Genetic influence on auditory information processing in schizophrenia: P300 in monozygotic twins

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400

“…Moreover, the latter two groups did not differ on this measure. Other studies of the unaffected siblings of patients have also reported changes in auditory P300, with reduced amplitude at temporo-parietal sites and increased amplitude at frontal P300 sites (Roxborough et al, 1993;Weisbrod et al, 1999). These variables may be quantitative endophenotypes associated with increased genetic risk for schizophrenia, and may be useful in genetic studies of schizophrenia (Price et al, 2006;Winterer et al, 2003).…”

Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer?

“…Studies in twin samples confirm that P300 amplitude is a highly heritable human characteristic. 13 In terms of brain structure, brain volume is highly heritable, 14 and neocortical gray matter volumes are heritable and correlate with multiple cognitive domains; 15 hippocampal, neocortical and cortical volume deficits have also been observed to be related to genetic risk for schizophrenia in family-based studies. 5,[16][17][18] Thus, for many biological changes related to brain function and structure that are associated with schizophrenia and with increased genetic risk for schizophrenia, the evidence for their heritability is strong.…”

White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI–EEG study

“…[13][14][15] P300 can index a neuro biologic vulnerability to schizophrenia, in line with other studies showing P300 abnormalities in relatives of individuals with psychosis. 16,17 On the other hand, neuroimaging studies have indicated that patients at high risk for psychosis show alterations in white matter 18,19 volume in fronto-temporal regions. In particular, the first study exploring white matter in the prepsychotic phases found reduced temporal lobe volume in patients at increased clinical risk for psychosis.…”