Genetic evaluation of the serotonergic system in chronic fatigue syndrome

Smith, Alicia K.; Dimulescu, Irina; Falkenberg, Virginia R.; Narasimhan, Supraja; Heim, Christine; Vernon, Suzanne D.; Rajeevan, Mangalathu S.

doi:10.1016/j.psyneuen.2007.11.001

Cited by 61 publications

(72 citation statements)

References 74 publications

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“…This is similar to what has been reported for SNPs in terms of predisposition to psoriasis and for disease subtype (Reich et al, 2002;Nedoszytko et al, 2007;Wongpiyabovorn et al, 2008a,b;Wu et al, 2009). The -1438A allele may contribute to disease susceptibility because it is associated with increased 5-HTR2A expression (Parsons et al, 2004); this is also supported by bioinformatics studies (Smith et al, 2008). However, the molecular impact of this particular allele has been demonstrated to be modulated by another SNP of this gene, -783A/G (Myers et al, 2007).…”

Section: Discussionsupporting

confidence: 86%

“…In contrast, the former SNP has been shown to transcriptionally modulate 5-HTR2A gene expression (Parsons et al, 2004;Myers et al, 2007). In addition, in silico analysis of -1438A/G allelic variants has revealed the A allele, which contains a consensus binding site for transcription factor Th1/E47; also an electrophoretic mobility shift assay successfully demonstrated allele-specific binding to support the bioinformatics predictions (Smith et al, 2008). Differences in disease susceptibility may be due to altered density of the receptor crucial for neurotransmitter mechanisms, making this SNP a promising candidate for an association study.…”

Section: Introductionmentioning

confidence: 73%

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Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

Ronpirin¹,

Tencomnao²,

Wongpiyabovorn³

2010

Genet. Mol. Res.

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ABSTRACT. Expression of serotonin 2A receptor (5-HTR2A) is known to increase in psoriasis, a chronic inflammatory skin disease. We investigated a possible association between the -1438A/G single nucleotide polymorphism (rs6311) in the promoter region of 5-HTR2A gene and psoriasis in a Thai population. One hundred and twelve psoriatic patients and 151 unrelated healthy controls were included in our study. Genotyping was performed using the polymerase chain reaction and restriction fragment length polymorphism techniques. We found no overall differences in genotype distributions and allele frequencies when comparing between the two groups. When we analyzed a subset of psoriatic patients classified by onset and severity, only the -1438A allele was significantly increased in patients with lateonset psoriasis when compared with the healthy control group (c 2 = 4.77, d.f. = 1, P = 0.029, odds ratio = 2.298 [95% confidence interval =

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 73%

Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

Ronpirin¹,

Tencomnao²,

Wongpiyabovorn³

2010

Genet. Mol. Res.

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“…On the contrary, rs6311 has been shown to transcriptionally modulate the expression of this gene (Parsons et al, 2004;Myers et al, 2007). Consistently, in silico analysis has found the potential function of the rs6311 A allele due to its possession of a consensus binding site for transcription factor Th1/E47, and allele-specific binding has been reported using an electrophoretic mobility shift assay (Smith et al, 2008). Furthermore, this allele has been shown to be associated with increased 5-HTR2A receptor binding (Turecki et al, 1999).…”

Section: Introductionmentioning

confidence: 71%

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Tencomnao¹,

Thongrakard²,

Phuchana³

et al. 2010

Genet. Mol. Res.

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ABSTRACT. Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study. We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP. We found no significant differences between the two groups with

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“…15,16 The rs6313 single nucleotide polymorphism (SNP) was found to be associated with fibromyalgia, depression, chronic fatigue syndrome, and chronic widespread pain syndrome. 8,[17][18][19][20] Depression is a common form of psychological disturbance seen in patients with CLBP, and it is an important factor associated with disability in this patient cohort. 21,22 The patients with a history of major depressive disorder, chronic widespread pain syndrome, and fibromyalgia were excluded from this study, thus the findings may not be attributable to these disorders.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism

et al. 2017

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Objectives: This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences. Patients and methods: A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body. Results:The PPTs were all decreased in CLBP patients (p<0.05). Although PPTs were lower in healthy female individuals, there was no sex difference regarding PPTs in CLBP patients (p>0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p<0.05). In rs6313 polymorphism, at least one copy of T carriers and in rs6311 polymorphism, at least one copy of G carriers showed higher disability. Conclusion: The PPT decreases in CLBP patients similar to other chronic pain conditions without any sex difference. Although rs6311 single nucleotide polymorphism of HTR2A gene was associated with CLBP and rs6313 polymorphism was not, rs6311 might have a protective effect on disability of these patients.

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Genetic evaluation of the serotonergic system in chronic fatigue syndrome

Cited by 61 publications

References 74 publications

Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

Association between the -1438A/G polymorphism of the serotonin 2A receptor gene and late-onset psoriasis in a Thai population

No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population

Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism

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