Genetic polymorphisms in anti-inflammatory cytokine signaling and the prevalence of gastric precancerous lesions in Venezuela

Abstract

While the results of the present study suggest roles of genetic variability in these anti-inflammatory mediators in different stages of gastric carcinogenesis, there is high likelihood that they were chance findings due to multiple comparisons.

Interleukin-4 and -8 Gene Polymorphisms and Risk of Gastric Cancer in a Population in Southwestern China

“…The IL-4-590 C>T polymorphism was not associated with either overall or subtype GC. This finding concerning overall GC risk was in agreement with that from studies in Chinese Taiwan (Wu et al, 2003;Lai et al, 2005), Spain (Garcia- Gonzalez et al, 2007), and Venezuela (Kato et al, 2006). Of note, the risk of the polymorphism remained nonsignificant even in a case-control analysis for HP infected patients and controls in a Japanese population (Ando et al, 2009).…”

“…Of note, the risk of the polymorphism remained nonsignificant even in a case-control analysis for HP infected patients and controls in a Japanese population (Ando et al, 2009). We observed that T was a dominant allele in Asian populations (Wu et al, 2003;Lai et al, 2005;Ando et al, 2009), but a minor one in European and African populations (Kato et al, 2006;Garcia-Gonzalez et al, 2007). Despite distinct allele and genotype frequencies, the negative association with GC is, however, consistent among different populations.…”

Genetic Factors Involved in the Genesis of Helicobacter Pylori-Induced Gastric Cancer

“…One study of Venezuelan subjects revealed that those with homozygotes with the low activity allele (GG) of the A398G polymorphism in the IL-4R gene (rs1805010) had a modestly increased risk of gastric atrophy (OR = 1.52, 95% CI = 1.05-2.21) (Kato et al, 2006), suggesting the role of genetic variability in the anti-inflammatory mediators in the genesis of H. pylori-induced gastric precancerous lesions. iNOS C150T (rs2297518) and PRKCH rs3783799 G/A polymorphisms: PRKCH is shown to be involved in oxidative stress, by activating iNOS and nitric oxide production (Pham et al, 2003).…”

“…IL-4 T-590C 5'UTR rs2243250 1,301 Venezuelan (Kato, 2006) TT ,CT :0.82,CC :0.81 IL-4R C-3223T 5'UTR rs2057768 1,301 Venezuelan (Kato, 2006) CC ,CT :0.97,TT :1.01…”

“…Non-synonimous (Ile50Val) rs1805010 1,301 Venezuelan (Kato, 2006) AA ,AG :1.14,GG :1.52* IL-6 G-174C 5'UTR rs1800795 1,315 Venezuelan (Kato, 2007) GG ,CG :0.98,CC : 0.57…”