Genetic polymorphism of the <i>interferon</i>‐γ gene in cervical carcinogenesis

Lai, Hung Cheng; Chang, Cheng‐Chang; Lin, Yu-Shen; Chen, Su Feng; Mu, Yu; Nieh, Shin; Chu, Ta Wei; Chu, T. Ming

doi:10.1002/ijc.20637

Cited by 30 publications

(12 citation statements)

References 33 publications

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“…Polymorphisms are frequent in the promoter region of the IFNG gene and affect the level of IFN-␥ normally produced in the body (32,33). Recent reports attempt to establish a correlation between certain IFNG polymorphisms and susceptibility to various diseases, including human papillomavirus-induced cervical cancer (24), tuberculosis (26), and parvovirus B19 infections (22). It is possible that kidney transplant patients with IFNG polymorphisms resulting in lower levels of IFN-␥ production are naturally more susceptible to reactivation of BKV under immunosuppressive therapies.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Gamma Interferon on BK Virus Gene Expression and Replication

Abend

Low

Imperiale

2007

J Virol

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Polyomavirus nephropathy (PVN) results in renal dysfunction and graft loss in up to 10% of all kidney transplant recipients (18). It is widely accepted that BK virus (BKV) is the etiological agent responsible for the majority of cases of PVN, which are typically diagnosed within the first year after transplantation (19,20). PVN is characterized by the lytic, destructive replication of BKV in proximal tubule epithelial cells in the transplanted kidney and is normally diagnosed by renal biopsy to assess histological effects of infection, PCR to determine viral presence and loads in the urine and blood, and the detection of decoy cells, which are cells with distinct intranuclear inclusion bodies that are shed during active BKV replication, in the urine (reviewed in references 10, 17, and 30). Since there are currently no effective antiviral treatments for BKV infection, the most common approach used to control PVN is to decrease the patient's immunosuppressive regimen. However, such an approach increases the risk of graft rejection and thus is not an appealing strategy. The prevalence of PVN is increasing with the advent of new, more powerful immunosuppressive therapies, making it a growing concern for the transplant community.The human polyomavirus BKV was first isolated in 1971 in the urine of a renal transplant recipient (11). BKV virions are small (40 to 45 nm in diameter), nonenveloped, and icosahedral and contain a circular, double-stranded DNA genome of approximately 5.2 kb (reviewed in reference 29) which is associated with cellular histones to form a chromatin-like structure (28). The genome encodes only six known proteins: the early proteins, large tumor antigen (TAg) and small tumor antigen, and the late proteins, VP1, VP2, VP3, and agnoprotein. BKV infects nearly the entire population, with seroprevalence reaching 60 to 80% by the age of 10 (reviewed in reference 23). BKV is thought to be contracted by respiratory transmission, and the primary infection is typically subclinical. Following the initial infection, BKV spreads to other cells of the body, most notably peripheral blood mononuclear cells (9) and cells of the kidney and urinary tract (4,16,39), in which the virus establishes a persistent, subclinical infection. It is at these sites in immunocompromised patients that BKV reactivates to a lytic infection, resulting in BKV-associated diseases, such as PVN.Previously, we described an in vitro system that allows the study of BKV lytic infection of primary human proximal tubule epithelial cells (27). The functions of proximal tubule cells in the kidney include facilitation of the recovery of blood products, maintenance of blood pressure and volume, and production and release of cytokines and chemokines to communicate with the host immune system (2, 6). Proximal tubule cells remain in a differentiated state for up to six passages in tissue culture (21) and thus provide an environment similar to that which BKV encounters in an immunocompromised host. By introducing individual elements of the immune sys...

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Section: Discussionmentioning

confidence: 99%

Inhibitory Effect of Gamma Interferon on BK Virus Gene Expression and Replication

Abend

Low

Imperiale

2007

J Virol

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“…A significant association was observed between interferon-ɤ gene polymorphisms and systemic lupus erythematosus suggesting that elevated interferon-ɤ is associated with increased systemic erythematosus susceptibility [56]. Lai et al reported that genetic polymorphism of IFN-ɤ gene is associated with individual susceptibility to cervical carcinogenesis [57]. Feher et al could not find any association between IFN-γ +874 A/T gene polymorphism and Alzheimer disease [58].…”

Section: Discussionmentioning

confidence: 90%

Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

Sobhy¹,

Sedrak²,

Hashad³

et al. 2012

Our Dermatol Online

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“…30 Lai et al reported that genetic polymorphism of IFN-gamma gene is associated with individual susceptibility to cervical carcinogenesis. 31 Feher et al could not find any association between IFN-γ +874 A/T gene polymorphism and Alzheimer disease. 32 Our study found a significant association of ‘TT’ genotype of IFN-γ +874 gene polymorphism and ischemic stroke in South Indian population.…”

Section: Discussionmentioning

confidence: 94%

Interferon gamma (IFNγ) +874A/T gene polymorphism in South Indian ischemic stroke patients

Sultana

Venkata

Pranay³

et al. 2011

ANS

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BackgroundIschemic stroke is a complex vascular and metabolic process resulting in neuronal death and progression with time. Cytokines play a role in immune response and also maintains the normal homeostatic environment of the central nervous system. IFN-γ is one of the key effector cytokines produced by NK and T cells that enhances microbicidal activity of macrophages and neutrophils.PurposeAs the association of IFNγ +874A/T gene polymorphism with stroke has not been investigated in Indian population, we wanted to evaluate the association of this polymorphism with ischemic stroke in a South Indian population.MethodsWe genotyped 171 ischemic stroke patients and 153 age-matched control subjects.ResultsStatistical analysis showed a significant association of TT homozygote with ischemic stroke (OR=1.9, 95% CI=1.05-3.43, p=0.03), while AA (OR= 0.84, 95% CI=0.54–1.31, p=0.46) and AT(OR=0.80, 95% CI=0.51-1.26, p=0.34) genotypes were not significantly associated. A and T allele frequencies in stroke were 58.78% and 41.22% as against 65.36% and 34.64% in control group, respectively, thus, suggesting no statistically significant differences in the A (OR=0.75, 95% CI=0.54–1.03, p=0.08) and T (OR=1.32, 95% CI=0.96– 1.82, p=0.08) allele frequencies between the two groups.ConclusionWe conclude that the IFN-γ +874 TT genotype is associated with the increased risk of ischemic stroke.

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Genetic polymorphism of the interferon‐γ gene in cervical carcinogenesis

Cited by 30 publications

References 33 publications

Inhibitory Effect of Gamma Interferon on BK Virus Gene Expression and Replication

Inhibitory Effect of Gamma Interferon on BK Virus Gene Expression and Replication

Interferon gamma gene polymorphism as a marker of some allergic diseases (allergic skin diseases and allergic conjunctivitis) in a sample of Egyptian population

Interferon gamma (IFNγ) +874A/T gene polymorphism in South Indian ischemic stroke patients

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