Genetic Polymorphism of MMP2 Gene and Susceptibility to Prostate Cancer

Ziaei, S A; Imani, Mahdieh; Samzadeh, Mohammad; Narouie, Behzad; Jamaldini, Seyed Hamid; Afshari, Mahdi; Safavi, Majid; Roshandel, Reza; Hasanzad, Mandana

doi:10.1016/j.arcmed.2015.08.004

Cited by 12 publications

(10 citation statements)

References 20 publications

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“…A total of eight papers with nine independent studies were included in this meta-analysis (Figure 1 ), of which six studies (Jacobs et al, 2008 ; dos Reis et al, 2009 ; Srivastava et al, 2012 ; Yaykasli et al, 2014 ; Adabi et al, 2015 ; Shajarehpoor Salavati et al, 2017 ) examined the association between MMP-2 -1306 C/T polymorphism and risk of prostate cancer and three studies (Albayrak et al, 2007 ; dos Reis et al, 2009 ; Tsuchiya et al, 2009 ) addressed the association between MMP-1 -1607 1G/2G polymorphism and risk of prostate cancer. The characteristics of all included studies in the meta-analysis are presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of all included studies in the meta-analysis are presented in Table 1 . For MMP-2 -1306 C/T polymorphism, two studies (Adabi et al, 2015 ; Shajarehpoor Salavati et al, 2017 ) were conducted in Iran, and only one study was respectively performed in USA (Jacobs et al, 2008 ), Brazil (dos Reis et al, 2009 ), Turkey (Yaykasli et al, 2014 ) and India (Srivastava et al, 2012 ). One study was involved in mixed populations and others were all related to Caucasians.…”

Section: Resultsmentioning

confidence: 99%

“…The expressions of MMPs are regulated mainly at the level of transcription, and polymorphisms in the promoter region of MMPs gene have been considered as transcriptional regulators (Yan and Boyd, 2007 ). Many studies have examined the associations between MMP-2 -1306 C/T (rs243865) and MMP-1 -1607 1G/2G (rs1799750) polymorphisms and risk of prostate cancer (Yaykasli et al, 2014 ; Adabi et al, 2015 ; Shajarehpoor Salavati et al, 2017 ). However, the conclusions are still inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Genetic Association between Matrix Metalloproteinases Gene Polymorphisms and Risk of Prostate Cancer: A Meta-Analysis

et al. 2017

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Background and Objective: Studies suggests that matrix metalloproteinase (MMP)-2-1306 C/T and MMP-1-1607 1G/2G polymorphisms affect the risk of prostate cancer. However, the conclusions remain controversial and no pooled evidence of this topic has been published. Therefore, we aimed to perform a meta-analysis to shed some light on the controversial conclusion pertaining to the associations of MMP-2-1306 C/T and MMP-1-1607 1G/2G polymorphisms with prostate cancer susceptibility.Methods: A thorough literature search was performed up to August, 2016 with the PubMed, EMBASE, CBM, CNKI, and Wanfang databases. Odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) were calculated to address the correlations between these polymorphisms and risk of prostate cancer.Results: The meta-analysis included six studies (1,921 patients and 1,988 controls) on MMP-2-1306 C/T polymorphism and three studies on MMP-1-1607 1G/2G polymorphism (438 patients and 394 controls), respectively. The overall results of meta-analysis showed that an elevated risk of the disease was implicated in MMP-2-1306 C/T polymorphism under two genetic models (CT vs. CC: OR = 1.78, 95% CI = 1.33–2.38; TT+CT vs. CC: OR = 1.62, 95% CI = 1.24–2.12) and no significant association was observed between MMP-1-1607 1G/2G polymorphism and the risk of prostate cancer. The subgroup analysis results of MMP-2-1306 C/T polymorphism were similar to the overall results. However, decreased risk of prostate cancer was observed in the Caucasians for MMP-1-1607 1G/2G polymorphism.Conclusions: Current meta-analysis indicates that MMP-2-1306 C/T polymorphism is associated with elevated risk of prostate cancer, but MMP-1-1607 1G/2G polymorphism may inhibit the occurrence of prostate cancer in Caucasians. Further studies are warranted to verify the conclusions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Genetic Association between Matrix Metalloproteinases Gene Polymorphisms and Risk of Prostate Cancer: A Meta-Analysis

et al. 2017

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“…Among the previous eligible studies, only four studies have been performed to explore the correlations between MMP2-1306C/T polymorphism with different Gleason group grades [ 17 – 18 , 20 – 21 ]. Patients were categorized into Gleason≥7 and Gleason<7.…”

Section: Resultsmentioning

confidence: 99%

Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects

et al. 2017

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Numerous investigations have addressed the correlation between MMP2-1306C/T polymorphism and prostate cancer (PCa) susceptibility. However, these conclusions were controversial. Thus, we conducted this current meta-analysis based on six studies from PubMed, Embase, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI) up to October 21st, 2016. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the correlations. Additionally, different subgroup analyses and publication bias tests were performed. Eventually, six previous investigations consisted of 1920 cases and 1986 controls were identified and involved in this meta-analysis. Consequently, our evidence indicates a certain association between MMP2-1306C/T polymorphism and PCa risk among overall population (T vs C: OR = 1.12, 95% CI = 1.00-1.24, P = 0.040; TT+CT vs CC: OR = 1.16, 95% CI = 1.02-1.32, P = 0.026; respectively), as well as the subgroups of Asian population (T vs C: OR=1.48, 95% CI=1.13-1.94, P=0.004; TT+CT vs CC: OR = 1.66, 95% CI = 1.21-2.28, P = 0.002; respectively) and PCR-RFLP genotyped method (T vs C: OR = 1.58, 95% CI = 1.19-2.10, P = 0.001; TT+CT vs CC: OR = 1.71, 95% CI = 1.23-2.38, P = 0.001; respectively). However, no association was detected in MMP2-1306C/T polymorphism with Gleason grading or pathological stage of PCa. Our study indicates MMP2-1306 C/T polymorphism might increase PCa risk, particularly for Asian population. However, future studies comprising large cohort size from multicenter are required to confirm our conclusions.

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“…Among the genes encoding this class of enzymes, MMP2 and MMP9 are analyzed for genetic variants associated with PCa risk, and also for disease aggressiveness, due to their functional significance in tumor invasiveness [139,[152][153][154][155][156]. Commonly analyzed genetic variant in MMP2 promoter is rs243865.…”

Section: Chronic Inflammation and Angiogenesismentioning

confidence: 99%

Genetic Association Studies on Prostate Cancer

Nikolic¹,

Savić‐Pavićević²,

Brajušković³

2016

Prostate Cancer - Leading-Edge Diagnostic Procedures and Treatments

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The modern research on molecular basis of prostate cancer (PCa) development includes studies aiming to identify potential genetic markers which could be used in diagnostics and/or monitoring of PCa. Genome-wide association studies (GWASs) have identified over 75 variants associated with PCa risk. One of the major PCarelated regions identified through GWASs is found to be a segment of 8q24. Other important PCa-susceptibility regions are 17q12, 17q24, 10q11, and 19q13. Candidategene based approach has also provided evidence of association between PCa risk and genetic variants located in functionally significant genes (both protein-coding and noncoding RNA genes) involved in normal prostatic cell growth, malignant transformation, or in the development of metastases. Nevertheless, the success of these studies is questionable, since numerous candidates for PCa-susceptibility variants were identified, but these results failed to replicate. The main aim of both types of genetic association studies on PCa is the identification of potential PCa genetic markers which could be used for constructing reliable algorithms for evaluating the risk for PCa development and/or PCa progression.

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Genetic Polymorphism of MMP2 Gene and Susceptibility to Prostate Cancer

Cited by 12 publications

References 20 publications

Genetic Association between Matrix Metalloproteinases Gene Polymorphisms and Risk of Prostate Cancer: A Meta-Analysis

Genetic Association between Matrix Metalloproteinases Gene Polymorphisms and Risk of Prostate Cancer: A Meta-Analysis

Association between MMP2-1306 C/T polymorphism and prostate cancer susceptibility: a meta-analysis based on 3906 subjects

Genetic Association Studies on Prostate Cancer

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