RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

Xing, Yun; Wang, H; Liu, Xiaoyu; Yu, Xinguang; Chen, R; Wang, C; Sun, Lei

doi:10.1007/s11033-014-3517-7

Cited by 7 publications

(3 citation statements)

References 20 publications

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“…Although the efforts to find a causative microorganism have failed [2][3][4] , the suspicion of an association between some unidentified microorganism and Kawasaki disease remains [4][5][6][7] . Investigations to identify a genetic susceptibility locus in Kawasaki disease also have been performed recently [8][9][10] . Several institutes had cooperated and reported a result regarding the genetic susceptibility of Kawasaki disease [11] .…”

Section: Introductionmentioning

confidence: 99%

Use of corticosteroids during acute phase of Kawasaki disease

Yu¹

2015

WJCP

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In spite of initial intravenous immunoglobulin (IVIG) treatment, a significant number of patients are unresponsive to it and are at a higher risk for coronary artery lesions. Corticosteroids have been used as a secondary drug or used in combination with IVIG. Three options of using corticosteroids for the treatment of patients during the acute phase of Kawasaki disease, have been considered. The first is their use exclusively for patients unresponsive to IVIG treatment. The second is their use in combination with IVIG as the routine first line therapy for all patients. The last is the use in the combination as the first line therapy for selected patients at a high risk being unresponsive to initial IVIG. However, it is uncertain that the corticosteroids as the second line treatment are better than the additional IVIG in patients unresponsive to initial IVIG. The combination of corticosteroids and IVIG as the routine first line therapy also have not enough evidences. The last option of using corticosteroids - the combination of corticosteroids and IVIG in patients at high risk of unresponsiveness, is a properly reasonable treatment strategy. However, there have been no globally standardized predictive models for the unresponsiveness to initial IVIG treatment. Therefore, future investigations to determine the best predictive model are necessary.

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Section: Introductionmentioning

confidence: 99%

Use of corticosteroids during acute phase of Kawasaki disease

Yu¹

2015

WJCP

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“…This has led to speculation that the genetic variations between differing ethnic groups may account for the significant ethnic disparity in KD rates. Several susceptibility loci in KD have been identified through the meta-analysis of previous genome-wide association study (GWAS) investigations, such as BLK , CASP3 , CD40 , FCGR2A , HLA-DOB , and ITPKC [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. However, these genetic susceptibility markers confer risk to KD development in a passive manner [ 19 ], and therefore sensitize individuals to the currently unknown environmental agents that induce KD in susceptible children [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children

Yeter

Portman

Aschner

et al. 2016

IJERPH

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Kawasaki disease (KD) primarily affects children <5 years of age (75%–80%) and is currently the leading cause of acquired heart disease in developed nations. Even when residing in the West, East Asian children are 10 to 20 times more likely to develop KD. We hypothesized cultural variations influencing pediatric mercury (Hg) exposure from seafood consumption may mediate ethnic KD risk among children in the United States. Hospitalization rates of KD in US children aged 0–4 years (n = 10,880) and blood Hg levels in US children aged 1–5 years (n = 713) were determined using separate US federal datasets. Our cohort primarily presented with blood Hg levels <0.1 micrograms (µg) per kg bodyweight (96.5%) that are considered normal and subtoxic. Increased ethnic KD risk was significantly associated with both increasing levels and detection rates of blood Hg or cadmium (Cd) in a linear dose-responsive manner between ethnic African, Asian, Caucasian, and Hispanic children in the US (p ≤ 0.05). Increasing low-dose exposure to Hg or Cd may induce KD or contribute to its later development in susceptible children. However, our preliminary results require further replication in other ethnic populations, in addition to more in-depth examination of metal exposure and toxicokinetics.

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“…Apoptosis is considered an essential biological event, which is modulated by the activation of multiple caspases, including caspase‐3, and plays a crucial role in cellular and tissue homeostasis. Thus, the inappropriate regulation of apoptosis might be one of the most important factors in influencing the development and progression of many diseases [13,14]. Therefore, it seemed biologically plausible that genetic alterations of Caspase‐3 might be involved in the failure of apoptosis, which might lead to human diseases such as LDH [15–17].…”

Section: Introductionmentioning

confidence: 99%

Associations of Caspase‐3 gene polymorphism with lumbar disc herniation

Fang

Qiu

Jiang

et al. 2016

The Kaohsiung J of Med Scie

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To investigate Caspase-3 gene polymorphisms (rs4647693 G/A, rs4647610 A/G, and rs12108497 T/C) and susceptibility to lumbar intervertebral disc herniation (LDH). The genotype frequency distributions of the polymorphisms were detected by polymerase chain reaction-restriction fragment length polymorphism in 107 LDH patients (case group) and 121 healthy individuals (control group). SHEsis software was used to conduct gene linkage disequilibrium and haplotype analysis. Regression analysis was used to analyze possible risk factors for LDH. Statistically significant differences in family history of LDH, amateur sports, leisure activities, bed types, and spine load grade were found between the case and control groups. The distribution of allele and genotype frequencies of rs4647693 G/A, rs4647610 A/G, and rs12108497 T/C polymorphisms of Caspase-3 were significantly different between the case and control groups. Haplotype analysis showed that the G-G-C (rs4647693-rs4647610-rs12108497) haplotype might be a risk factor for LDH, whereas the A-A-T haplotype might be a protective factor (p < 0.05). Binary logistic regression analysis showed that the GA+AA genotype of rs4647693 was negatively associated with the risk of LDH, whereas high spine load grade was positively associated with the risk of LDH. These findings revealed that rs4647693 G/A, rs4647610 A/G, and rs12108497 T/C polymorphisms of Caspase-3 may be associated with susceptibility to LDH and that interaction and modification effects may exist between Caspase-3 polymorphisms.

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RETRACTED ARTICLE: Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease

Cited by 7 publications

References 20 publications

Use of corticosteroids during acute phase of Kawasaki disease

Use of corticosteroids during acute phase of Kawasaki disease

Ethnic Kawasaki Disease Risk Associated with Blood Mercury and Cadmium in U.S. Children

Associations of Caspase‐3 gene polymorphism with lumbar disc herniation

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