Genetic evolution of influenza viruses among selected countries in Latin America, 2017–2018

Leite, Juliana Almeida; Resende, Paola Cristina; Araya, Jenny Lara; Barrera, Gisela; Baumeister, Elsa; Bruno, Alfredo; Cóppola, Leticia; Mello, Wyller Alencar de; Mora, Doménica de; Santos, Mirleide Cordeiro dos; Fasce, Rodrigo; Fernández, Jorge Onrubia; Goñi, Natalia; Martínez-Carrillo, Irma; Mayhua, Jannet Otárola; Motta, Fernando Couto; Huaringa, Maribel; Ojeda, Jenny; Ortega, María José Cilleruelo; Ospitia, Erika; Paiva, Terezinha Maria de; Pontoriero, Andrea; Porras, Hebleen Brenes; Quiñonez, José Alberto Díaz; Ramas, Viviana; Ramirez, Juliana Barbosa; Santos, Katia Corrêa de Oliveira; Siqueira, Marilda Mendonça; Vázquez, Cynthia; Palekar, Rakhee

doi:10.1371/journal.pone.0227962

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…These labs provide information about genetic evolution and patterns for Influenza A and B viruses. Data obtained from 2010–2018 have shown that vaccination plans in LAC tend to correlate with genetic findings of circulating influenza virus in the region, although the characteristics of seasonal subtype of the virus are unevenly reported across countries [ 50 , 54 , 56 ].…”

Section: Resultsmentioning

confidence: 99%

“…The year-to-year evolution of circulating influenza viruses is certainly the biggest obstacle for control, thus continuous diagnosis and sample sequencing is key to update running vaccination plans. Between 2017 and 2018, 12 NICs reported that results from samples taken in LAC matched global patterns and were fully covered by the vaccine recommended virus; even though H3 clades not associated with the vaccine recommended virus were found, studies have shown cross-reaction using trivalent vaccine viruses against this HA [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

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Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review

Alvarez-Munoz

Upegui-Porras

Gómez

et al. 2021

Viruses

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Viruses play a primary role as etiological agents of pandemics worldwide. Although there has been progress in identifying the molecular features of both viruses and hosts, the extent of the impact these and other factors have that contribute to interspecies transmission and their relationship with the emergence of diseases are poorly understood. The objective of this review was to analyze the factors related to the characteristics inherent to RNA viruses accountable for pandemics in the last 20 years which facilitate infection, promote interspecies jump, and assist in the generation of zoonotic infections with pandemic potential. The search resulted in 48 research articles that met the inclusion criteria. Changes adopted by RNA viruses are influenced by environmental and host-related factors, which define their ability to adapt. Population density, host distribution, migration patterns, and the loss of natural habitats, among others, have been associated as factors in the virus–host interaction. This review also included a critical analysis of the Latin American context, considering its diverse and unique social, cultural, and biodiversity characteristics. The scarcity of scientific information is striking, thus, a call to local institutions and governments to invest more resources and efforts to the study of these factors in the region is key.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review

Alvarez-Munoz

Upegui-Porras

Gómez

et al. 2021

Viruses

View full text Add to dashboard Cite

show abstract

“…The use of this strategy has also been a useful tool for public health response regarding disease control. Among respiratory viruses, influenza virus is a classic example on how genetic characterization and phylogenetic analysis have been combined for influenza mitigation by providing information for vaccine compositions, molecular diagnostic protocols, antiviral development, monitoring of antiviral resistance and studies on viral lineage and molecular epidemiology [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Implementation of a COVID-19 Genomic Surveillance Regional Network for Latin America and Caribbean region

et al. 2022

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The timely release of SARS-CoV-2 first genomic sequences allowed the identification of the etiologic agent and development of diagnostic protocols. Genomic sequencing was a crucial step in generating data for driving laboratory response and detections of SARS-CoV-2 since the start of the COVID-19 pandemic. Because of all the progression and achievements that timely release of genetic sequence data represents in the public health response, the Pan American Health Organization (PAHO) in collaboration with countries’ public health laboratories, started implementation of a network for strengthening the Latin America and Caribbean (LAC) region on timely generation of SARS-CoV-2 genomic data. Here we describe the implementation of the COVID-19 Genomic Surveillance Regional Network in the Americas region during the beginning of the pandemic. The establishment of this network has strengthened laboratory response capacity at the country level, as well as facilitated timely release of SARS-CoV-2 genomic information to be used to complement the multiple response strategies for COVID-19 pandemic mitigation. As genomic epidemiology is useful for guiding public health decisions on outbreak and response, we also analysed the first SARS-CoV-2 genomic sequence data from countries of the Latin America and Caribbean Region.

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Effectiveness of Maternal Influenza Vaccination in Peru PRIME Cohort

Owusu

Dawood

Azziz‐Baumgartner

et al. 2023

Open Forum Infectious Diseases

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Background Few studies have examined influenza vaccine effectiveness (VE) among women during pregnancy in middle-income countries. We used data from a prospective cohort of women who were pregnant in Peru to estimate effectiveness of the 2018 Southern Hemisphere influenza vaccine. Methods Women at <28 weeks gestation were enrolled from four tertiary level hospitals in Lima, Peru at the start of the 2018 influenza season and followed until the end of their pregnancies. Participants had mid-turbinate nasal swabs collected and tested for influenza by RT-PCR with onset of >1 of myalgia, cough, runny nose or nasal congestion, sore throat, or difficulty breathing. Time-varying Cox proportional hazard regression models were used to estimate the risk of RT-PCR-confirmed influenza infection after adjusting for inverse probability treatment weight. Results We followed 1,896 women for a median of 127 days (IQR; 86-174). Participants had a median age of 29 years (IQR: 24–34). Among the 1,896 women, 49% were vaccinated with the 2018 influenza vaccine and 1,039 (55%) developed influenza-like illness of which, 76 (7%) had RT-PCR-confirmed influenza. Incidence rates of RT-PCR-confirmed influenza were 36.6 and 15.3 per 100,000 person-days among women who were unvaccinated and vaccinated, respectively. Adjusted influenza VE was 22% (95% CI: -64.1%, 62.9%). Conclusion Participants vaccinated against influenza had more than 50% lower incidence of RT-PCR-confirmed influenza illness. While the VE estimated through propensity weight-adjusted time-varying Cox regression did not reach statistical significance, our findings provide additional evidence about the value of maternal influenza vaccination in middle-income countries.

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Genetic evolution of influenza viruses among selected countries in Latin America, 2017–2018

Cited by 3 publications

References 9 publications

Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review

Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review

Implementation of a COVID-19 Genomic Surveillance Regional Network for Latin America and Caribbean region

Effectiveness of Maternal Influenza Vaccination in Peru PRIME Cohort

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