Genetic polymorphism of apolipoprotein A-IV in five different regions of Europe. Relations to plasma lipoproteins and to history of myocardial infarction: the EARS study

Ehnholm, Christian; Knijff, Peter de; Havekes, L.M.; Rosseneu, Maryvonne; Menzel, H J; Tiret, Laurence; Tenkanen, H

doi:10.1016/0021-9150(94)90024-8

Cited by 41 publications

(23 citation statements)

References 45 publications

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“…The effects of exercise on plasma apoA-IV have not been studied in detail, but it appears that moderate exercise has no pronounced influence on apoA-IV levels. 27 Thus, the change of physical activity during the dietary camp is unlikely to explain the dramatic drop of plasma apoA-IV. The reasons for the marked decrease of apoA-IV during weight reduction therefore remain to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

et al. 2004

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Section: Discussionmentioning

confidence: 99%

Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

et al. 2004

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“…These studies have demonstrated that apoE allele frequency varies across race/ethnicity as well as within race/ ethnic groups; the e4 allele frequency varies among Europeans, with a high frequency among Northern Europeans (12,(14)(15)(16), whereas certain Asian (17)(18)(19)(20)(21) and American Indian (22,23) groups appear to have reduced frequencies of the e2 and e4 alleles. Furthermore, the e4 allele frequency is considerably higher among African Americans (24)(25)(26)(27).…”

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confidence: 99%

Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol

Anuurad

Rubin

et al. 2006

Journal of Lipid Research

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We studied the relationship of apolipoprotein E (apoE) isoforms and coronary artery disease (CAD) in 224 African Americans and 326 Caucasians undergoing diagnostic coronary angiography. The presence of CAD was defined as .50% stenosis in at least one artery. ApoE allele frequencies were 0.12, 0.62, and 0.26 for e2, e3, and e4, respectively, in African Americans and 0.08, 0.78, and 0.14 for e2, e3, and e4, respectively, in Caucasians. Among African Americans, CAD was present in 9 of 34 e2 carriers (26%), significantly smaller (P , 0.05) in proportion compared with 39 of 82 e3 carriers and 43 of 92 e4 carriers (48% and 47%, respectively), suggesting a protective effect of the e2 allele. No such difference was seen in Caucasians. In African Americans but not Caucasians, LDL cholesterol was lower in e2 carriers than in e3 and e4 carriers (106 vs. 127 and 134 mg/dl, respectively; P , 0.005). After adjusting for lipid levels, the association between apoE2 and CAD was no longer significant. Thus, the protective effect of apoE2 seen in African Americans could be explained by a favorable lipid profile in e2 carriers, whereas in Caucasians, the absence of such a protective effect could be attributable to the lack of effect of apoE2 on the lipid

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“…The frequency of the His isoform (APOA4-2 allele) 6 varies worldwide, from being completely absent in Japan and among American Indians to 0.11 in Iceland. [7][8][9][10][11][12][13] Some population studies have shown that the APOA4-2 allele is associated with a less atherogenic profile, 9 although other studies have not confirmed this observation. 14,15 In dietary intervention trials, carriers of this allele have been shown to be less responsive to dietary changes, in terms of LDL cholesterol (LDL-C), than carriers of the APOA4-1/1 (Gln/Gln) alleles.…”

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confidence: 99%

Genetic Variation at the ApoA-IV Gene Locus and Response to Diet in Familial Hypercholesterolemia

Carmena-Ramón¹,

Ascaso²,

Real³

et al. 1998

ATVB

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Abstract-Plasma lipid response to dietary fat and cholesterol is, in part, genetically controlled. The apolipoprotein A-IV (apoA-IV protein; APOA4, gene) has been shown to influence the response to dietary changes in normolipidemic individuals. The response to diet in subjects with familial hypercholesterolemia (FH) is also variable, and no studies are available on the influence of APOA4 mutations on dietary response in these subjects. We studied the effect of 2 common apoA-IV genetic variants (Gln 360 3 His and Thr 347 3 Ser) on the lipid response to the National Cholesterol Education Program type I (NCEP-I) diet in 67 FH heterozygotes (43 women and 24 men). Subjects were studied at baseline (after consuming for 1 month a diet with 35% fat [10% saturated] and 300 mg/d cholesterol) and after 3 months of consuming a low-fat diet. No sex-related differences were found, and results were combined for men and women. The APOA4-360 mutation was assessed in 67 subjects, 51 with genotype 1/1 and 16 with genotype 1/2. The APOA4-2 allele was associated with marginally significantly lower (Pϭ0.049) low density lipoprotein (LDL) cholesterol levels and significantly lower (Pϭ0.027) apoB levels independent of diet effects. After consuming an NCEP-I diet, carriers of the APOA4-2 allele showed a significantly lower reduction in apoB concentration (6.2%) than 1/1 subjects (14.1%; Pϭ0.036); however, no significant differences in response were noted for LDL cholesterol. The APOA4-347 mutation was assessed in 63 individuals, 44 with the A/A allele and 19 with the A/T and T/T alleles. No significant differences were observed in baseline or post-NCEP-I diet values for these 2 groups in total, LDL, and high density lipoprotein cholesterol and plasma apoB levels. After dietary intervention, A/A individuals showed significant reductions in plasma triglyceride and very low density lipoprotein cholesterol levels; no changes were found in carriers of the T allele. Haplotype analysis suggested that in these FH subjects, the APOA4-360-2 allele was associated with lower plasma lipid levels during the NCEP-I diet period, whereas no significant effects were observed for the APOA4-347-T allele.

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Genetic polymorphism of apolipoprotein A-IV in five different regions of Europe. Relations to plasma lipoproteins and to history of myocardial infarction: the EARS study

Cited by 41 publications

References 45 publications

Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

Protective effect of apolipoprotein E2 on coronary artery disease in African Americans is mediated through lipoprotein cholesterol

Genetic Variation at the ApoA-IV Gene Locus and Response to Diet in Familial Hypercholesterolemia

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