Gene frequency distribution of the B subunit of factor XIII (F XIIIB) in Minnesota Whites, Blacks and Amerindians

Miller, S.A.; Dykes, Dale D.; Polesky, Herbert F.

doi:10.1002/elps.1150060809

Cited by 13 publications

(2 citation statements)

References 10 publications

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“…The population studied is in genetic equilibrium assuming the HardyWeinberg hypothesis. When compared with those obtained in various other populations [1][2][3][4][5][6][9][10][11][12], our results in Libyans showed marked differences in the frequencies of the three common alleles FXIIIB*I, FXIIIB*2, FXIIIB*3 and the occurrence of a fourth common allele, FXIIIB*6. Further investigations in other Arab populations will clarify whether the FXIIIB*6 allele is specific for Libyans or a characteristic marker for Arabs.…”

Section: Immunoblottingmentioning

confidence: 71%

Genetic polymorphism of the B subunit of coagulation factor XIII in Libyans: Occurrence of a fourth common allele, FXIIIB*6

Sebetan

Azadeh

1989

Z Rechtsmed

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Summary. FXIIIB phenotypes were determined in neuraminidase-pretreated serum samples by using isoelectric focusing in ultrathin-layer polyacrylamide gels containing 1 M urea and subsequent immunoblotting. In a Libyan population sample from Tripoli, (n = 108) nine different phenotypes as products of four common alleles were recognized, with frequencies as follows: FXIIIB*I = 0.6574, FXIIIB*2 = 0.2454, FXIIIB*3 = 0.0741 and FXIIIB*6 = 0.0231. It is suggested that FXIIIB*6 is the fourth common allele of the FXIIIB system in this population.Key words: Coagulation factor XIIIB, Genetic polymorphism in LibyansAllele FXIIIB*6Zusammenfassung. Der genetisch determinierte Polymorphismus des FXIIIB wurde durch isoelektrische Fokussierung in ultradtinner Schicht eines Harnstoff-haltigen Polyacrylamidgels mit anschliegendem Immunoblott dargestellt. Die Serumproben wurden vor der Verimpfung mit Neuraminidase behandelt. Bei Libyern aus Tripoli (n = 108) wurden die neun h~iu-figen Phfinotypen FXIIIB 1-1, 2-1, 3-1, 2-2, 3-2, 3-3, 6-1, 6-3 und 6-6 beobachtet. Folgende Allelfrequenzen wurden ermittelt: FXIII*I = 0,6574, FXIIIB*2 = 0,2454, FXIIIB*3 = 0,0741 und FXIIIB*6 = 0,0231. Es wird vermutet, dab das Allel FXIIIB*6 das vierte, h~iufige (allgemeine) Allel in dieser Population darstellt.

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Section: Immunoblottingmentioning

confidence: 71%

Genetic polymorphism of the B subunit of coagulation factor XIII in Libyans: Occurrence of a fourth common allele, FXIIIB*6

Sebetan

Azadeh

1989

Z Rechtsmed

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“…F13B*2 is a good marker of African ancestry (56-63% among Blacks; lower than 15% elsewhere), and F13B*3 could be considered a Mongoloid marker, with a prevalence above 67% among people of Asian descent and lower among the others. Miller et al (1985) and Kamboh and Ferrel (1986) reported studies among three North and one Central American Indian populations, as well as in two Eskimo groups. The Mongoloid pattern outlined above is present among them, but none showed such a low prevalence of F13B*l and high of F13B*3 as the populations studied by us.…”

Section: Resultsmentioning

confidence: 98%

Linked loci in chromosome 1 (FXIIIB, HF, PEPC) and their variability in Brazilian Indians

Kömpf

Luckenbach

Krczal

et al. 1992

American J Hum Biol

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A total of 352 individuals living in seven localities of two Brazilian Indian groups (Macushi and Içana River Indians) were variously studied for coagulation factor XIIIB, human factor H, and a new polymorphism of peptidase C. No significant inter- or intra-tribal differences were found for the FXIIIB alleles, the frequencies varying around 95% for F13B*3 and 5% for F13B*1. Results for HF were heterogeneous, HF*A presenting a much higher frequency among the Macushi (32%) than among the Içana River Indians (9%). Intratribal differences were also found among both groups. Linkage disequilibrium exists between alleles of these two systems (0.03 ± 0.01). These are the first results for human factor H obtained among Amerindians. The data for PEPC were limited to the Içana River Indians. There is heterogeneity among the three localities sampled and evidence of moderate linkage disequilibrium between markers in this locus and in F13B (0.02 ± 0.01). © 1992 Wiley-Liss, Inc.

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Survey of seven plasma protein polymorphisms in the Amhara and Oromo populations of Ethiopia

Scacchi¹,

Rm²,

Rickards

et al. 1994

American J Hum Biol

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The Ethiopian population is very difficult to specify due to a very high degree of intermixing among different peoples. The two groups of the present study, the Amhara and Oromo, constitute 38% and 35% of the population, respectively. In order to investigate the genetic composition of the Amhara and Oromo, genetic polymorphisms of seven plasma proteins (F13A, F13B, ORM1, AHSG, C6, C7, and APOC2), already identified as useful anthropological markers, were studied. No statistically relevant differences were found between the two groups for all of the systems examined. ORM1 and F13A showed frequencies in the range observed in other populations of Caucasoid and Negroid origin. F13B, AHSG, and C6 displayed gene frequencies and a number of variant alleles that seem particular to these two groups. No variation was observed for C7 and APOC2. Correspondence and distance analyses were used to interpret and compare the gene frequencies of the Amhara and Oromo with those of other related populations. These methods locate Ethiopians in an intermediate position between African Blacks and a group of Caucasoid populations, confirming cultural and historical data. © 1994 Wiley-Liss, Inc.

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Gene frequency distribution of the B subunit of factor XIII (F XIIIB) in Minnesota Whites, Blacks and Amerindians

Cited by 13 publications

References 10 publications

Genetic polymorphism of the B subunit of coagulation factor XIII in Libyans: Occurrence of a fourth common allele, FXIIIB*6

Genetic polymorphism of the B subunit of coagulation factor XIII in Libyans: Occurrence of a fourth common allele, FXIIIB*6

Linked loci in chromosome 1 (FXIIIB, HF, PEPC) and their variability in Brazilian Indians

Survey of seven plasma protein polymorphisms in the Amhara and Oromo populations of Ethiopia

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