Intraperitoneal Vascular Endothelial Growth Factor C Level Is Related to Peritoneal Dialysis Ultrafiltration

Abstract

Background: Local inflammation and neovascularization have a negative influence on peritoneal dialysis (PD). Patients with higher peritoneal transport have higher interleukin-6 (IL-6) and vascular endothelial growth factor-A (VEGF-A) levels in their dialysate. However, the relationship of other members of the VEGF family, such as VEGF-C, to peritoneal transport or ultrafiltration (UF) is yet to be studied. Methods: Peritoneal cytokine and growth factor levels were determined during the peritoneal equilibration test (PET). Ultrafiltration, peritoneal clearance and residual renal function were also considered. Results: Forty-two PD patients were enrolled. They had been on PD for at least 1 month and free of peritonitis for at least 1 month prior to the study. Patients with high or high average PET had higher dialysate IL-6 and VEGF-C. Dialysate IL-6 and VEGF-C correlated negatively with PET and UF. Conclusions: Dialysate VEGF-C is related to higher transport rate and poorer UF. The role of VEGF-C in PD deserves further study.

TGF-β1 Promotes Lymphangiogenesis during Peritoneal Fibrosis

“…Our data are consistent with the recent report by Yang et al, 41 which showed that VEGF-C could possibly be a biomarker for UFF; however, unlike our study, they did not investigate lymphangiogenesis. Our studies of human peritoneal membranes showed that VEGF-C, LYVE-1, and podoplanin mRNA expression were higher in UFF peritoneum than control membranes and that the expression level of VEGF-C and the number of lymphatic vessels correlated with one another.…”

Effects of recombinant human endostatin on peritoneal angiogenesis in peritoneal dialysis rats

“…Vascular endothelia growth factor and bFGF, respectively, played an important role in the process of peritoneal angiogenesis and fibrosis. As reported, both of them have correlated with the peritoneal ultrafiltration functions 8,9 . Jiangzi et al 10 .…”

Connective tissue growth factor is correlated with peritoneal lymphangiogenesis

“…In this study, we first explored whether the CTGF concentration was positively correlated with the VEGF-C concentration in human PD effluents. Both CTGF and VEGF-C protein in human dialysate are correlated with peritoneal permeability 13,18,37 , suggesting that both could be biomarkers and therapeutic targets for UFF. The dialysate protein level is affected by local peritoneal production and transfer from the blood circulation, which is also dependent on several factors including the plasma level 38 , peritoneal protein clearance 39 , molecular weight with degradation 18 , and protein charge 40 .…”