Genetic Polymorphisms of Apolipoprotein C-Iii and Insulin in Survivors of Myocardial Infarction

Ferns, G.; Ritchie, C D; Stocks, J.; Galton, D. J.

doi:10.1016/s0140-6736(85)90350-2

Cited by 103 publications

(31 citation statements)

References 15 publications

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“…A summary of their data is presented in Table 3 together with our data. Both the $2 and M2 alleles are uncommon in healthy Caucasians and the $2 allele has been reported to be associated with coronary atherosclerosis at least in local Caucasian populations (Ferns et al, 1985;Rees et aL, 1985;Ferns and Galton, I986;Deeb et al, 1986;Acton et al, 1986). The results of the present study indicate that both the $2 and M2 alleles are common in healthy Japanese.…”

Section: Discussionmentioning

confidence: 99%

“…The human apo AI and apo CIII genes are tightly linked and form a gene complex together with the apo AIV gene on the long arm of the chromosome 11 (Karathanasis et al, 1983;Law et al, 1984;Cheung et al, 1984;Karathanasis, 1985;Elshourbagy et al, 1986). Restriction fragment length polymorphisms related to the apo AI and apo CIII genes have been reported to be associated with coronary atherosclerosis in Caucasians (Ferns et al, 1985;Rees et aI., 1985;Ferns and Galton, 1986;Ordovas et al, 1986;Buraczynska et al, 1986). An apo AI-CIII gene polymorphism associated with coronary atherosclerosis is likely to be a linkage marker for a deleterious atherogenic gene in the apo AI-CIII-AIV gene complex.…”

Section: Introductionmentioning

confidence: 99%

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Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

et al. 1986

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SummaryApolipoprotein (apo) CIII Sst-I genotypes and apo AI Msp-I genotypes were investigated in 82 unrelated healthy Japanese, using genomic hybridization analysis with a 2.2 kb fragment of the human apo AI gene. The frequencies of the $2 and M2 alleles were 0.34 and 0.40, respectively, and much higher than those in Caucasians. The alleles identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms were observed to be in linkage disequilibrium (A=0.206+0.012, p<0.001). Three of the four possible haplotypes were identified: the frequencies of the haplotype were S1-M1=0.604, $2-M2=0.341, and S1-M2=0.055. The data indicate that Japanese are characterized by the common presence of the haplotype $2-M2 as compared with Caucasians and that the haplotypes identified by the apo CIII Sst-I and apo AI Msp-I polymorphisms are useful genetic markers for Japanese.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

et al. 1986

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“…Most of these studies found a relationship between the presence of $2 allele and hypertriglyceridemia (2)(3)(4)(5)(6)9,11,(13)(14)(15)(16)18,(20)(21)(22). An association of this allele with CAD was also reported (26)(27)(28). PauI-Hayase et al (29) conducted a study on the Sstl polymorphism on Asian Indians residing at U. K. ($2=0.19).…”

Section: ) Genotypic Distribution Was In Agreement Withmentioning

confidence: 99%

Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

Chhabra

Agarwal²,

Vasisht

et al. 2003

Indian J Clin Biochem

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Several studies including a small case-control (hypertriglyceridemic / normotriglyceridemic individuals) study by us revealed close association between rare $2 allele of APOC3 Sstl polymorphism and hypertriglyceddemia. With the understanding that Asian Indians are highly vulnerable to the adverse effects of hypertdglyceridemia, we extended the investigation and studied the frequency distribution of this polymorphism in 216 healthy volunteers from Northern plains of India. We found that more than 50% of the study population had one ortwo $2 allele. This may suggest that a larger fraction of this population is genetically predisposed to hypertdglyceddemia.

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“…The results of the previous reports on the relationship of apo-CIII with hypertriglyceridemia and CHD in the Caucasian population of Southern England [1][2][3][4] could not be corroborated in the later findings on Scottish, 9 Scandinavian 10 and Japanese populations. 11 However, recent studies 12 have again found an association of apo-CIII marker with hypertriglyceridemia in Caucasians and West Japanese, establishing that the presence of the restriction site for Sac I is a marker for this type of dyslipidemia in these two populations.…”

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confidence: 67%

“…Polymorphism in the apoprotein gene cluster Al-CIII-AIV, located tandemly on chromosome 11, has drawn considerable attention for its association with hypertriglyceridemia, 1,2 other diverse hyperlipidemias, 3 myocardial infarction, 4,5 coronary heart disease 6,7 (CHD), and with the plasma LDL cholesterol response to dietary fat. 8 Of direct interest to us were the recently reported results on the Kuwaiti Arab population, showing close association of a single-base substitution from C to G (resulting in the creation of a Sac I restriction site) in the 3' untranslated region of the gene for apoprotein C-III (apo-CIII) with hypertriglyceridemia and CHD.…”

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Polymorphism in Apoprotein-CIII Gene and Coronary Heart Disease

et al. 1999

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Background:The aim of this study was to look into the association, if any, of apoprotein-CIII variant allele with hypertriglyceridemia, hypercholesterolemia and coronary heart disease (CHD). Patients and Methods:The prevalence of a C to G substitution in the 3' untranslated region of apoprotein-CIII was studied in a sample of 92 angiographed Saudi subjects, consisting of 65 males and 27 females. The subjects were genotyped by amplification followed by digestion of the gene fragment containing the polymorphic site with Sac I restriction enzyme. Results: The variant allele of apoprotein-CIII was found to be associated neither with hypertriglyceridemia nor with hypercholesterolemia. However, a significant association of this allele (P<0.01) was found with coronary heart disease, independent of other risk factors such as smoking, diabetes and hypertension. An estimation of odds ratio using logistic regression with various risk factors in the model showed that the individuals with this rare allele were 3.4 times more at risk of developing coronary heart disease. This estimate of risk held even after analyzing a subset of individuals above 45 years of age. Conclusion: While the association between apoprotein-CIII variant allele and dyslipidemia could not be established in this study, the relationship between this marker and CHD was highlighted in the studied subjects.

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Genetic Polymorphisms of Apolipoprotein C-Iii and Insulin in Survivors of Myocardial Infarction

Cited by 103 publications

References 15 publications

Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

Apolipoprotein AI-CIII gene polymorphisms in a Japanese population

Study of apolipoproteinc3 Sstl polymorphism in healthy volunteers from Northern India

Polymorphism in Apoprotein-CIII Gene and Coronary Heart Disease

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