Genetic markers of inflammation may not contribute to metabolic traits in Mexican children

Abstract

Background: Low-grade chronic inflammation is a common feature of obesity and its cardio-metabolic complications. However, little is known about a possible causal role of inflammation in metabolic disorders. Mexico is among the countries with the highest obesity rates in the world and the admixed Mexican population is a relevant sample due to high levels of genetic diversity.Methods: Here, we studied 1,462 Mexican children recruited from Mexico City. Six genetic variants in five inflammation-related genes were genotyped: rs1137101 (leptin receptor (LEPR)), rs7305618 (hepatocyte nuclear factor 1 alpha (HNF1A)), rs1800629 (tumor necrosis factor alpha (TNFA)), rs1800896, rs1800871 (interleukin-10 (IL-10)), rs1862513 (resistin (RETN)). Ten continuous and eight binary traits were assessed. Linear and logistic regression models were used adjusting for age, sex, and recruitment centre.Results: We found that one SNP displayed a nominal evidence of association with a continuous trait: rs1800871 (IL-10) with LDL (beta = −0.068 ± 1.006, P = 0.01). Subsequently, we found one nominal association with a binary trait: rs7305618 (HNF1A) with family history of hypertension (odds-ratio = 1.389 [1.054–1.829], P = 0.02). However, no P-value passed the Bonferroni correction for multiple testing.Discussion: Our data in a Mexican children population are consistent with previous reports in European adults in failing to demonstrate an association between inflammation-associated single nucleotide polymorphisms (SNPs) and metabolic traits.

Polymorphisms in Adipokines in Mexican Children with Obesity

“…Our results are consistent with three studies in Mexican children that showed no contribution of several polymorphisms in ADIPOQ gene (rs2241766, rs182052, rs266729, and rs822393) in children obesity [9, 20, 21]. A similar effect was observed in TNF-α and interleukin-10 [22], suggesting that genetic variants in adipokines do not have a significant effect in Mexican-Mestizo children obesity.…”

Prevalencia De Síndrome Metabólico en Niños Y Adolescentes De América

“…Los datos reportados son el resultado del análisis de 23 artículos que cumplieron con los criterios de inclusión, y que corresponden a 12 países de América: Argentina [15][16][17][18] , Brasil 19 , Canadá [20][21] , Chile [22][23][24] , Colombia [25][26][27] , Ecuador 28 , Estados Unidos de América (EUA) 29 , Guatemala 30 , México [31][32][33][34] , Paraguay 35 , Perú 36 y Venezuela 37 . Del total de estudios analizados, solamente 21 trabajos mostraron prevalencias generales de obesidad abdominal, 18 de ellos tuvieron prevalencias de hiperglucemia, otros 18 indicaron las prevalencias de hipertrigliceridemia, 19 las prevalencias de hipoalfalipoproteinemia (HDL-C bajo), 20 más midieron prevalencias de hipertensión arterial, y 18 analizaron prevalencias del SM.…”

Adiponectin is associated with cardio-metabolic traits in Mexican children

“…Limitations include the selection of ADIPOQ , ADIPOR1 , and ADIPOR2 SNPs which was not exhaustive and did not include more recent GWAS discoveries 22,73 . Our study is also modestly powered to identify genetic effects, especially after adjusting for multiple testing correction 74 . Study participants were randomly selected from Mexico City and is therefore representative of the urban population of central Mexico, not of the Mexican population as a whole.…”