Genetic polymorphism of melatonin receptor 1A (<i>MTNR1</i>A) gene in Corriedale sheep of Kashmir, India

Ahmad, Tavsief; Ganai, T. A. S.; Magotra, Ankit; Sharma, Rahul; Aarif, Ovais

doi:10.5958/0976-0555.2015.00119.3

“…Notably, however, there is a pronounced drop in cycling activity during the spring and summer months in Egyptian sheep breeds (Aboul-Ela and Chemineau, 1990). The autumn and winter breeding seasons in local breeds had a significantly higher number of lambs born per ewe than the summer and spring breeding seasons (Ahmed, 2008). Therefore, it is important to plan lambing for unfavorable breeding seasons with the aim of continuous meat production throughout the year, especially in the months when lambing is less frequent.…”

Section: Discussionmentioning

confidence: 99%

Genetic polymorphism in melatonin receptor 1A and arylalkylamine N-acetyltransferase and its impact on seasonal reproduction in Egyptian sheep breeds

Fathy¹,

Gouda

²

,

Gafer³

et al. 2018

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This study was carried out to detect polymorphisms in the melatonin receptor 1A (MTNR1A) and arylalkylamine N-acetyltransferase (AA-NAT) genes and their association with reproductive traits. Blood samples of 126 animals from three Egyptian sheep breeds were collected. DNA was extracted and subjected to PCR restriction fragment length polymorphism (RFLP) analysis using the RsaI and SmaI enzymes. Two alleles (C and T) and three genotypes (CC, CT and TT) for MTNR1A and for AA-NAT (A and G; GG, GA and AA) were detected. The alleles C and A and the genotypes CT and GA showed the highest frequencies for the MTNR1A and AA-NAT genes, respectively. Association analysis of the MTNR1A single nucleotide polymorphism (SNP) with ewe reproductive traits revealed significant associations in the Ossimi and Rahmani breeds with age at first lambing, and the C allele seemed to be the favorable allele. The results for the AA-NAT SNP demonstrated significant correlations in Ossimi with age at first lambing and litter size and in Rahmani with lambing interval; the G allele seemed to be the desirable allele. In the first conception season, ewes carrying CT exhibited a significantly lower age of first lambing in the unfavorable season. Additionally, GG ewes exhibited a significantly lower age of first lambing in the early favorable season, followed by the unfavorable season. To the best of our knowledge, this is the first study of these associations in Egyptian sheep breeds. In conclusion, the polymorphisms revealed in this study could be used as genetic markers to improve reproductive efficiency during the unfavorable season, and the obtained desirable genotypes could be considered in new genetic selection schemes.

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“…Melatonin has an effect on reproduction, which is mediated through receptors that are found in the hypophyseal pars tuberalis. 18 Melatonin has an effect on the pars tuberalis, which in turn has an effect on the seasonal reproductive activity of females in a number of different mammalian species. 19 This includes the nuclei that are responsible for reproduction.…”

Section: Introductionmentioning

confidence: 99%

Association of melatonin receptor 1 A with litter size in sheep: A review

Abuzahra,

Wijayanti,

Effendi

et al. 2024

F1000Res

0

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Sheep are a valuable livestock species worldwide, providing meat, milk, and various dairy products. This article aims to review the latest literature on the melatonin receptor 1A (MTNR1A) gene as a potential candidate gene associated with reproductive traits, particularly the litter size trait in sheep, by searching various databases for available literature. Studies have shown that different parts of the MTNR1A gene play various roles in sheep. By identifying marker genes associated with reproductive traits in MTNR1A polymorphisms linked to the litter size trait, breeders can achieve a faster selection response in sheep breeding by recognizing the genomic region where these genes are located and understanding their physiological functions. Therefore, highlighting the literature on these functions and their association with reproductive traits may contribute to improving the genetic makeup during sheep breeding.

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Association study of melatonin receptor 1 A with litter size in sheep: A review

Abuzahra

¹

,

Wijayanti

²

,

Effendi

³

et al. 2023

F1000Res

0

View full text Add to dashboard Cite

Sheep are a valuable livestock species worldwide, providing meat, milk, and various dairy products. This article aims to review the latest literature on the melatonin receptor 1A (MTNR1A) gene as a potential candidate gene associated with reproductive traits, particularly the litter size trait in sheep, by searching various databases for available literature. Studies have shown that different parts of the MTNR1A gene play various roles in sheep. By identifying marker genes associated with reproductive traits in MTNR1A polymorphisms linked to the litter size trait, breeders can achieve a faster selection response in sheep breeding by recognizing the genomic region where these genes are located and understanding their physiological functions. Therefore, highlighting the literature on these functions and their association with reproductive traits may contribute to improving the genetic makeup during sheep breeding.

show abstract

Genetic polymorphism of melatonin receptor 1A (MTNR1A) gene in Corriedale sheep of Kashmir, India

Cited by 3 publications

References 11 publications

Genetic polymorphism in melatonin receptor 1A and arylalkylamine N-acetyltransferase and its impact on seasonal reproduction in Egyptian sheep breeds

Genetic polymorphism in melatonin receptor 1A and arylalkylamine N-acetyltransferase and its impact on seasonal reproduction in Egyptian sheep breeds

Association of melatonin receptor 1 A with litter size in sheep: A review

Association study of melatonin receptor 1 A with litter size in sheep: A review

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