Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17

Fisher, Simon; Beever, J. E.; Lewin, Harris A.

doi:10.1111/j.1365-2052.1997.00131.x

Cited by 7 publications

(7 citation statements)

References 17 publications

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“…Located just distal to the centromere of BTA17, BB718 designates a breakpoint for a conserved segment corresponding to HSA4q25-q31. Mapping studies that previously defined this comparative genomic conservation revealed that the bovine orthologs for interleukin 2 and 15 and uncoupling protein 1 mapped to BTA17 in reverse gene order with respect to the centromere (Fisher et al 1997; Sonstegard unpublished; Sonstegard and Kappes 1999b, respectively).…”

Section: Discussionmentioning

confidence: 89%

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL

et al. 2000

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Sonstegard, Tad S.; Garrett, Wes M.; Ashwell, Melissa S.; Bennett, Gary L.; Kappes, Steven M.; and Van Tassell, Curtis P., "Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL" (2000). Abstract. Quantitative trait loci (QTL) associated with fat deposition have been identified on bovine Chromosome 27 (BTA27) in two different cattle populations. To generate more informative markers for verification and refinement of these QTL-containing intervals, we initiated construction of a BTA27 comparative map. Fourteen genes were selected for mapping based on previously identified regions of conservation between the cattle and human genomes. Markers were developed from the bovine orthologs of genes found on human Chromosomes 1 (HSA1), 4, 8, and 14. Twelve genes were mapped on the bovine linkage map by using markers associated with single nucleotide polymorphisms or microsatellites. Seven of these genes were also anchored to the physical map by assignment of fluorescence in situ hybridization probes. The remaining two genes not associated with an identifiable polymorphism were assigned only to the physical map. In all, seven genes were mapped to BTA27. Map information generated from the other seven genes not syntenic with BTA27 refined the breakpoint locations of conserved segments between species and revealed three areas of disagreement with the previous comparative map. Consequently, portions of HSA1 and 14 are not conserved on BTA27, and a previously undefined conserved segment corresponding to HSA8p22 was identified near the pericentromeric region of BTA8. These results show that BTA27 contains two conserved segments corresponding to HSA8p, which are separated by a segment corresponding to HSA4q. Comparative map alignment strongly suggests the conserved segment orthologous to HSA8p21-q11 contains QTL for fat deposition in cattle.

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Section: Discussionmentioning

confidence: 89%

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL

et al. 2000

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“…Nine bulls that sire paternal half-sib families collectively known as the Illinois Reference and Resource Families (IRRF; [22]) were screened for a polymorphism in bPOU5F1 by single-strand conformational polymorphism (SSCP) analysis as described [23]. Polymerase chain reaction (PCR) products for SSCP analysis were generated using oligonucleotide primers OCT27 (5Ј-GGAAATTGGGAACACAATGGG-3Ј, coding strand) and OCT28 (5Ј-AACAGCAACCTTCGT-TTCGG-3Ј, noncoding strand), which are both located downstream of the predicted stop codon of bPOU5F1 (see Fig.…”

Section: Genetic Mapping Of Bpou5f1mentioning

confidence: 99%

Molecular Cloning, Genetic Mapping, and Developmental Expression of Bovine POU5F11

Eijk¹,

Rooijen²,

Modina³

et al. 1999

Biology of Reproduction

166

117

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We describe isolation and characterization of the bovine ortholog of POU5F1 (bPOU5F1) encoding octamer-binding transcription factor-4 (Oct-4). The organization of bPOU5F1 is similar to its human and murine orthologs, and it shares 90.6% and 81.7% overall identity at the protein level, respectively. Transient transfection of luciferase reporter constructs in murine P19 embryonal carcinoma cells demonstrated that bPOU5F1 has a functional promoter and contains two enhancer elements, of which one is repressed by retinoic acid. bPOU5F1 was mapped to the major histocompatibility complex on chromosome 23. bPOU5F1 mRNA was detected by nested reverse transcription-polymerase chain reaction in immature oocytes and in in vitro-produced preattachment-stage embryos. Oct-4 in oocytes and in vitro-produced preattachment-stage embryos was demonstrated by indirect immunofluorescence. Confocal laser scanning microscopy revealed Oct-4 in both the inner cell mass and trophoblast cells of the blastocyst until Day 10 of development. Immunofluorescence performed on the outgrowths formed at Day 13 postfertilization from in vitro-produced Day 8 blastocysts showed Oct-4 staining in all cells. This expression pattern suggests that bPOU5F1 acts early in bovine embryonic development but that its expression is not restricted to pluripotent cells of the blastocyst.

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“…The author found a QTL for live weight maps between markers BM1258 and BoLA DRBP on chromosome 23. (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) and the distance (in cM, relative positions) between them. BMS2508, BM3026 and TGLA37 (in bold) are the significant effect markers on daily body weight gain trait (DBWG).…”

Section: Discussionmentioning

confidence: 99%

Mapping of quantitative trait loci influencing daily body weight gain (DBWG) on chromosome 6 in German Holstein population

et al. 2006

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Twelve microsatellite markers on chromosome 6 were analyzed in German Holstein population to detect and locate QTL affecting daily body weight gain (DBWG). The results indicate promising location for QTL controlling daily body weight gain trait on chromosome 6. Where, three markers BMS2508 BM3026 and TGLA37 at three different positions in a distance 15.2 cM on BTA6 were associated with significant effects for daily body weight gain trait (DBWG). Comparison between this finding and previously identified QTL support the location of a QTL for growth traits on chromosome 6, where a significant QTL for birth and yearling weight was previously identified on chromosome 6 tightly close to marker BM3026. Finding from this study could be used in subsequent fine-mapping work and applied to marker-assisted selection (MAS) of production traits.

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Genetic mapping of five human chromosome 4 orthologues to bovine chromosomes 6 and 17

Cited by 7 publications

References 17 publications

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL

Comparative map alignment of BTA27 and HSA4 and 8 to identify conserved segments of genome containing fat deposition QTL

Molecular Cloning, Genetic Mapping, and Developmental Expression of Bovine POU5F11

Mapping of quantitative trait loci influencing daily body weight gain (DBWG) on chromosome 6 in German Holstein population

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