Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer

Wu, Yuzhang; Hao, Xiaoxiong; Feng, Zijian; Liu, Yunsheng

doi:10.1007/s12013-014-0195-y

Cited by 16 publications

(10 citation statements)

References 36 publications

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“…Rs11614913 (T>C) is a common variant in pre-miR-196a2 that plays a role in the development of multiple cancer types, including gastric cancer (Peng et al, 2014;Ni et al, 2015;Nikolić et al, 2015;Qi et al, 2015;Wu et al, 2015). Several studies have evaluated the effect of this polymorphism on gastric cancer risk in different populations, but the results are inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

Bai

et al. 2016

Genet. Mol. Res.

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ABSTRACT. We did a case-control study to provide a more comprehensive evaluation of the association of the pre-miR-196a2 rs11614913 polymorphism with gastric cancer. Between January 2013 and December 2014, 182 patients newly diagnosed with primary gastric cancer and 182 control subjects were recruited at Zhengzhou People's Hospital. For SNP genotyping, we used the Assay Designer 3.1 to design the primers of polymerase chain reaction. Using the chisquare test, we found that patients with gastric cancer were more likely to be alcohol drinkers (c 2 = 4.4, P = 0.04), to have a family history of cancer in the first relatives (c 2 = 5.29, P = 0.02), and to be infected with Helicobacter pylori (c 2 = 23.39, P < 0.001). A significant difference in the genotype distributions of rs11614913 was observed in our study (c 2 = 6.66, P = 0.04). By logistic regression analysis, we found that the CC genotype of rs11614913 was associated with an increased risk of gastric cancer in a codominant model (OR = 2.68, 95%CI = 1.17-6.44). By stratification analysis, we found that the CC genotype was associated with a strongly increased risk of gastric cancer in drinkers when compared with the TT+TC genotype (OR = 5.63, 95%CI = 1.54- 30.76). In conclusion, the results of our study suggest an association between the rs11614913 gene polymorphism and an elevated risk of gastric cancer, especially in drinkers.

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Section: Introductionmentioning

confidence: 99%

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

Bai

et al. 2016

Genet. Mol. Res.

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“…For example, polymorphism rs2910164 has been associated with increased risk of breast cancer in two independent case-control studies in Chinese populations [ 16 , 17 ]. Similarly, polymorphism rs11614913 has been associated with increased risk of colorectal cancer in two independent meta-analyses in Asian population [ 18 , 19 ]. However, due to a small number of studies it is not possible to draw conclusions about the consistency of the results in other ethnic groups.…”

Section: Resultsmentioning

confidence: 99%

MicroRNA Polymorphisms in Cancer: A Literature Analysis

Pipan¹,

Zorc²,

Kunej³

2015

Cancers

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Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) genes (miR-SNPs) have attracted increasing attention in recent years due to their involvement in the development of various types of cancer. Therefore, a systematic review on this topic was needed. From 55 scientific publications we collected 20 SNPs, which are located within 18 miRNA encoding genes and have been associated with 16 types of cancer. Among 20 miRNA gene polymorphisms 13 are located within the premature miRNA region, five within mature, and two within mature seed miRNA region. We graphically visualized a network of miRNA-cancer associations which revealed miRNA genes and cancer types with the highest number of connections. Our study showed that, despite a large number of variations currently known to be located within miRNA genes in humans, most of them have not yet been tested for association with cancer. MicroRNA SNPs collected in this study represent only 0.43% of known miRNA gene variations (20/4687). Results of the present study will be useful to researchers investigating the clinical use of miRNAs, such as the roles of miRNAs as diagnostic markers and therapeutic targets.

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“…While the pooled data from Du et al's meta-analysis supported that the miR-196a2 rs11614913 and miR-149 rs2292832 polymorphisms may contribute to susceptibility to CRC [ 26 ]. The latest meta-analysis, which related to the associations between miRNA polymorphisms and colorectal cancer, performed by Wu et al indicated that SNP rs11614913 but not SNP rs2910164 and SNP rs2292832 may contribute to susceptibility to CRC in an Asian-specific manner [ 27 ]. This result was unconformable with our results.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk

Liu

Meng

et al. 2015

BioMed Research International

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Background. The associations between polymorphisms in microRNAs and the susceptibility of colorectal cancer (CRC) were inconsistent in previous studies. This study aims to quantify the strength of the correlation between the four common polymorphisms among microRNAs (hsa-mir-146a rs2910164, hsa-mir-149 rs2292832, hsa-mir-196a2 rs11614913, and hsa-mir-499 rs3746444) and CRC risk. Methods. We searched PubMed, Web of Knowledge, and CNKI to find relevant studies. The combined odds ratio (OR) with 95% confidence interval (95% CI) was used to estimate the strength of the association in a fixed or random effect model. Results. 15 studies involving 5,486 CRC patients and 7,184 controls were included. Meta-analyses showed that rs3746444 had association with CRC risk in Caucasians (OR = 0.57, 95% CI = 0.34–0.95). In the subgroup analysis, we found significant associations between rs2910164 and CRC in hospital based studies (OR = 1.24, 95% CI = 1.03–1.49). rs2292832 may be a high risk factor of CRC in population based studied (OR = 1.18, 95% CI = 1.08–1.38). Conclusion. This meta-analysis showed that rs2910164 and rs2292832 may increase the risk of CRC. However, rs11614913 polymorphism may reduce the risk of CRC. rs3746444 may have a decreased risk to CRC in Caucasians.

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Genetic Polymorphisms in miRNAs and Susceptibility to Colorectal Cancer

Cited by 16 publications

References 36 publications

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

Association between the pre-miR-196a2 rs11614913 polymorphism and gastric cancer susceptibility in a Chinese population

MicroRNA Polymorphisms in Cancer: A Literature Analysis

Quantitative Assessment of the Association between Genetic Variants in MicroRNAs and Colorectal Cancer Risk

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