Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer

Sreelekha, T.T.; Ramadas, K; Pandey, Manoj; Thomas, Gigi; Nalinakumari, K.R.; Pillai, M.R.A.

doi:10.1016/s1368-8375(01)00028-8

Cited by 135 publications

(91 citation statements)

References 20 publications

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“…In the present study conducted on a south Indian population, no significant association was observed between risk of Oral SCC and GSTM1 homozygous null genotype. The observed lack of a significant association between the GSTM1 null genotype and susceptibility to oral cancer in the present study is similar to that observed in previous studies 23,24 . Vaury etal hypothesized that the CYP1A1 genoype and GSTM1 null interactions result in a greater-than-additive risk for DNA damage and cancer 25 .…”

Section: Discussionsupporting

confidence: 92%

Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer

Shukla¹,

Kale²,

Hallikerimath³

et al. 2012

BIOMED PAP

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Aims. Polymorphisms in the genes that code for metabolic enzymes involved in either the activation (Phase I) or detoxication (Phase II) of chemical carcinogens in tobacco, may alter expression or function of carcinogenic compounds and hence alter risk of oral cancer. The present study investigates whether polymorphisms at CYP1A1 and GSTM1 gene loci act as risk factors for oral precancerous lesions and cancer. Methods. For the present study, histopathologically confirmed cases of 90 oral precancerous lesions, 150 oral squamous cell carcinoma (SCC) and 150 control subjects were selected. Polymerase chain reaction and restriction fragment length polymorphism were performed using DNA from blood samples to determine the polymorphic genotypes at CYP1A1 and GSTM1 loci. Results. CYP1A1 C (m2/m2) genotype conferred a 12.0 fold-increased risk (OR=12.0; 95% CI, 2.40-60.05) to oral SCC. GSTM1 null showed no significant association but the frequency was higher in oral SCC cases. Patients with genotype C and/or GSTM1 deficiency developed carcinoma after less tobacco consumption than those of other genotypes though the difference was not statistically significant. The frequency of the combined genotypes C and GSTM1 null was found to be 14% among oral SCC patients. On comparing the susceptibility of intraoral sites it was found that in the majority of cases (64%) in the study groups they were the buccal mucosa. Conclusion. Hence it was concluded that metabolic enzymes reported in the present study: CYP1A1 significantly alter oral cancer risk. GSTM1 null and CYP1A1 C (m2m2) show a predisposition to premalignant lesions and cancer of the buccal mucosa than other sites.

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Section: Discussionsupporting

confidence: 92%

Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer

Shukla¹,

Kale²,

Hallikerimath³

et al. 2012

BIOMED PAP

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“…Number of female smokers was very less, so it was not possible to compare the results between both the genders. No significant differences were observed between smokers and non-smokers, alcoholic and non-alcoholic individuals, tobacco chewers and non-chewers, carrying homozygous GSTM1/GSTT1/GSTM1T1 null genotype (p>0.05) ( Anantharaman, 2007;Buch et al, 2002;Nair et al, 1999 South Indians c 1744 485 (27.8)** 242 (13.9) 136 (7.8) Naveen et al, 2004;Samson, 2007;Shehnaz et al, 2011;Sreelekha et al, 2001;Suneetha, 2011;Vettriselvi et al, 2006;Vijayalakshmi et al, 2005 East Indians d 67 18(27.0) 9 (13.0) Sikdar et al, 2005 Central Indians e 282 99 (35.1) 37 (13.0) Devi et al, 2008 North Nair et al, 1999;Singh et al, 2009 Blacks b 3008 960 (31.9) 744 (24.9)* 298 (9.9)* Adams et al, 2003;Benzamin et al, 2011;Coutinho et al, 2010;Dandara et al, 2002;Lavender et al, 2009;Masimirembwa et al, 1998;Millikan et al, 2000;Rossini et al, 2002 Caucasians c 2674 1064/2232 (47.7)* 448/2674 (16.7) 31 (9.3) Amer et al, 2011;Baranova et al, 1997;Chen et al, 1996;D'Alo et al, 2004;Gsur et al, 2001;Kargas et al, 2003;Millikan et al, 2000;Mitrunen et al, 2001;Steinhoff et al, 2000;Welfare et al, 1999 Asians 1). The frequency distribution of GSTM1 and GSTT1 alleles were compared between different states of India and other populations all over the world (Table 2 and 3).…”

Section: Resultsmentioning

confidence: 99%

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Sharma¹,

Pandey²,

Sardana³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics, including an array of environmental carcinogens, pollutants, and drugs. Genetic polymorphisms in these genes may lead to interindividual variation in susceptibility to various diseases. In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi. The frequency of individuals with GSTM1 and GSTT1 null genotypes were 168 (33.6%) and 62 (12.4%) respectively, and 54(10.8%) were having homozygous null genotype for both the genes GSTM1 and GSTT1simultaneously. The studied population was compared with reported frequencies from other neighbouring state populations, as well as with those from other ethnic groups; Europeans, Blacks, and Asians. The prevalence of homozygous null GSTM1 genotype is significantly higher in Caucasians and Asians as compared to Indian population. The frequency of GSTT1 homozygous null genotypes is also significantly higher in blacks and Asians. We believe that due to large number of individuals in this study, our results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi. It would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

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“…[13][14][15][16][17][18][19][20][21][22] Two genes in particular -GSTT1 and GSTM1 -that code phase II enzymes belonging to the glutathione S-transferases (GSTs) family seem relevant for susceptibility to head and neck squamous cell carcinoma; they detoxify carcinogenic tobacco smoke reactive metabolites. [11][12]13,15,18,20,23 The GSTM1 gene is polymorphic in humans, including a null-activity allele (GSTM1-) due to a major genic deletion, and two functional alleles (GSTM1A and GSTM1B). The GSTT1 gene is also polymorphic in humans, and may have a deletion null genotype.…”

Section: Introductionmentioning

confidence: 99%

Polimorfismos GSTT1 e GSTM1 em indivíduos tabagistas com carcinoma espinocelular de cabeça e pescoço

Biselli

Leal

Ruiz

et al. 2006

Rev. Bras. Otorrinolaringol.

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Gene variability related to carcinogen activation and detoxification may interfere with susceptibility to head and neck cancer. Aim: To investigate the relation between GSTT1 and GSTM1 null polymorphisms and the risk of head and neck squamous cell carcinoma in cigarette smokers. Material and Method: A case-control study conducted at the Sao Jose do Rio Preto Medical School, Brazil. GSTM1 and GSTT1 null genotype frequencies were evaluated by multiplex PCR in 45 cigarette smokers with head and neck squamous cell carcinomas and 45 cigarette smokers without this disease. Results: The oral cavity was the most prevalent tumor site for squamous cell carcinoma. The GSTT1 null genotype was found in 33.3% of the Experimental Group and 23.3% of the Control Group (p= 0.311). Experimental and Control Groups had GSTM1 null genotype frequencies of 35% and 48.3% (p=0.582). No association between alcohol consumption and GSTT1 and GSTMI null genotypes was found in these groups (p-values>0.05). There were more men, and alcohol consumption was prevalent in both groups. Conclusion: In this study we were unable to show a correlation between GSTM1 and GSTT1 genotypes and the development of head and neck squamous cell carcinomas in cigarette smokers.

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Genetic polymorphism of CYP1A1, GSTM1 and GSTT1 genes in Indian oral cancer

Cited by 135 publications

References 20 publications

Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer

Genetic polymorphism of drug metabolizing enzymes (GSTM1 and CYP1A1) as risk factors for oral premalignant lesions and oral cancer

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Polimorfismos GSTT1 e GSTM1 em indivíduos tabagistas com carcinoma espinocelular de cabeça e pescoço

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