Genetic polymorphism of the B subunit of human coagulation factor XIII in Japanese

Abstract

SummaryPolymorphism of the B subunit of human coagulation factor XIII was investigated in a total of 119 plasma samples from unrelated adult Japanese using agarose gel electrophoresis followed by immunofixation. Three common phenotypes were observed, which corresponded to the types 1, 1-3 and 3 reported by Board (1980) in Australians. The estimated allele frequencies of F13B*I and F13B*3 were 0.303 and 0.697, respectively. The observed numbers of the phenotypes were in good agreement with those expected on the basis of Hardy-Weinberg's law. These results are not inconsistent with the hypothesis that these phenotypes are controlled by a pair of autosomal, codominant alleles.