

Absence of Salivary lncRNA-XIST Indicates High Susceptibility to Oral Cancer

“…Numerous studies have provided evidence regarding aberrant expression of tumorigenic genes in OSCC and cancer diagnostic and prognostic biomarkers. Single nucleotide polymorphisms in the coding and noncoding RNA genes have been analyzed most commonly [27][28][29]. This study is the first, to our knowledge, to investigate the role of X-linked genes in saliva in OSCC.…”

Impact of HOTAIR Gene Polymorphism and Environmental Risk on Oral Cancer

“…Four common polymorphisms from the HOTAIR gene examined in this investigation were selected on the basis of their potential involvement in the susceptibility to the development of various cancer types (Du et al 2015; Sharma Saha et al 2016; Pan et al 2017). Genomic DNA was extracted from whole blood with QIAamp DNA Blood Mini Kits (Qiagen) as previously described in detail (Hua et al 2017).…”

“…Despite being noncoding, transcripts of HOTAIR can regulate chromatin dynamics and cancer-related gene expression by acting as a modular scaffold to interact with polycomb repressive complex 2 (Rinn et al 2007) and lysine-specific demethylase 1 (Tsai et al 2010), competing with breast cancer type 1 susceptibility protein to bind to a histone methyltransferase (enhancer of zeste homolog 2; Wang et al 2013), and serving as a competing endogenous RNA for miR-331-3p, miR-124, and miR-193a (Xing et al 2015). In recent years, an explosion of reports has demonstrated the associations of HOTAIR gene polymorphisms with the susceptibility to many cancer types, such as esophageal, breast, ovarian, cervical, gastric, colorectal, and head and neck cancer (Zhang et al 2014; Bayram et al 2015; Xue et al 2015; Pan et al 2016; Pan et al 2017). However, the joint effects of HOTAIR gene polymorphisms and habitual exposure of cancer-causing substances on the risk of oral cancer remain unexplored.…”

A Looking-Glass of Non-Coding RNAs in Oral Cancer

“…They can function as scaffolds for higher-order complexes, signaling molecules via exosomes, and vehicles for increased genetic diversity [ 105 ]. The tissue specificity of lncRNAs might enable them to be valuable biomarkers and therapeutic agents [ 41 ], based on their expression levels or related with the presence or absence of certain mutation [ 106 ].…”

“…The important role of Hotair as a biomarker is sustained by a recent meta-analysis study [ 121 ]. Hotair overexpression was related with unfavorable prognostic, advanced tumor stage and the presence of metastases [ 121 ] In the case of Hotair , certain genetic alterations (rs920778, uc003opf.1, and rs11752942) were related with head and neck cancer susceptibility [ 106 ].…”