A Meta-Analysis of the Association between the CC Chemokine Ligand 5 (CCL5) -403 G&gt;A Gene Polymorphism and Tuberculosis Susceptibility

Areeshi, Mohammed Y.; Mandal, Raju K.; Panda, Aditya K.; Haque, Shafiul

doi:10.1371/journal.pone.0072139

Cited by 8 publications

(6 citation statements)

References 25 publications

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“…Numerous studies have investigated the role of the CCL5 rs2107538 polymorphism in various diseases. Areeshi et al (29) performed a meta-analysis to evaluate the association between the polymorphism and tuberculosis susceptibility, and identified a significant link with increased risk of tuberculosis. In the study by Sáenz-López et al (11), the G/A + A/A genotype of CCL5 rs2107538 was reported to be significantly associated with an increased risk of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia

Pang

Gong

et al. 2019

Oncol Rep

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Benign prostatic hyperplasia (BPH) is a common chronic disease in older males. The pathogenesis of BPH remains elusive but may be associated with chronic inflammation. Chemokines and chemokine receptors have been implicated as critical mediators in the immune response and inflammatory processes. In the present study, the aim was to evaluate the association of three polymorphisms in chemokine genes, namely C-C motif chemokine ligand (CCL)2 rs1024611, CC chemokine receptor 2 (CCR2) rs1799864 and CCL5 rs2107538, with BPH risk. These polymorphisms were genotyped in 109 patients with BPH and 160 control subjects, using the polymerase chain reaction and multiple ligase detection reaction method. The CCL5 rs2107538 polymorphism was identified to be associated with a significantly lower risk of BPH [A/G vs. G/G: Odds ratio (OR)=0.37, 95% confidence interval (CI)=0.17-0.78; A/A + A/G vs. G/G: OR= 0.39, 95% CI= 0.19-0.79; A vs. G: OR= 0.58, 95% CI=0.35-0.96). However, this polymorphism was also associated with the development of larger prostate volumes in patients with BPH (A/G vs. G/G: OR=3.02, 95% CI=1.28-7.11; AA + AG vs. GG: OR=2.83, 95% CI=1.28-6.26; A vs. G: OR=1.94, 95% CI=1.08-3.49). The CCR2 rs1799864 polymorphism was associated with lower International Prostate Symptom Score values (A/A + A/G vs. G/G: OR=0.39, 95% CI=0.17-0.91; A vs. G: OR=0.43, 95% CI=0.20-0.90) and low Qmax (A/G vs. G/G: OR=0.38, 95% CI=0.16-0.92; AA + AG vs. GG: OR=0.39, 95% CI=0.17-0.91) in the patients. No association was observed between the CCL2 rs1024611 polymorphism and BPH. These results suggest that the CCR2 and CCL5 genes may contribute to the occurrence and progression of BPH.

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Section: Discussionmentioning

confidence: 99%

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia

Pang

Gong

et al. 2019

Oncol Rep

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“…Sadek et al 31 reported that CCL5 levels on bronchoalveolar lavage fluid in patients with active PTB increased nearly 8 times higher than that in the control group. According to a previous study, 32 there is a significant association between the CCL5 -403 G>A polymorphism and increased risk of TB. Another study 33 showed that genetic polymorphism -28C>G in CCL5 is not associated with increased TB risk.…”

Section: Discussionmentioning

confidence: 86%

The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility

Lü

Wang

Gao

et al. 2015

SMJ

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Objectives:To assess the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB) risk.Methods:PubMed, Web of Science, and WanFang were searched up to April 2015 for eligible studies on CCL5 -28C>G polymorphism. Data was extracted, and pooled odd ratios (ORs) as well as 95% confidence intervals (95% CI) were calculated.Results:Eight case-control studies were extracted from 8 articles on the polymorphism involving 1852 TB cases and 2068 controls. The results of meta-analysis showed that significant reduced risks were found for the polymorphism with the risk of TB in Asians and Arabs as follows: OR=0.12, 95% CI=0.06-0.26, p=0.000 for mutant homozygous (GG) versus wild-type homozygous (CC) for Asian descent, OR=0.14, 95% CI=0.07-0.28, p=0.000 for GG versus CC in the Arab descent.Conclusion:Our findings demonstrated that CCL5 gene -28C>G polymorphism might be a protective factor for the development of TB.

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“…RANTES is a potent chemoattractant factor for monocytes and T cells and is associated with the function of cytotoxic T cells, which are important in the control of various intracellular pathogens (33). RANTES polymorphisms are associated with an increased risk of TB (34)(35)(36). In the current study, we found that recombinant RANTES protein or plasma RANTES did not signi cantly alter IL-1β production by macrophages (Fig.…”

Section: Discussionmentioning

confidence: 99%

Impaired expression of the TWIK2 K+ efflux channel leads to reduced IL-1 family cytokine production in patients with nontuberculous mycobacterial lung disease

Jung

Dean

Wadle

et al. 2022

Preprint

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Background: Nontuberculous mycobacteria (NTM) causes disseminated disease in patients with immunodeficiency and pulmonary disease in individuals without obvious immunodeficiency. There is no clear information on how NTM pulmonary disease (NTMPD) develops in immunocompetent hosts. This profile study was initiated to gain insight into the immunological factors that predispose persons to pulmonary NTM infections.Methods: Blood samples were obtained from 15 pairs of NTMPD patients and age-matched healthy household contacts. Peripheral blood mononuclear cells (PBMCs) were stimulated with the heat-killed M. avium complex (MAC). A total of 34 cytokines and chemokines were evaluated in PBMCs culture supernatants and plasma using multiplex immunoassays. The mRNA expression of TLR2, P2X7R, TWIK2, THIK2 and TREK1 was measured by quantitative real-time PCR. In mechanistic studies, blood samples were obtained from healthy volunteers who had not been diagnosed or treated for NTM.Results: Interleukin (IL)-1β, IL-18, IL-1α and IL-10 production were significantly reduced in response to MAC in PBMCs of NTMPD patients compared with PBMCs of their healthy household contacts. RANTES was the only chemokine significantly elevated in the plasma of NTMPD patients compared with plasma of their healthy household contacts. TLR2 and TWIK2 expression were impaired in response to MAC in PBMCs of NTMPD patients compared with PBMCs of their healthy household contacts. RANTES had no effect on IL-1β production by macrophages infected with MAC. A TLR2 inhibitor decreased IL-1β, IL-18, IL-1α and IL-10 production by MAC-stimulated PBMCs and monocytes. A TWIK2 inhibitor decreased the production of IL-1β, IL-18, and IL-1α, but not IL-10, by MAC-stimulated PBMCs and monocytes.Conclusions: These findings suggest that impaired TWIK2 results in decreased production of IL-1 family cytokines (IL-1β, IL-18, and IL-1α) in response to MAC, consequentially may increase susceptibility to NTM pulmonary infection.

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A Meta-Analysis of the Association between the CC Chemokine Ligand 5 (CCL5) -403 G>A Gene Polymorphism and Tuberculosis Susceptibility

Cited by 8 publications

References 25 publications

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia

Association of CCL2, CCR2 and CCL5 genetic polymorphisms with the development and progression of benign prostatic hyperplasia

The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility

Impaired expression of the TWIK2 K+ efflux channel leads to reduced IL-1 family cytokine production in patients with nontuberculous mycobacterial lung disease

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