Genetic polymorphism of Cytochrome-P450-2C9 (CYP2C9) in Indian populations

Abstract

Cytochrome-P450-2C9 (CYP2C9) metabolizes wide range of drugs and highly express in human liver. Various mutations of CYP2C9 (R144C, I359L etc.), associated with drugresponse, are highly diverse. We aimed to investigate the genetic diversity of CYP2C9 in Indian-subcontinent, using 1278 subjects from 36 populations. High frequency of CYP2C9*3

Association of HLA-B*51:01, HLA-B*55:01, CYP2C9*3, and Phenytoin-Induced Cutaneous Adverse Drug Reactions in the South Indian Tamil Population

“…A total of 52 PHT-CADRs patients (31 MPE, 7 SJS/TEN, 8 DRESS, and 5 FDE) and 100 PHT-tolerant control patients with ages ranging from 6 to 72 were included in the pooled analysis. There were 22/30 and 41/59 females and males in their case and tolerant groups, respectively [ 20 ].…”

“…In Asian populations, HLA B*51:01 has been related to PHT-induced CADRs, particularly with PHT-SCARs [ 40 , 41 ].A recent multicenter East Asian study that investigated the genetic predictors of PHT-hypersensitivity reported that concurrent testing of HLA B* 13:01/HLA B* 15:02/HLA B*51:01 and CYP2C9*3 would help in identifying individuals at risk of developing PHT-CADRs [ 42 ]. In India, one of the North Indian studies reported HLA B*57:01 (OR = 11.00, 95% CI: 1.41–85.81, p = 0.05) and HLA B*51:01 (OR = 6.90, 95% CI: 1.38–34.29, p = 0.007) as risk factors for CBZ-SJS and PHT-DRESS, respectively [ 20 ]. In the current study, the HLA B*51:01 allele was found to be strongly associated with PHT-SCARs, especially DRESS, and the pooled data analysis corroborated this relationship with both SCARs and overall CADRs.…”

“…We used pooled data analysis for the HLA B*51:01 to boost the study’s power. The HLA B*51:01 case and tolerant control data were obtained from one of the North Indian studies that reported the relationship between HLA alleles and AED-induced CADRs [ 20 ].…”

“…For example, the frequency of HLA B*15:02 is lower (0%) among West Coast Parsi and higher (6%) among Pawra in the Khandesh region [ 18 , 19 ]. Similarly, the frequency of CYP2C9*3 varies by location in India: a higher frequency (7–9%) is seen in the Dravidian population, whereas the prevalence is relatively low (0–2%) in the North Indian population [ 20 ].…”

A review on advances in synthetic methodology and biological profile of spirothiazolidin‐4‐ones

“…The reaction of cyclohexanone 44 with 126 and 129 in CH 3 OH/CH 3 COOH afforded 127 and 130. Several 3-(Nsubstitutedarylthiocarbanilido)-spiro(cyclohexane)-1, 2-(4-thiazolidinone) 128 and 3-arylamidospiro(cyclohexane)-1 0 2-(4-thiazolidinone) 131 have been synthesized by reaction of 1-aryl-4-cyclohexane thiosemicarbazone 127 and 1-aroylcyclohexane-hydrazone 130 with thiogylcolic acid respectively reported by Nizamuddin and Singh (Scheme 29) [60]. Some of the obtained products were tested for their molluscidal activity against Lymnaea acuminate.…”