Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung cancer

Salagovic, J; Kalina, I; Stubna, J; Habalová, Viera; Biroš, Erik

doi:10.1016/s0169-5002(98)90112-x

Cited by 24 publications

(33 citation statements)

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“…Our findings agree with previous studies (Abdel-Rahman et al 1998;Salagovic et al 1998) that showed a significantly increased risk of bladder cancer for GSTT1-null genotype in Egypt and in Slovakia. Since GSTT1 is strongly involved in the metabolism of lower molecular weight electrophilic molecules (Guengerich et al 1995), the decreased frequency of a genotype encoding active GSTT1 might have a role in carcinogenesis of bladder (Salagovic et al 1998).…”

Section: Discussionsupporting

confidence: 93%

“…In contrast to GSTM1, the potential role of GSTT1 genotype in individuals' susceptibility to bladder cancer has been reported with inconsistent results. A few studies exhibited a non-significant decreased risk of bladder cancer with GSTT1-null genotype (Brockmoller et al 1996;Katoh et al 1998); however, some other studies exhibited increased risk of bladder cancer with GSTT1-null genotype (Salagovic et al 1998;Lee et al 1999). Inconsistent results have also emerged from recent studies exploring the combined effect of GSTM1 and GSTT1 genotype in the development of this malignancy (Salagovic et al 1998;Georgiou et al 2000).…”

Section: Introductionmentioning

confidence: 99%

“…A few studies exhibited a non-significant decreased risk of bladder cancer with GSTT1-null genotype (Brockmoller et al 1996;Katoh et al 1998); however, some other studies exhibited increased risk of bladder cancer with GSTT1-null genotype (Salagovic et al 1998;Lee et al 1999). Inconsistent results have also emerged from recent studies exploring the combined effect of GSTM1 and GSTT1 genotype in the development of this malignancy (Salagovic et al 1998;Georgiou et al 2000). Data also suggest that null genotypes of GSTM1 and GSTT1, both individually and in combination, are low-penetrance genetic risk factors for oral cancer in tobacco chewers of Indian ethnicity (Nair et al 1999;Sreelekha et al 2001;Buch et al 2002).…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism of GSTM1 and GSTT1 genes in bladder cancer: a study from North India

et al. 2004

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The present study was conducted (1) to examine whether the GSTT1- and GSTM1-null genotypes are risk factors for bladder cancer, and (2) to study possible association of tobacco usage and age strata with genotype of these patients. This case control study was undertaken over a period of 19 months and included 106 bladder cancer patients and 182 controls; both patients and controls originated from northern part of India. The GSTT1 and GSTM1 genotypes were identified by multiplex PCR in peripheral blood DNA samples. Genotype frequencies among patients and controls were assessed and the association of the genotypes with smoking habits and gender of the patients were statistically determined by the chi(2) test. Frequencies of null genotypes in GSTT1 and GSTM1, were 16% (29/182) and 30% (54/182), respectively, in control individuals. The frequencies of GSTT1- and GSTM1-null genotypes in bladder cancer patients were 26% (28/106) and 40% (42/106), respectively. In conclusion, our study demonstrated that the null genotypes of GSTT1 and GSTM1 were substantially at higher risk for bladder carcinoma compared to the normal healthy controls. The GSTT1- and GSTM1-null genotypes did not show significant association with tobacco usage in bladder cancer patients. However, the null genotypes were statistically significant in female relative to male bladder cancer patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polymorphism of GSTM1 and GSTT1 genes in bladder cancer: a study from North India

et al. 2004

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“…4 The (GSTM1) and (GSTT1) members of the GST multigene family, which are polymorphic in humans, are involved in detoxifying mutagenic electrophilic compounds, and an increased frequency of these GST gene deletions has been associated with several malignancies. [5][6][7] The present study investigated whether homozygous gene deletions of GSTM1 and GSTT1 increase the incidence of aplastic anemia and explored the relationship between the GST genotype and the chromosomal abnormalities in aplastic anemia patients to clarify the multistep pathogenesis of aplastic anemia based on this possible genetic predisposition.…”

Section: Introductionmentioning

confidence: 99%

Increased frequencies of glutathione S-transferase(GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia

Lee

Kim

Woo

et al. 2001

Blood

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Patients with reduced ability to metabolize environmental carcinogens or toxins may be at risk of developing aplastic anemia. Glutathione S-transferase (GST) has been implicated in detoxifying mutagenic electrophilic compounds. This study asked whether the homozygous gene deletions of GSTM1 and GSTT1 affect the likelihood of developing aplastic anemia. The incidence of GSTM1 and GSTT1 gene deletions was significantly higher for aplastic anemia patients (odds ratio [OR]: 3.1, P ‫؍‬ .01 and OR: 3.1, P ‫؍‬ .004, respectively) than for healthy controls. Among the aplastic anemia patients, 17.5% (10:57) had chromosomal abnormalities at the time of diagnosis, and all aplastic anemia patients with chromosomal abnormalities showed GSTT1 gene deletions (P ‫؍‬ .048). Individuals with GSTM1 and GSTT1 gene deletions may have greater susceptibility to aplastic anemia. It is possible that genetic instability or chromosomal damage due to abnormal detoxification of environmental toxins might have worked as an important pathophysiologic mechanism of aplastic anemia for patients with GSTT1 gene deletions. (Blood. 2001;98:3483-3485)

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“…[13], [18] Several Caucasian studies were previously conducted to assess the role of GSTT1 in lung cancer susceptibility with the case-control approach. [10], [11], [19][20][21][22] No significant associations of GSTT1 with lung cancer risk could be established, and two of the studies found that the GSTT1 null genotype did not elevate the risk with either lung adenocancer or squamous cell carcinoma. [19], [20] Another study in Chinese found that the GSTT1 genotype was not related to lung cancer.…”

Section: Discussionmentioning

confidence: 99%

The frequency of GSTT1 null genotype in Turkish population and lung cancer risk

Demir¹,

Altın²,

Demir³

et al. 2005

Indian J Hum Genet

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BACKGROUND:Previous studies have suggested that Glutathione S-transferase (GST) genotypes may play a role in determining susceptibility to lung cancer, though the data are often conflicting. In different ethnic groups variations in null allele frequency has been observed. AIMS: We aimed to evaluate whether genetic polymorphisms of Glutathione S-transferase theta (GSTT1) influence individual susceptibility to lung cancer in Turkish population. We tried to clarify the frequencies of GSTM1 gene polymorphisms in a Turkish population. METHODS: DNA samples, extracted from the whole blood were amplified using polymerase chain reaction (PCR) method in all of the 68 cases, composed of 31 previously diagnosed lung cancer and 37 healthy controls. RESULTS: The prevalence of GSTT1 null genotype in the lung cancer patients was 29%, compared to 11% in control group. GSTT1 null genotype was found to be higher in cancer group compared to the control group, although it was not statistically significant (OR = 3.37, 95% CI = 0.92-12.32, P = 0.06). There was also no significant relation in GSTT1 genotypes among histopathology types of lung cancers. The frequency of GSTT1 was found to be 25.4% (n = 952) when the studies of Turkish population were reviewed. CONCLUSION: It can be concluded that carrying the GSTT1 null genotype may be accepted as a weak risk factor for the susceptibility to lung cancer.Key words: Genetic polymorphism; GSTT1 and molecular epidemiology; lung cancer. Lung cancer is the most common malignancy and the leading cause of cancer death in men world wide and also the second most lethal cancer in women after breast cancer.[1], [2] Active and passive smoking, various occupational exposures, and carcinogens in heavily

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Genetic polymorphism of glutathione S-transferases M1 and T1 as a risk factor in lung cancer

Cited by 24 publications

References 0 publications

Polymorphism of GSTM1 and GSTT1 genes in bladder cancer: a study from North India

Polymorphism of GSTM1 and GSTT1 genes in bladder cancer: a study from North India

Increased frequencies of glutathione S-transferase(GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia

The frequency of GSTT1 null genotype in Turkish population and lung cancer risk

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