Genetic Parameters of Milk β-Hydroxybutyric Acid and Acetone and Their Genetic Association with Milk Production Traits of Holstein Cattle

Lee, SeokHyun; Cho, KwangHyun; Park, MiNa; Choi, Tae-Jeong; Kim, Si-Dong; Do, Chang-Hee

doi:10.5713/ajas.16.0310

Cited by 17 publications

(20 citation statements)

References 24 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a literature review, Pryce et al (2016) reported low heritability estimates for clinical ketosis ranging from 0.01 to 0.16. In previous studies, most of the estimates for milk and serum BHB traits are low or moderate but higher than estimates for clinical ketosis (van der Drift et al, 2012;Koeck et al, 2014;Koeck et al, 2016;Miglior et al, 2014;Lee et al, 2016). For example, in a study of Lee et al (2016) the heritability for milk BHB 30 days postpartum was 0.10 (the average heritability for the first parity was 0.08).…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Genetic parameters for endocrine and traditional fertility traits, hyperketonemia and milk yield in dairy cattle

Häggman

Christensen²,

Mäntysaari

et al. 2019

animal

View full text Add to dashboard Cite

High-yielding cows may suffer from negative energy balance during early lactation, which can lead to ketosis and delayed ability of returning to cyclicity after calving. Fast recovery after calving is essential when breeding for improved fertility. Traditionally used fertility traits, such as the interval from calving to first insemination (CFI), have low heritabilities and are highly influenced by management decisions. Herd Navigator™ management program samples and analyses milk progesterone and β-hydroxybutyrate (BHB) automatically during milking. In this study, the genetic parameters of endocrine fertility traits (measured from milk progesterone) and hyperketonemia (measured from milk BHB) in early lactation were evaluated and compared with traditional fertility traits (CFI, interval from calving to the last insemination and interval from first to last insemination) and the milk yield in red dairy cattle herds in Finland. Data included observations from 14 farms from 2014 to 2017. Data were analyzed with linear animal models using DMU software and analyses were done for first parity cows. Heritability estimates for traditional fertility traits were low and varied between 0.03 and 0.07. Estimated heritabilities for endocrine fertility traits (interval from calving to the first heat (CFH) and commencement of luteal activity (C-LA)) were higher than for traditional fertility traits (0.19 to 0.33). Five slightly different hyperketonemia traits divided into two or three classes were studied. Linear model heritability estimates for hyperketonemia traits were low, however, when the threshold model was used for binary traits the estimates became slightly higher (0.07 to 0.15). Genetic correlation between CFH and C-LA for first parity cows was high (0.97) as expected since traits are quite similar. Moderate genetic correlations (0.47 to 0.52) were found between the endocrine fertility traits and early lactation milk yield. Results suggest that the data on endocrine fertility traits measured by automatic systems is a promising tool for improving fertility, specifically when more data is available. For hyperketonemia traits, dividing values into three classes instead of two seemed to work better. Based on the current study and previous studies, where higher heritabilities have been found for milk BHB traits than for clinical ketosis, milk BHB traits are a promising indicator trait for resistance to ketosis and should be studied more. It is important that this kind of data from automatic devices is made available to recording and breeding organizations in the future.

show abstract

Section: Discussionmentioning

confidence: 94%

“…Koeck et al, 2016), BHB concentration measured at first or some specific test day (e.g. van der Drift et al, 2012;Koeck et al, 2014;Lee et al, 2016) and classification based on different BHB thresholds (e.g. Miglior et al, 2014) Oetzl, 2007).…”

Section: Discussionmentioning

confidence: 99%

Genetic parameters for endocrine and traditional fertility traits, hyperketonemia and milk yield in dairy cattle

Häggman

Christensen²,

Mäntysaari

et al. 2019

animal

View full text Add to dashboard Cite

show abstract

“…β-hydroxybutyrate and dairy cow performance routine milk recording is not feasible because it is too expensive and time consuming, whereas MIRS allows to collect data at population level cheaply and provide routine reports to farmers for monitoring their herd. Currently, the accuracy of the developed prediction equations for BHB concentration in milk is not high enough to quantify the exact content but it has proved to be useful for screening purposes to detect cows with elevated BHB concentrations in milk (Grelet et al, 2016;Lee et al, 2016;Santschi et al, 2016). Moreover, predicted milk acetone and BHB have been used to develop models for the prediction of blood BHB from test-day milk and performance traits (Chandler et al, 2018), and the use of MIRS milk spectra has been proposed to directly predict blood BHB concentration (Belay et al, 2017a and2017b).…”

Section: Methods and Thresholds Used To Define Hyperketonemiamentioning

confidence: 99%

“…Santschi et al (2016). On the other hand, Lee et al (2016) considered cows as affected by SCK with milk BHB concentration between 0.01 and 0.20 mmol/l, and affected by CK with milk BHB concentration ⩾ 0.20 mmol/l. However, even with elevated concentrations of milk BHB, a blood test and/or a veterinary visit is necessary to help on the diagnosis of HYK.…”

Section: Referencesmentioning

confidence: 99%

Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance

Benedet

Manuelian

Zidi

et al. 2019

animal

View full text Add to dashboard Cite

Hyperketonemia (HYK) is one of the most frequent and costly metabolic disorders in high-producing dairy cows and its diagnosis is based on β-hydroxybutyrate (BHB) concentration in blood. In the last 10 years, the number of papers that have dealt with the impact of elevated BHB levels in dairy cattle has increased. Therefore, this paper reviewed the recent literature on BHB concentration in blood and milk, and its relationships with dairy cow health and performance, and farm profitability. Most studies applied the threshold of 1.2 mmol/l of BHB concentration in blood to indicate HYK; several authors considered BHB concentrations between 1.2 and 2.9 mmol/l as subclinical ketosis, and values ⩾3.0 mmol/l as clinical ketosis. Results on HYK frequency (prevalence and incidence) and cow performance varied according to parity and days in milk, being greater in multiparous than in primiparous cows, and in the first 2 weeks of lactation than in later stages. Hyperketonemia has been associated with greater milk fat content, fat-to-protein ratio and energy-corrected milk, and lower protein and urea nitrogen in milk. The relationships with milk yield and somatic cell count are still controversial. In general, HYK impairs health of dairy cows by increasing the risk of the onset of other early lactation diseases, and it negatively affects reproductive performance. The economic cost of HYK is mainly due to impaired reproductive performance and milk loss. From a genetic point of view, results from the literature suggested the feasibility of selecting cows with low susceptibility to HYK. The present review highlights that milk is the most promising matrix to identify HYK, because it is easy to sample and allows a complete screening of the herd through BHB concentration predicted using mid-IR spectroscopy during routine milk recording. Further research is needed to validate accurate and convenient methods to discriminate between cows in risk of HYK and healthy animals in field conditions and to support farmers to achieve an early detection and minimise the economic losses.

show abstract

“…The heritability estimate for BHB concentration was close to 0, in agreement with reports from several previous studies. Lee et al (2016), for instance, reported heritability values ranging between 0.04 and 0.17 for milk BHB in Korean Holstein cows, depending on parity and stage of lactation. Similarly, heritability values ranging between 0.07 and 0.29 were reported for milk BHB in several other studies for different breeds of cattle (van der Drift et al, 2012;Koeck et al, 2014;Penasa et al, 2015;Jamrozik et al, 2016).…”

Section: Effects Of Host Genetics and Rumen Microbiome In Milk Metabomentioning

confidence: 99%

Predictive ability of host genetics and rumen microbiome for subclinical ketosis

Gebreyesus

Difford

Buitenhuis

et al. 2020

Journal of Dairy Science

View full text Add to dashboard Cite

Genetic Parameters of Milk β-Hydroxybutyric Acid and Acetone and Their Genetic Association with Milk Production Traits of Holstein Cattle

Cited by 17 publications

References 24 publications

Genetic parameters for endocrine and traditional fertility traits, hyperketonemia and milk yield in dairy cattle

Genetic parameters for endocrine and traditional fertility traits, hyperketonemia and milk yield in dairy cattle

Invited review: β-hydroxybutyrate concentration in blood and milk and its associations with cow performance

Predictive ability of host genetics and rumen microbiome for subclinical ketosis

Contact Info

Product

Resources

About