Genetic polymorphisms of cytochrome P450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan

Wu, Ming–Shiang; Chen, Chien-Jen; Lin∥, Ming–Tsan; Wang, Hsiu-Po; Shun, Chia‐Tung; Sheu, Jin‐Chuan; Lin, Jaw–Town

doi:10.1007/s00384-001-0383-2

Cited by 63 publications

(39 citation statements)

References 26 publications

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“…21 Other studies, some of which were hospitalbased and mostly carried out in Asian populations, have shown that GST null genotypes did not contribute to an increased GC risk. 24,[27][28][29] Our analyses did not show any evidence of increased GC risk among subjects with GSTM1 null genotype, while a borderline significant association between the GSTT1*0/0 and increased GC risk emerged in uni-and multivariate analyses adjusted for possible confounders, as reported by previous studies. 18,19 The risk associated with the GSTT1 null genotype tended to vary also with age at diagnosis, with a higher risk at younger ages.…”

Section: Discussionsupporting

confidence: 74%

“…On the other hand several studies, mostly carried out in Asian populations (for which a higher prevalence of the GSTT1 null genotype has been reported), did not find any association between the GST null genotypes and increased GC risk. [24][25][26][27][28][29] Recently, a strong significant association between the GSTT1 null genotype and increased risk of another gastric neoplasia (marginal zone lymphoma) was observed in a case-control study carried out in England. 30 The interaction between GSTM1 and GSTT1 null genotypes has only been explored in 2 studies, with no evidence of departure from a multiplicative model, possibly because of the small size (91 and 136 GC cases, respectively).…”

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confidence: 99%

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GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

Palli

Saieva

Gemma

et al. 2005

Intl Journal of Cancer

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Glutathione S-Transferases (GSTs) are a family of phase II enzymes involved in the detoxification of potential carcinogens and provided of a strong antioxidant function by neutralizing electrophiles and free radicals. The GSTM1 and GSTT1 isoenzymes exhibit deletion polymorphisms, resulting in a lack of activity, and the null genotypes have been associated with increased cancer risk at several sites, including the stomach, although with contrasting results. We carried out a case-control study to evaluate whether these polymorphisms modulate the risk of developing gastric cancer (GC). Genotypes for GSTM1 and GSTT1 were obtained from a series of 175 histologically confirmed GC patients and a large series of 546 healthy controls randomly sampled from the general population of Tuscany, an area at high GC risk. No difference in the frequency of GSTM1 null genotype was observed between cases and controls, whereas the GSTT1 null genotype was more frequent among cases (p ¼ 0.04). Multivariate single-gene analyses adjusted for possible confounders showed that the GSTT1 null genotype, but not the GSTM1 null genotype, was associated with an increased GC risk. Combined-genotype analyses showed a significantly increased GC risk only for the double null (GSTM1-GSTT1) genotype (OR ¼ 2.27; 95% CI: 1.14-4.53). A statistically significant positive interaction between the 2 null genotypes was observed (p ¼ 0.02). Our findings suggest that only subjects lacking both GSTM1 and GSTT1 activity are at increased GC risk. This study provides further support to the hypothesis that the risk of developing GC is influenced by inter-individual variation in both carcinogen detoxification and antioxidant capacity. ' 2005 Wiley-Liss, Inc.

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Section: Discussionsupporting

confidence: 74%

mentioning

confidence: 99%

GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

Palli

Saieva

Gemma

et al. 2005

Intl Journal of Cancer

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“…However, Nishimoto et al, (2000) suggests that the CYP2E1 RsaI variant genotype is associated with a reduced risk of upper gastrointestinal tract cancers. Wu et al, (2002) found an association of gastric cancer with CYP2E1 RsaI, but not with CYP2E1 DraI. Earlier, in a meta-analysis, Boccia et al, (2007) concluded that CYP2E1-PstI/RsaI polymorphism may be a risk factor for gastric cancer in Asian populations.…”

Section: Discussionmentioning

confidence: 98%

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

Malakar

Devi²,

Phukan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…Por otro lado, para el genotipo de deleción de GSTT1 no se encontró asociación con cáncer gástrico (17,4% en los casos y 14,6% en los controles). Los estudios que han investigado también la relación de GSTT1 y cáncer gástrico han arrojado igualmente resultados conflictivos (13,22,29,(33)(34)(35)(36). Esto puede deberse al efecto combinado de la variación en la frecuencia de estos polimorfismos entre diferentes grupos étnicos (37) y la exposición a distintos factores ambientales sobre los cuales actúa la GST.…”

Section: Discussionunclassified

Susceptibilidad genética y riesgo de cáncer gástrico en una población del Cauca.

Torres¹,

Acosta²,

Sicard³

et al. 2004

biomedica

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El cáncer gástrico es la principal causa de mortalidad por cáncer en Colombia. El riesgo de desarrollar cáncer gástrico se ha asociado con factores ambientales y con la infección por Helicobacter pylori. Las enzimas glutatión-S-transferasas están involucradas en la desintoxicación de varios carcinógenos ambientales. Las deleciones homocigóticas de glutatión-S-transferasa M1 (GSTM1-0) y glutatión-S-transferasa T1 (GSTT1-0) se han asociado con algunos tipos de cáncer. Los niveles del factor de necrosis tumoral (FNT α) están aumentados en pacientes infectados por H. pylori. Una transición G/A en la posición -308 del promotor del FNT-α se ha visto relacionada en algunos estudios con un incremento en la expresión del gen, y está asociada con la susceptibilidad a cáncer gástrico. Se investigó la asociación de estos polimorfismos con cáncer gástrico y la interacción con otros factores de riesgo (estilo de vida). Se obtuvieron muestras de sangre de 46 pacientes con cáncer gástrico y 96 controles. Se empleó el modelo de regresión logística para obtener la razón de posibilidades (OR) y sus intervalos de confianza del 95% y, así, establecer la asociación entre los polimorfismos enzimáticos y el cáncer gástrico, y entre otros factores independientes y esta enfermedad. Las frecuencias de los polimorfismos de deleción en pacientes y controles fueron: para la GSTM1, 65,2% y 37,5%, y para la GSTT1, 17,4% y 14,6%, respectivamente. La frecuencia del polimorfismo G/A del FNT α en las personas infectadas con H. pylori fue de 18% en la población con cáncer gástrico y de 7% en el grupo control. Nuestros resultados sugieren que el polimorfismo de deleción de GSTM1 puede estar asociado con un riesgo aumentado de cáncer gástrico (OR 5,5; IC95%, 1,7-17,2). Igualmente, nuestros datos muestran que otros factores de riesgo como la infección por H. pylori y el consumo de cigarrillo y alcohol están asociados con este tipo de cáncer (OR 5,58; IC95% 1,81-17,19; OR 6,70; IC95%, 2,20-20,30 y OR 3,27; IC95% 1,14-9,4, respectivamente).Palabras clave: cáncer gástrico, glutatión-S-transferasas, polimorfismos, Colombia. Genetic susceptibility and risk of gastric cancer in a human population of Cauca, ColombiaGastric cancer (GC) is the main cause of mortality by cancer in Colombia. Glutathione Stransferase (GST) enzymes are involved in the detoxification of many environmental carcinogens. The homozygous deletions of glutathione S-transferase M1 (GSTM1-0) and glutathione Stransferase T1 (GSTT1-0) have been associated with several types of cancer. The risk to develop GC has been associated with environmental factors and Helicobacter pylori infection. The tumor necrosis factor (TNF-α) and its levels are increased in patients infected with H. pylori. A G/ A transition in the position -308 of the promoter of the TNF-α has been related in several studies to an increased expression of the gene and is associated with susceptibility to GC. The association of these polymorphisms with GC and the interaction with other risk factors (life style) were investigated. ...

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Genetic polymorphisms of cytochrome P450 2E1, glutathione S-transferase M1 and T1, and susceptibility to gastric carcinoma in Taiwan

Abstract: Our findings suggest that the CYP2E1 genotype is a determinant of GC risk in Taiwan.

Cited by 63 publications

References 26 publications

GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

GSTT1 and GSTM1 gene polymorphisms and gastric cancer in a high‐risk italian population

CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India

Susceptibilidad genética y riesgo de cáncer gástrico en una población del Cauca.

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