A Looking-Glass of Non-Coding RNAs in Oral Cancer

Irimie, Alexandra Iulia; Braicu, Cornelia; Sonea, Laura; Zimța, Alina-Andreea; Cojocneanu, Roxana; Tonchev, Konstantin; Mehterov, Nikolay; Diudea, Diana; Buduru, Smaranda

doi:10.3390/ijms18122620

Cited by 53 publications

(39 citation statements)

References 163 publications

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“…Considering the complexity of the HNSCC molecular mechanism, most studies have focused on coding and noncoding genes. MicroRNAs (miRNAs) are noncoding transcripts, 18-22 nucleotide long RNAs, being vital posttranscriptional regulators of gene expression [7]; at the cellular level they might act as oncogenes or tumor suppressor genes affecting cell proliferation, invasion, migration, self-renewal capacity, resistance to therapy, and autophagy [8,9].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

Irimie-Aghiorghiesei

Pop-Bica

Pintea

et al. 2019

JCM

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Head and neck squamous cell carcinoma (HNSCC) is a group of malignancies with serious impact on patient quality of life due to a reduced rate of response to chemotherapy or radiation therapy. MiR-21 has been identified as one of the most common proto-oncogenes. It is hypothesized that upregulated miR-21 could serve as a potential biomarker for human cancer diagnosis. Considering the target genes identified for miR-21 in HNSCC, this transcript is an important player in several cellular processes that control carcinogenesis. The abnormal expression of miR-21 in this group of pathologies has been assessed in several publications, but given the heterogeneity of the published results, a meta-analysis and proper bioinformatics analysis of expression databases are needed to correctly establish the prognostic potential of this molecule. The present meta-analysis comprises the published survival data on HNSCC patients, reported as HR and 95% CI, in association with the expression levels of miR-21. Our investigation revealed that miR-21 could be used successfully as a prognostic biomarker in HNSCC patients, confirming its oncogenic potential. Specifically, the upregulation of miR-21 in these patients predicts a worse outcome in terms of survival rate.

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Section: Introductionmentioning

confidence: 99%

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

Irimie-Aghiorghiesei

Pop-Bica

Pintea

et al. 2019

JCM

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“…Classic tumor markers such as serum squamous cell carcinoma antigen, carbohydrate antigen 19-9, and carcinoembryonic antigen are used in the management of patients with OSCC. However, due to insufficient diagnostic sensitivity and specificity, they have limited utility in the early detection of this disease [3]. Therefore, new biomarkers with high sensitivity and specificity should be explored for the early detection of OSCC.…”

Section: Introductionmentioning

confidence: 99%

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

Zhao

Wang

Ouyang

et al. 2018

Cell Physiol Biochem

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Background/Aims: Recent studies have demonstrated that circular RNAs (circRNAs) can serve as potential molecular markers for disease diagnosis. However, little is known about their diagnostic potential for oral squamous cell carcinoma (OSCC). This study aimed to determine the expression of circRNAs in the saliva of OSCC patients to identify novel biomarkers for OSCC screening. Methods: Microarray screening of circRNA was performed to identify differentially expressed circRNAs in saliva from 3 OSCC patients compared with 3 healthy controls. Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the results, and the association between these confirmed salivary circRNAs and clinicopathological features was analyzed using the chi-squared test. A receiver operating characteristic (ROC) curve was constructed to evaluate the diagnostic value of the circRNAs identified. Preoperative expression and postoperative expression (1 month after the surgery) of hsa_circ_0001874 and hsa_circ_0001971 was also determined. Results: Our results indicated 12 upregulated and 20 downregulated circRNAs in the saliva from the OSCC patients compared with that from the healthy controls. Among the differentially expressed circRNAs, hsa_circ_0001874, hsa_circ_0001971, and hsa_circ_0008068 were upregulated and hsa_circ_0000140, hsa_circ_0002632, and hsa_circ_0008792 were downregulated in the OSCC group versus the healthy group. Clinical data indicated that salivary hsa_circ_0001874 was correlated with TNM stage (P=0.006) and tumor grade (P=0.023) and that hsa_circ_0001971 was correlated with TNM stage (P=0.019). The combination of hsa_circ_0001874 and hsa_circ_0001971 showed an area under the ROC curve of 0.922 (95% confidence interval, 0.883-0.961; P< 0.001). The risk score based on the combination of hsa_circ_0001874 and hsa_circ_0001971 also discriminated patients with OSCC from patients with oral leukoplakia (P< 0.001). Moreover, the expression levels of salivary hsa_circ_0001874 and hsa_circ_0001971 were clearly decreased in the postoperative samples compared with preoperative samples (P< 0.001). Conclusions: This is the first study to demonstrate the potential of salivary hsa_circ_0001874 and hsa_circ_0001971 as biomarkers for the diagnosis of OSCC.

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“…Oral cancer is a general term for malignant tumours that occur in the mouth, ninety percent of which are oral squamous cell carcinomas (OSCCs) [1]. Globally, a large number of new cases of OSCC are diagnosed every year [2]. Oesophageal cancer, mainly oesophageal squamous cell carcinoma (ESCC), is not only the eighth most common cancer but also the sixth most common cause of death from cancer throughout the world.…”

Section: Introductionmentioning

confidence: 99%

The Regulatory Functions of Circular RNAs in Digestive System Cancers

Yuan

Yuán

et al. 2020

Cancers

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Circular ribonucleic acids (circRNAs), which are a type of covalently closed circular RNA, are receiving increasing attention. An increasing amount of evidence suggests that circRNAs are involved in the biogenesis and development of multiple diseases such as digestive system cancers. Dysregulated circRNAs have been found to act as oncogenes or tumour suppressors in digestive system cancers. Moreover, circRNAs are related to ageing and a wide variety of processes in tumour cells, such as cell apoptosis, invasion, migration, and proliferation. Moreover, circRNAs can perform a remarkable multitude of biological functions, such as regulating splicing or transcription, binding RNA-binding proteins to enable function, acting as microRNA (miRNA) sponges, and undergoing translated into proteins. However, in digestive system cancers, circRNAs function mainly as miRNA sponges. Herein, we summarise the latest research progress on biological functions of circRNAs in digestive system cancers. This review serves as a synopsis of potential therapeutic targets and biological markers for digestive system cancer.

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A Looking-Glass of Non-Coding RNAs in Oral Cancer

Cited by 53 publications

References 163 publications

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

Prognostic Value of MiR-21: An Updated Meta-Analysis in Head and Neck Squamous Cell Carcinoma (HNSCC)

Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma

The Regulatory Functions of Circular RNAs in Digestive System Cancers

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