Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

Lingenhel, Arno; Eder, Claudia; Zwiauer, Karl; Stangl, Herbert; Kronenberg, Florian; Patsch, Wolfgang; Strobl, Wolfgang

doi:10.1038/sj.ijo.0802789

Cited by 20 publications

(20 citation statements)

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“…The decrease of plasma C was mainly due to not only a reduction of LDL(C) ( Table 2) but also a slight decrease of HDL(C). As in our earlier studies (8,24), plasma leptin decreased much more than SDS-BMI (Table 1), confirming reports that plasma leptin is lower during active weight loss than during maintenance of reduced body weight (25).…”

Section: Resultssupporting

confidence: 76%

Effect of Obesity on Plasma Clusterin: A Proposed Modulator of Leptin Action

et al. 2011

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Clusterin, a protein constituent of HDL, was recently shown to bind plasma leptin in vitro and has been proposed to modulate leptin activity. To gain insight into a possible role for plasma clusterin in human obesity, we measured plasma clusterin, leptin, soluble leptin receptor (sObR), and lipoproteins in 70 obese adolescents (12.4 Ϯ 1.6 y; BMI-SD score (SDS-BMI) 2.35 Ϯ 0.47) before and after 3 wk of weight reduction in a dietary camp and in 44 normal weight controls. Binding of plasma leptin to HDL or clusterin was studied using ultracentrifugation and immunoaffinity chromatography. During weight reduction, clusterin decreased from 14.6 Ϯ 4.1 to 10.3 Ϯ 2.9 mg/dL, p Ͻ 0.001) in obese adolescents, whereas sObR increased. However, baseline plasma clusterin in obese adolescents did not differ from controls. Clusterin did not correlate with SDS-BMI, weight loss, leptin, or lipoproteins. Only ϳ1% of plasma leptin was associated with clusterin/apoA-I complexes or with HDL. Our results do not support a role for plasma clusterin as an important leptin-binding protein or modulator of leptin action. The decrease of plasma clusterin during weight reduction may be an effect of the hypocaloric diet rather than being directly linked to weight loss. (Pediatr Res 69: 237-242, 2011)

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Section: Resultssupporting

confidence: 76%

Effect of Obesity on Plasma Clusterin: A Proposed Modulator of Leptin Action

et al. 2011

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“…ApoA-IV exerts a strong anti-atherogenic effect [17] and has also been suggested to act as a satiety factor. Plasma apoA-IV is elevated in human type 2 diabetes and obesity and decreases during weight reduction [18,19].…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats

Dorfmeister

Brandlhofer

Schaap³

et al. 2006

Diabetologia

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“…Several studies demonstrated effects of weight reduction on cardiovascular risk factors in children. 8,38 However, this is the first study to demonstrate a beneficial effect of short-term weight-reduction on Lp(a) levels in children, and to show that this effect depends on the CNV in the apo(a) gene. CNVs represent the most prevalent type of structural variation in the human genome and significantly contribute to genetic heterogeneity.…”

Section: Discussionmentioning

confidence: 79%

“…8 Mean daily energy intake during the 3-week period was 1600 kcal at the start of the camp and decreased to 1200 kcal by the end of the camp. No electrolyte or vitamin supplementation was provided.…”

Section: Dietary Camp Programmentioning

confidence: 97%

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Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

et al. 2009

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Background: Lipoprotein(a) [Lp(a)] is considered an independent risk factor for cardiovascular disease. Its concentration is mainly determined by the kringle-IV repeat copy number variation (CNV) at the apolipoprotein(a) [apo(a)] locus. Objective: We aimed to investigate the immediate effect of weight reduction on plasma Lp(a) levels and its dependency on the apo(a) CNV in obese children. Design: We performed a prospective longitudinal intervention study of a low-fat hypocaloric diet conducted in a 3-week dietary camp for obese children. In all, 140 obese participants (54 boys and 86 girls) with a mean age of 12.5 ± 1.6 years and a mean relative body mass index (BMI) before treatment of 165.6±24.7% were included. Body weight and plasma levels of Lp(a), lipids, apolipoproteins A-I and B, insulin, and C-reactive protein were determined before the onset and after the end of the intervention. In addition, the number of apo(a) kringle-IV repeats were determined using sodium dodecyl sulfate agarose gel electrophoresis. Results: The mean loss of body weight was 5.0 ± 1.3 kg (À6.6%), resulting in a mean decrease of the relative BMI of 6.6%. Blood chemistry revealed significant changes in all parameters, especially in Lp(a), with a decrease from 24.4 ± 30.6 to 17.9 ± 22.6 mg per 100 ml or À19% (Po0.001). The decrease of Lp(a) levels was higher in the group with low compared with high molecular weight apo(a) phenotypes (À23.9 vs À16.6%). Conclusions: Weight reduction in obese children is associated with significant changes in Lp(a) levels, especially in subjects with high pre-treatment Lp(a) concentrations. This effect is markedly influenced by the molecular phenotype at the copy-number variable apo(a) locus.

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Decrease of plasma apolipoprotein A-IV during weight reduction in obese adolescents on a low fat diet

Cited by 20 publications

References 35 publications

Effect of Obesity on Plasma Clusterin: A Proposed Modulator of Leptin Action

Effect of Obesity on Plasma Clusterin: A Proposed Modulator of Leptin Action

Apolipoprotein AV does not contribute to hypertriglyceridaemia or triglyceride lowering by dietary fish oil and rosiglitazone in obese Zucker rats

Decrease of Lp(a) during weight reduction in obese children is modified by the apo(a) kringle-IV copy number variation

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