Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients

Szeto, Cheuk‐Chun; Chow, Kai‐Ming; Poon, P.W.F.; Szeto, Carol Yi-Ki; Wong, Teresa Yuk‐Hwa; Li, Philip Kam-Tao

doi:10.1111/j.1523-1755.2004.00605.x

Cited by 71 publications

(61 citation statements)

References 40 publications

(22 reference statements)

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“…The CC genotype of VEGF RS3025039 is shown to be associated with higher VEGF levels in the Bahraini population [32]. The CC genotype for VEGF RS699947 was shown to be associated with higher VEGF protein levels in a study on peritoneal dialysis patients [33]. The race distribution in these data was not described and, therefore, may be different from our population.…”

Section: Discussioncontrasting

confidence: 42%

Can Functional Polymorphisms in VEGF and MMP Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Prasun¹,

Madan²,

Puthuraya³

et al. 2018

Dev Neurosci

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Background: The pathophysiology of intraventricular hemorrhage (IVH) is multifactorial. This study attempts to identify genetic and clinical factors contributing to IVH in newborns with a focus on those born ≤28 weeks of gestation. Methods: This was a prospective study of 382 consecutive newborns admitted to the neonatal intensive care unit. DNA purification was conducted using standard methods. TaqMan SNP assays were conducted for functional polymorphisms in VEGF (RS699947, RS2010963, RS3025039, and RS1570360) and MMP2 (RS243685 and RS2285053) genes. An RFLP assay was done for a polymorphism in MMP9 (RS3918242). Results: The GG genotype in VEGF RS1570360 (p = 0.013) and the CC genotype in VEGF RS699947 (p = 0.036) were associated with a lower incidence of IVH amongst newborns ≤28 weeks of gestation. Chorioamnionitis, Caucasian race, and patent ductus arteriosus were associated with a higher incidence of IVH. A binary logistic regression analysis of clinical and SNP data that was significant from bivariate analysis demonstrated that VEGF RS1570360 was significantly associated with IVH (p = 0.017). Conclusion: This study demonstrated that the GA/AA genotype in VEGF RS1570360 and the AA/AC genotype in VEGF RS699947 were associated with higher incidence rates of IVH in newborns ≤28 weeks of gestation. A future study is warranted to comprehensively examine VEGF polymorphisms in association with IVH.

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Section: Discussioncontrasting

confidence: 42%

Can Functional Polymorphisms in VEGF and MMP Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Prasun¹,

Madan²,

Puthuraya³

et al. 2018

Dev Neurosci

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“…Among them, the VEGF -2578C/A has been shown to functionally affect the mRNA level of VEGF. The VEGF -2578C/A polymorphism has been proven to be associated with many diseases, such as lung carcinoma, atherosclerosis, Alzheimer's disease, peritoneal membrane function, graft survival, and breast cancer [41,42,43,44,45,46]. Furthermore, it was reported further that VEGF -2578C/A is associated both with type 1 diabetes and acceleration of its onset [47].…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of Association between the -2578C/A Polymorphism of the Vascular Endothelial Growth Factor and Retinopathy in Type 2 Diabetes in Asians and Caucasians

Wang

Cheng²,

Zhu³

et al. 2014

Ophthalmic Res

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Background and Objectives: Vascular endothelial growth factor (VEGF) has been shown to play an important role in the development and progress of diabetic retinopathy (DR). A number of case-control studies focused on the association between VEGF -2578C/A and risk for DR. But the results were not always consistent, so we performed a meta-analysis to evaluate the precise association between this variant and risk for DR. Methods: All publications on the association between VEGF -2578C/A polymorphism and DR were searched in the following electronic databases: PubMed, Embase, the Cochrane Library and Chinese Biomedical Literature Database, with the last report up to January 2013. This meta-analysis was assessed by Review Manager 5.1. Results: A total of 6 studies were involved in this meta-analysis, including 835 cases and 867 controls. Overall, we found a significant association between this polymorphism and DR (A vs. C: OR = 1.49, 95% CI = 1.26-1.77, p < 0.00001; AA vs. CA + CC: OR = 1.26, 95% CI = 0.94-1.68, p = 0.12; AA + CA vs. CC: OR = 1.56, 95% CI = 1.27-1.91, p < 0.00001; AA vs. CC: OR = 1.67, 95% CI = 1.20-2.32, p = 0.003; CA vs. CC: OR = 1.51, 95% CI = 1.21-1.87, p = 0.0002), but we did not find any significant association in Caucasians in subgroup analysis. The results were not materially altered after the studies which did not fulfill the Hardy-Weinberg equilibrium were excluded. Conclusion: Our meta-analysis supports the association between the VEGF -2578C/A polymorphism and DR, but not in the Caucasian population.

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“…Anti-VEGF-A antibodies can ameliorate the increase in solute transport, the expression of adhesion molecules [21] , and the anatomical changes induced by peritonitis or bio-incompatible dialysate [11] . Polymorphism of the VEGF-A gene predicts the change in PET during long-term follow-up [22] . In our study, we found that dialysate VEGF-C and IL-6 correlated with PET, but not VEGF-A.…”

Section: Discussionmentioning

confidence: 99%

Intraperitoneal Vascular Endothelial Growth Factor C Level Is Related to Peritoneal Dialysis Ultrafiltration

Yang

Tsai²,

Shih³

et al. 2009

Blood Purif

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Background: Local inflammation and neovascularization have a negative influence on peritoneal dialysis (PD). Patients with higher peritoneal transport have higher interleukin-6 (IL-6) and vascular endothelial growth factor-A (VEGF-A) levels in their dialysate. However, the relationship of other members of the VEGF family, such as VEGF-C, to peritoneal transport or ultrafiltration (UF) is yet to be studied. Methods: Peritoneal cytokine and growth factor levels were determined during the peritoneal equilibration test (PET). Ultrafiltration, peritoneal clearance and residual renal function were also considered. Results: Forty-two PD patients were enrolled. They had been on PD for at least 1 month and free of peritonitis for at least 1 month prior to the study. Patients with high or high average PET had higher dialysate IL-6 and VEGF-C. Dialysate IL-6 and VEGF-C correlated negatively with PET and UF. Conclusions: Dialysate VEGF-C is related to higher transport rate and poorer UF. The role of VEGF-C in PD deserves further study.

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Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients

Cited by 71 publications

References 40 publications

Can Functional Polymorphisms in <b><i>VEGF</i></b> and <b><i>MMP</i></b> Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Can Functional Polymorphisms in <b><i>VEGF</i></b> and <b><i>MMP</i></b> Predict Intraventricular Hemorrhage in Extremely Preterm Newborns?

Meta-Analysis of Association between the -2578C/A Polymorphism of the Vascular Endothelial Growth Factor and Retinopathy in Type 2 Diabetes in Asians and Caucasians

Intraperitoneal Vascular Endothelial Growth Factor C Level Is Related to Peritoneal Dialysis Ultrafiltration

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