Genetic Polymorphisms in MicroRNA-196a2 and the Risk of Human Abortion Related to Mycoplasma hominis

Ivani, Zahra; Bagheri, Masoumeh; Zahmatkesh, Azadeh; Dadar, Maryam

doi:10.1007/s00284-022-03034-w

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“…Thus, individuals carrying LGALS13 rs2233706 AG or GG genotype and LGALS13 rs2233708 TA or AA genotype were found to have a greater risk of infection associated sPTB than those with the homozygous AA and TT genotype ( p < .0001) (Table 5 ) . Study revealed that genetic polymorphisms in microRNA‐196a2 gene induced the risk of recurrent abortion during Mycoplasma hominis infection 47 …”

Section: Resultsmentioning

confidence: 99%

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Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection‐associated spontaneous preterm birth

Bhati

Ray

Arora

et al. 2023

American J Rep Immunol

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ProblemSpontaneous preterm birth (sPTB) is a global health issue. Studies suggest infection and infection‐based inflammatory responses are major risk factors for sPTB. Considering the important role of anti‐inflammatory proteins in pregnancy, the study aimed to find the association between anti‐inflammatory LGALS13 gene variants IVS2‐22 A/G (rs2233706) and IVS3+72 T/A (rs2233708) and the risk of sPTB during Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum infection in Indian population.Method of studyPlacental samples of 160 sPTB and 160 term women were collected. Pathogens were detected by PCR. The genotyping of LGALS13 gene variants IVS2‐22 A/G (rs2233706) and IVS3+72 T/A (rs2233708) was done by qualitative real‐time PCR using allelic discrimination method (VIC‐ and FAM‐labeled).ResultsThe frequency of AG or GG genotype of LGALS13 IVS2‐22A/G polymorphism (rs2233706) was 75.5% in infected sPTB cases and 14.4% in uninfected sPTB cases and 7.3% in term birth controls (p < .0001), while the frequency of TA or AA genotype of LGALS13 IVS3+72T/A polymorphism (rs2233708) was 83.6% in infected sPTB cases and 18% in uninfected sPTB cases and 12.7% in term birth controls (p < .0001). The genotypic frequencies for both the variants of LGALS13 were statistically significant (p < .0001) in the infected sPTB versus uninfected sPTB and term birth controls.ConclusionsStudy reveals strong association between the presence of immunological gene variants LGALS13 IVS2‐22 A/G (rs2233706) and LGALS13 IVS3+72 T/A (rs2233708) and risk of sPTB during C. trachomatis, M. hominis and U. urealyticum infection.

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Section: Resultsmentioning

confidence: 99%

“…Study revealed that genetic polymorphisms in microRNA-196a2 gene induced the risk of recurrent abortion during Mycoplasma hominis infection. 47…”

Section: Association Between C Trachomatis M Hominis and U Urealyticu...mentioning

confidence: 99%

Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection‐associated spontaneous preterm birth

Bhati

Ray

Arora

et al. 2023

American J Rep Immunol

View full text Add to dashboard Cite

show abstract

Genetic Polymorphisms in MicroRNA-196a2 and the Risk of Human Abortion Related to Mycoplasma hominis

Cited by 1 publication

References 23 publications

Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection‐associated spontaneous preterm birth

Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection‐associated spontaneous preterm birth

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