Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Wang, Xiaoling; Ding, Xiuhua; Su, Shaoyong; Harshfield, Gregory A.; Treiber, Frank A.; Snieder, Harold

doi:10.1038/hr.2010.218

Cited by 29 publications

(25 citation statements)

References 48 publications

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“…This is consistent with prior research showing increased MI risk associated with L genotypes in 4 White samples 41,42,44,45 and suggests – not surprisingly, given the low proportion of the rs25531 G allele in L alleles among Whites 49 – that this increased risk will be present in Whites using either diallelic or triallelic 5HTTLPR genotypes. It is also consistent with recent research suggesting that “substantial overlap exists between genes that influence BP measured in the office, under laboratory stress and during real life.” 62 We detected no association with DBP in Whites.…”

Section: Discussioncontrasting

confidence: 53%

Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Williams

Bishop

Haberstick

et al. 2017

American Heart Journal

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Background Based on prior research finding the 5HTTLPR L allele associated with increased cardiovascular reactivity to laboratory stressors and increased risk of myocardial infarction, we hypothesized that the 5HTTLPR L allele will be associated with increased blood pressure (BP) and increased hypertension prevalence in 2 large nationally representative samples in the United States and Singapore. Methods Logistic regression and linear models tested associations between triallelic (L’S’, based on rs25531) 5HTTLPR genotypes and hypertension severity and mean systolic and diastolic blood pressure (SBP and DBP) collected during the Wave IV survey of the National Longitudinal Study of Adolescent to Adult Health (Add Health, N = 11,815) in 2008–09 and during 2004–07 in 4196 Singaporeans. Results In US Whites, L’ allele carriers had higher SBP (0.9 mm Hg, 95% CI = 0.26–1.56) and greater odds (OR = 1.23, 95% CI = 1.10–1.38) of more severe hypertension than those with S’S’ genotypes. In African Americans, L’ carriers had lower mean SBP (−1.27 mm Hg, 95% CI = −2.53 to −0.01) and lower odds (OR = 0.78, 95% CI = 0.65–0.94) of more severe hypertension than those with the S’S’ genotype. In African Americans, those with L’L’ genotypes had lower DBP (−1.13 mm Hg, 95% CI = −2.09 to −0.16) than S’ carriers. In Native Americans, L’ carriers had lower SBP (−6.05 mm Hg, 95% CI = −9.59 to −2.51) and lower odds of hypertension (OR = 0.34, 95% CI = 0.13–0.89) than those with the S’S’ genotype. In Asian/Pacific Islanders those carrying the L’ allele had lower DBP (−1.77 mm Hg, 95% CI = −3.16 to −0.38) and lower odds of hypertension (OR = 0.68, 95% CI = 0.48–0.96) than those with S’S’. In the Singapore sample S’ carriers had higher SBP (3.02 mm Hg, 95% CI = 0.54–5.51) and DBP (1.90 mm Hg, 95% CI = 0.49–3.31) than those with the L’L’ genotype. Conclusions These findings suggest that Whites carrying the L’ allele, African Americans and Native Americans with the S’S’ genotype, and Asians carrying the S’ allele will be found to be at higher risk of developing cardiovascular disease and may benefit from preventive measures.

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Section: Discussioncontrasting

confidence: 53%

Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Williams

Bishop

Haberstick

et al. 2017

American Heart Journal

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“…Heritability estimates derived from twin studies tend to be higher than those obtained from family studies [3,25,26]. Heritability of 24-h ambulatory SBP and DBP can be as high as 0.71 for SBP and 0.69 for DBP [3].…”

Section: Discussionmentioning

confidence: 93%

“…Hypertension results from a complex interplay between genetic and environmental factors, and previous studies have demonstrated that up to 50% of blood pressure (BP) variance can be explained by genetic factors [3]. Estimating the heritability of a trait is of interest as it represents one of the first steps in the gene-mapping process [4].…”

Section: Introductionmentioning

confidence: 99%

Heritability of ambulatory and office blood pressure in the Swiss population

Alwan

Ehret²,

Ponte

et al. 2015

Journal of Hypertension

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a Background: Blood pressure (BP) is known to aggregate in families. Yet, heritability estimates are populationspecific and no Swiss data have been published so far. We estimated the heritability of ambulatory and office BP in a Swiss population-based sample. Methods: The Swiss Kidney Project on Genes inHypertension is a population-based family study focusing on BP genetics. Office and ambulatory BP were measured in 1009 individuals from 271 nuclear families. Heritability was estimated for SBP, DBP, and pulse pressure using a maximum likelihood method implanted in the Statistical Analysis in Genetic Epidemiology software. Results:The 518 women and 491 men included in this analysis had a mean (AESD) age of 48.3 (AE17.4) and 47.3 (AE17.7) years, and a mean BMI of 23.8 (AE4.2) and 25.9 (AE4.1) kg/m 2 , respectively. Narrow-sense heritability estimates (AEstandard error) for ambulatory SBP, DBP, and pulse pressure were 0.37 AE 0.07, 0.26 AE 0.07, and 0.29 AE 0.07 for 24-h BP; 0.39 AE 0.07, 0.28 AE 0.07, and 0.27 AE 0.07 for day BP; and 0.25 AE 0.07, 0.20 AE 0.07, and 0.30 AE 0.07 for night BP, respectively (all P < 0.001). Heritability estimates for office SBP, DBP, and pulse pressure were 0.21 AE 0.08, 0.25 AE 0.08, and 0.18 AE 0.07 (all P < 0.01). Conclusions:We found significant heritability estimates for both ambulatory and office BP in this Swiss populationbased study. Our findings justify the ongoing search for the genetic determinants of BP.

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“…1 In addition, height, weight, and waist circumference were taken using standard measurement protocols. 25,26 ambulatory BP evaluations…”

Section: Physiologic Measurementsmentioning

confidence: 99%

mHealth medication and blood pressure self-management program in Hispanic hypertensives: a proof of concept trial

Sieverdes

Gregoski²,

Patel³

et al. 2013

SHTT

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Genetic influence on blood pressure measured in the office, under laboratory stress and during real life

Cited by 29 publications

References 48 publications

Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence

Heritability of ambulatory and office blood pressure in the Swiss population

mHealth medication and blood pressure self-management program in Hispanic hypertensives: a proof of concept trial

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