Genetic polymorphisms in Kawasaki disease

Kuo, Ho‐Chang; Chang, Wei Chiao

doi:10.1038/aps.2011.93

Cited by 46 publications

(35 citation statements)

References 75 publications

(111 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been known that transforming growth factor-beta (TGF-b) is a candidate gene for KD pathogenesis because TGF-b-mediated T-cell activation and cardiovascular remodeling are considered as the most important characteristics of Kawasaki disease [22]. CASP3 is a key molecule of activation-induced cell death, and it has been reported to interactive with IP3 (inositol 1, 4, 5-triphosphosphate), which is a substrate for ITPKC (inositol 1, 4, 5-trisphosphate 3-kinase C) in T cells [23].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

Xing

Wang²,

Liu³

et al. 2014

Mol Biol Rep

View full text Add to dashboard Cite

Kawasaki disease is a pediatric systemic vasculitis of unknown etiology, for which a genetic influence is suspected. But whether single nucleotide polymorphism (SNP) of caspase-3 rs72689236 is associated with Kawasaki disease is controversial. The aim of our study is to assess the association between the SNP of caspase-3 and risk for Kawasaki disease. We searched PubMed, MEDLINE, EMBASE, Springer, Elsevier Science Direct, Cochrane Library Google scholar, CNKI (China National Knowledge Infrastructure, in Chinese) and Wanfang database (in Chinese) to identify studies investigating the association between rs72689236 polymorphism and Kawasaki disease occurrence. There were five eligible studies, which included 4,241 (case group 1,560; control group 2,681) participants in this meta-analysis. Pooled odds ratios (ORs) and 95 % confidence intervals (95 % CIs) were calculated in a fixed-effects model (the Mantel-Haenszel method) or a random-effects model (the DerSimonian and Laird method) when appropriate. Significant associations were found under the overall ORs for A-allele comparison (A vs. G, pooled OR 1.33, 95 % CI 1.21-1.46), AA versus GG comparison (pooled OR 1.64, 95 % CI 1.35-2.00), GA versus GG comparison (pooled OR 1.42, 95 % CI 1.24-1.63), recessive model (AA vs. GG + GA, pooled OR 1.37, 95 % CI 1.15-1.64) and dominant model (AA + GA vs. GG, pooled OR 1.47, 95 % CI 1.29-1.67). This meta-analysis suggested that SNP rs72689236 of caspase-3 might be associated with susceptibility of Kawasaki disease and the allele A might increase the risk of Kawasaki disease in Asian samples such as Japanese and Chinese. In addition, individual studies with large sample size are needed to further evaluate the associations in various ethnic populations.

show abstract

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

Xing

Wang²,

Liu³

et al. 2014

Mol Biol Rep

View full text Add to dashboard Cite

show abstract

“…Several lines of evidence have shown an imbalance between Th1 and Th2 immune reactions in KD patients. Th1 immune related responses (IFN-gamma, tumor necrosis factor-alpha, IL-1 β , and IL-10) [38, 39] and Th2 immune related responses (eosinophils, IL-4 [22], IL-5 [25, 26], eotaxin, and total IgE) have been reported to be associated with the susceptibility to KD and disease outcomes. Furthermore, serum IgE levels were shown to be increased in KD patients during the acute stage of the disease [34].…”

Section: Discussionmentioning

confidence: 99%

Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-Based Study in Taiwan

Woon

Chang

Liang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Kawasaki disease (KD) is an acute febrile systemic vasculitis and has been reported to be associated with allergic disease. The risk of atopic dermatitis (AD) in preschool children with KD has not been investigated. The study was to determine the longitudinal risk of the development of AD in preschool children with KD. A nationwide 5-year population-based study was performed using data from the National Health Insurance Database in Taiwan between 1999 and 2003. The risk factors for AD were compared between the 2 study groups during the follow-up period using the Cox proportional hazards model. In addition, plasma interleukin (IL)-5 levels were analyzed in normal subjects and KD patients. Among the 1440 subjects included, 21.6% developed AD during the 5-year follow-up period, of which 30.3% and 18.7% belonged to the study cohort and the comparison group, respectively. Children with KD were 1.25 times more likely to have AD than those in controls (P = 0.04). Levels of IL-5 and IgE were significantly higher in KD patients. Children with KD had a higher risk of developing AD during the 5-year follow-up period than the control group. Increased IL-5 and IgE levels may be key factors contributing to the risk of AD.

show abstract

“…Genetics might play an important role in the pathogenesis of KD (26). Genome-wide association study for KD was firstly performed by Burgner et al (27).…”

Section: Discussionmentioning

confidence: 99%

TARC/CCL17 gene polymorphisms and expression associated with susceptibility and coronary artery aneurysm formation in Kawasaki disease

et al. 2013

Self Cite

View full text Add to dashboard Cite

Background: Kawasaki disease (KD) is a systemic vasculitis of unknown etiology. Thymus and activation-regulated chemokine/chemokine ligand 17 (TARC/CCL17) is one of the Th2 chemokines and has been suggested as a candidate gene for conferring susceptibility to Th2 associated with allergy diseases. This study examined the correlation between gene polymorphisms and plasma levels of TARC/CCL17 in patients with KD and the outcomes of KD. Methods: A total of 381 KD patients and 564 controls were subjected to determination of five tagging single-nucleotide polymorphisms of TARC/CCL17. In addition, plasma TARC/ CCL17 levels were measured by enzyme-linked immunosorbent assay. results: Polymorphisms of TARC/CCL17 were significantly different between normal children and patients with KD. A allele of rs4784805 has better intravenous immunoglobulin (IVIG) treatment response to KD. Furthermore, plasma TARC/ CCL17 levels were higher in KD patients than that in controls before IVIG treatment. After IVIG treatment, plasma TARC/ CCL17 levels decreased significantly. conclusion: This study provides the first evidence supporting the association between TARC/CCL17 polymorphisms, susceptibility of KD, and IVIG responses in KD patients. k awasaki disease (KD), also known as mucocutaneous lymph node syndrome, is an acute febrile systemic vasculitis that was first described by Kawasaki et al. in 1974 in English (1), but its etiology remains unknown till now. It occurs most commonly in children younger than 5 y of age, particularly in children younger than 2 y of age, and the clinical presentation of KD is prolonged fever, conjunctivitis, diffuse mucosal inflammation, polymorphous skin rashes, indurative edema of the hands and feet associated with peeling of finger tips, and nonsuppurative lymphadenopathy (2). In developed countries, KD has been the leading cause of acquired heart diseases in children (2,3). The most serious complication of KD is the occurrence of coronary artery lesions (CALs), including myocardial infarction, coronary artery fistula formation (4), coronary artery dilation, or coronary artery aneurysm (CAA) (5). In addition, KD is the major cause of acquired CAA in childhood (6). The prevalence of KD in children is the highest in Japan, followed by Korea and Taiwan, and the lowest in Europe (5). Therefore, it is possible that a genetic background plays an important role in the pathogenesis of KD.Thymus and activation-regulated chemokine/chemokine ligand 17 (TARC/CCL17) is a member of the CC chemokine group (7). It is a ligand of the CC chemokine receptor (8), which is selectively expressed on Th2 cells (9) and serves for the recruitment and migration of cells bearing this receptor (7-9). TARC/CCL17 has been suggested as a candidate gene for conferring susceptibility to Th2 associated with allergy diseases and is highly implicated in the pathogenesis of atopic dermatitis (10,11) and bronchial asthma (12). There are several lines of evidence pointing out an abnormal Th1/Th2 balance in KD patients (13). Recently, it has b...

show abstract

Genetic polymorphisms in Kawasaki disease

Cited by 46 publications

References 75 publications

RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

Increased Risk of Atopic Dermatitis in Preschool Children with Kawasaki Disease: A Population-Based Study in Taiwan

TARC/CCL17 gene polymorphisms and expression associated with susceptibility and coronary artery aneurysm formation in Kawasaki disease

Contact Info

Product

Resources

About