Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of North Central India: An association study with pulmonary tuberculosis

Mishra, G. C.; Poojary, Satish S.; Raj, Prithvi; Tiwari, Pramod Kumar

doi:10.1016/j.meegid.2012.03.018

Cited by 34 publications

(32 citation statements)

References 24 publications

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“…A similar result has been reported in Ghanaian and Moroccan population where G allele and GG genotype of −2518A/G polymorphism are associated with protection against TB (Thye et al ., ; Arji et al ., ). However, no association was found in various groups of population (Jamieson et al ., ; Chu et al ., ; Naderi et al ., ; Mishra et al ., ; Velez Edwards et al ., ). Page et al .…”

Section: Discussionmentioning

confidence: 99%

CCL2, CCL3 and CCL4 gene polymorphisms in pulmonary tuberculosis patients of South India

2013

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Polymorphisms in chemokine genes are important to determine the host-pathogen interactions which influence the chemokine levels. This study was carried out to find whether various CC chemokine gene polymorphisms, located in the promoter, exon-2 and intron-1 regions are associated with susceptibility or resistance to pulmonary tuberculosis (PTB) in south Indian population. The polymorphisms in various CC chemokine genes, MCP-1 (CCL2) [-2518A/G, 903C/T], MIP-1α (CCL3) [-2021C/T, +740A/G] and MIP-1β (CCL4) [-5725A/C] were studied in 295 healthy controls (HCs) and 303 patients with PTB using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). The allele and genotype frequencies of CCL2, CCL3 and CCL4 were not different between HCs and patients with PTB. However, a significantly decreased frequency of CCL2 -2518GG genotype was observed in male patients with PTB [P value = 0.015, P corrected (Bonferroni correction) Pc = 0.045, odds ratio (OR) 0.43 95% CI (0.21-0.86)], and a significantly increased frequency of the same genotype was observed among female patients with PTB [P value = 0.049, Pc = 0.147, OR 2.28 95% CI (1.00-5.27)]. The results suggest that -2518GG genotype may be associated with protection in males and susceptibility to PTB in females. Moreover, we also observed differences in the haplotype frequencies of these chemokine genes between HCs and patients with PTB. However, these polymorphisms are not associated with disease independently, probably in combination with other genes, they may be associated with susceptibility or resistance to TB in south Indian population.

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Section: Discussionmentioning

confidence: 99%

CCL2, CCL3 and CCL4 gene polymorphisms in pulmonary tuberculosis patients of South India

2013

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“…The gene encoding MCP-1 is located in the 17q11.2-q12 chromosomal region; single-nucleotide polymorphisms such as -2518A/G (rs1024611) and -362G/C (rs2857656) have been identified. These polymorphisms may influence MCP-1 secretion, impacting TB susceptibility (Mishra et al, 2012).…”

Section: Tuberculosis (Tb) Is An Infectious Disease Caused By the Bacmentioning

confidence: 99%

“…The African group included 5 studies [Buijtels et al, 2008;Möller et al, 2009;Thye et al, 2009;Velez Edwards et al, 2012 (2 case-control (Ben-Selma et al, 2011;Hussain et al, 2011;Arji et al, 2012). The Asian group included 10 studies (Flores-Villanueva et al, 2005;Chu et al, 2007;Alagarasu et al, 2009;Xu et al, 2009;Yang et al, 2009;Feng et al, 2011;Naderi et al, 2011;Mishra et al, 2012;Zhang et al, 2012;Singh et al, 2014). All studies analyzed the association between MCP-1 -2518A/G polymorphisms and human TB susceptibility.…”

Section: Characteristics Of Studies Includedmentioning

confidence: 99%

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

Tian¹,

Li²,

Li³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Numerous studies have been conducted to investigate the association between 2518A/G polymorphisms in the monocyte chemoattractant protein-1 (MCP-1) gene and the risk of tuberculosis (TB). However, the results have been inconsistent and inconclusive. In this study, we performed a meta-analysis to evaluate the association between the MCP-1 -2518A/G polymorphism and TB. The National Center for Biotechnology Information Global Cross Database and Google Scholar database were searched for relative studies. A total of 22 case-control studies that included 7332 cases and 8004 controls for the -2518A/G single-nucleotide polymorphism were identified. The results revealed an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility under a recessive model (GG vs GA+AA), dominant model (GG+GA vs AA), and homozygote comparison (GG vs AA) model for the entire database. For the dominant model, the overall odds ratio was 1.34 (95% confidence interval, 1.10-1.64, P = 0.004). For the recessive model, the overall odds ratio was 1.46 (95% confidence interval, 1.15-1.86, P = 0.002). For the homozygote comparison, the overall odds ratio was 1.67 (95% confidence interval, 1.20-2.32, P = 0.002). In the subgroup analysis by ethnicity, significantly elevated risks were found in Asians and Americans, but not in Africans and Europeans. We also used the Begg and Egger tests to examine publication bias, and no major publication bias was detected. Our results indicate that there is an association between the MCP-1 -2518A/G polymorphism and human TB susceptibility.

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“…Based upon the understanding regarding the functional significance of this genetic variant, it has been considered as a potential susceptibility factor for TB. Till now, a relatively few number of studies have been carried out in different populations but their results are remaining inconsistent and conflicting rather than conclusive [16]–[21]. Inconsistencies in their results can be attributed in terms of sample size and ethnic diversity, and individual studies may have low power to detect overall effect.…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of the Association between the CC Chemokine Ligand 5 (CCL5) -403 G>A Gene Polymorphism and Tuberculosis Susceptibility

et al. 2013

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AimMany case-control studies have been performed in the recent past to investigate the association between CCL5 -403 G>A (rs2107538) gene polymorphism and tuberculosis (TB) susceptibility in various ethnic groups. However, these studies have produced inconsistent and contradictory results. In the present study, meta-analysis was performed to assess the association between CCL5 -403 G>A polymorphism and TB risk.MethodologyQuantitative synthesis was done for the published studies based upon association between CCL5 -403 G>A polymorphism and TB risk from PubMed (Medline), EMBASE web search. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for allele contrast, homozygous, heterozygous, dominant and recessive genetic models.ResultsA total of six studies comprising 1638 confirmed TB cases and 1519 healthy controls were included in this meta-analysis. Variant A allele (A vs. G: p = 0.035; OR = 1.301, 95% CI = 1.019 to 1.662) and variant homozygous (AA vs. GG; p = 0.001; OR = 1.520, 95% CI = 1.202 to 1.923) carriers were significantly associated with TB susceptibility. Similarly, recessive model (AA vs. GG+GA: p = 0.016; OR = 1.791, 95% CI = 1.117 to 2.873) also indicated increased TB risk. Whereas, heterozygous (GA vs. GG: p = 0.837; OR = 1.028, 95% CI = 0.791 to 1.335) and dominant (AA+GA vs. GG: p = 0.222; OR = 1.188, 95% CI = 0.901 to 1.567) models failed to show increased risk of developing TB.ConclusionsThis meta-analysis suggests that there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB. However, larger well-designed epidemiological studies with stratified case control and biological characterization may be helpful to validate this association.

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Genetic polymorphisms of CCL2, CCL5, CCR2 and CCR5 genes in Sahariya tribe of North Central India: An association study with pulmonary tuberculosis

Cited by 34 publications

References 24 publications

CCL2, CCL3 and CCL4 gene polymorphisms in pulmonary tuberculosis patients of South India

CCL2, CCL3 and CCL4 gene polymorphisms in pulmonary tuberculosis patients of South India

Systematic meta-analysis of the association between monocyte chemoattractant protein-1 -2518A/G polymorphism and risk of tuberculosis

A Meta-Analysis of the Association between the CC Chemokine Ligand 5 (CCL5) -403 G>A Gene Polymorphism and Tuberculosis Susceptibility

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