Assessment of Pain Sensitivity in Patients With Chronic Low Back Pain and Association With HTR2A Gene Polymorphism

Abstract

Objectives: This study aims to investigate the association of two common HTR2A gene polymorphisms, rs6313 (102 T/C) and rs6311 (1438 A/G), with chronic low back pain (CLBP) and the pain threshold, disability, and sex differences. Patients and methods: A total of 121 patients (40 males, 81 females; mean age 36.8±9.9 years; range 18 to 50 years) having CLBP and 91 healthy controls (26 males, 65 females; mean age 34.1±10.2 years; range 18 to 55 years) were included. Pressure pain thresholds (PPTs) of all participants were examined with manual algometer in certain sites of their body. Results:The PPTs were all decreased in CLBP patients (p<0.05). Although PPTs were lower in healthy female individuals, there was no sex difference regarding PPTs in CLBP patients (p>0.05). rs6311 polymorphism of HTR2A gene was associated with CLBP (p<0.05). In rs6313 polymorphism, at least one copy of T carriers and in rs6311 polymorphism, at least one copy of G carriers showed higher disability. Conclusion: The PPT decreases in CLBP patients similar to other chronic pain conditions without any sex difference. Although rs6311 single nucleotide polymorphism of HTR2A gene was associated with CLBP and rs6313 polymorphism was not, rs6311 might have a protective effect on disability of these patients.

Can Implementation of Genetics and Pharmacogenomics Improve Treatment of Chronic Low Back Pain?

“…HTR2A gene polymorphisms rs6311 and rs6313 were found to be associated with higher disability, as measured by ODI (Oswestry Disability index) [18]. Polymorphism rs6311 (1438 A/G) was associated with chronic LBP, but patients with genotypes AA and AG had greater ODI scores [18]. Likewise, patients with TT or TC genotypes in rs6313 (102 T/C) polymorphism had higher ODI scores, but these genotypes were not associated with cLBP [18].…”

“…Research has shown the associations between being susceptible to chronic pain conditions (e.g., chronic widespread pain and fibromyalgia) and serotonin receptor 2A (HTR2A) gene polymorphisms [17]. HTR2A gene polymorphisms rs6311 and rs6313 were found to be associated with higher disability, as measured by ODI (Oswestry Disability index) [18]. Polymorphism rs6311 (1438 A/G) was associated with chronic LBP, but patients with genotypes AA and AG had greater ODI scores [18].…”

Análise de polimorfismos de nucleotídeo único na cistite intersticial

“…Existem evidências na literatura de que algumas alterações genéticas nas vias serotoninérgicas também possam estar associadas à patogênese de síndromes dolorosas crônicas (70) . Os polimorfismos no gene do receptor de serotonina (5HT-2A) têm sido associados a essas síndromes dolorosas crônicas, como a FM e a vestibulodínea (70,71) .…”

“…Os polimorfismos no gene do receptor de serotonina (5HT-2A) têm sido associados a essas síndromes dolorosas crônicas, como a FM e a vestibulodínea (70,71) . O SNP rs6311 analisado por nós está associado ao receptor de serotonina (71) .…”

“…Embora não existam trabalhos na literatura associando este SNP com CI, estudos mostram que a presença do alelo polimórfico do SNP rs6311 foi maior em pacientes com vestibulodínea e também maior nas pacientes com dispareunia e dores no corpo concomitantes corroborando os nossos achados (70,71) . O polimorfismo rs1799971 já foi avaliado em diversos estudos de dor, devido a sua relação com os opióides e a sua alta frequência em diversas etnias, chegando a 10-15% em caucasianos e até a 50% em asiáticos.…”