The association between the CC chemokine ligand 5 -28C&gt;G gene polymorphism and tuberculosis susceptibility

Lü, Hongfang; Wang, Jingang; Gao, Baoan; Chen, Shixiong; Xiang, Guangming; Yang, Shichao; Gong, Yuan; Guan, Li

doi:10.15537/smj.2015.12.12264

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…For example, interferon gamma ( IFNG ) and interleukin 17 ( IL17 ) polymorphisms were reported to be associated with TB risk 7,8 . Several meta-analyses suggested that cytokines such as IL10, IL12B, IL27 and CC chemokine ligand 5 (CCL5) play important roles in the progression of TB 9–12 . Indeed, genetic variants in cytokine genes could affect the recognition sites of the transcription factors, leading to altered transcriptional activity, which may then result in a change in cytokine production levels 13 .…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms of cytokine genes and tuberculosis in two independent studies

Wang

et al. 2019

Sci Rep

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Cytokine gene single nucleotide polymorphisms (SNPs) can influence cytokine levels, which may be associated with tuberculosis (TB) susceptibility. There is evidence that interleukin 1B (IL1B), tumor necrosis factor-alpha (TNF-alpha), and IL6 may be involved in the progression of TB. Using a self-validating case-control design, we selected eleven functional SNPs in IL1B , TNF and IL6 to detect their association with TB in Chinese Han and Tibetan populations. The associations between SNPs and TB were estimated by computing the odds ratios (ORs) and 95% confidence intervals (95% CI) using logistic regression analyses. We found that the IL1B rs16944 polymorphism was associated with decreased risk of TB in the two studies. The G allele at rs2069837 of IL6 was significantly more common in controls than in TB patients in the Han population. Moreover, TNF rs1799964 and rs1800630 were risk factors for susceptibility to TB, which were validated in the Chinese Tibetan population. In addition, TNF rs1799724 and rs1800629 were associated with TB, but only in the Tibetan population. In conclusion, SNPs of the IL1B and TNF gene were associated with TB susceptibility in Chinese Han and Tibetan populations. IL6 polymorphism may be considered as a protective factor for TB in the Chinese Han population, but not the Tibetan population.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms of cytokine genes and tuberculosis in two independent studies

Wang

et al. 2019

Sci Rep

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“…We read with interest the article by Lu et al 1 published in this journal. In their systematic review and meta-analysis, the authors assessed the association between chemotactic chemokine (C-C motif) ligand 5 (CCL5) -28C>G polymorphism and tuberculosis (TB).…”

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confidence: 99%

The association between the CC chemokine ligand 5-28>G and tuberculosis susceptibility

Adwan

2016

SMJ

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The Research Progress of Host Genes and Tuberculosis Susceptibility

Cai

Zhan

Guan

et al. 2019

Oxidative Medicine and Cellular Longevity

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Background/Aims. Nucleotide diversity may affect the immune regulation of tuberculosis (TB) patients, leading to the individual susceptibility to TB. In recent years, there are a lot of researches on the association of host genetic factors and TB susceptibility which has attracted increasing attention, and the in-depth study of its mechanism is gradually clear. Materials. We made a minireview on the association of many candidate genes with TB based on recent research studies systematically, such as the human leukocyte antigen (HLA) gene, the solute carrier family 11 member 1 (SLC11A1) gene system, the vitamin D receptor (VDR) gene, the mannan-binding lectin (MBL) gene, the nitric oxide synthase 2A (NOS2A) gene, the speckled 110 (SP110) gene, and the P2X7 receptor (P2X7) gene. The discovery of these candidate genes could reveal the pathogenesis of TB comprehensively and is crucial to provide scientific evidence for formulating the related measures of prevention and cure. Discussion. The host genes play important roles in the development of TB, and the host genes may become new targets for the prevention and treatment of TB. Effective regulation of host genes may help prevent or even treat TB. Conclusion. This minireview focuses on the association of host genes with the development of TB, which may supply some clues for future therapies and novel drug targets for TB.

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The association between the CC chemokine ligand 5 -28C>G gene polymorphism and tuberculosis susceptibility

Cited by 5 publications

References 30 publications

Polymorphisms of cytokine genes and tuberculosis in two independent studies

Polymorphisms of cytokine genes and tuberculosis in two independent studies

The association between the CC chemokine ligand 5-28>G and tuberculosis susceptibility

The Research Progress of Host Genes and Tuberculosis Susceptibility

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