Genetic epidemiology of stuttering among school children in the state of Tamil Nadu, India

Devi, G. Nandhini; Thalamuthu, Anbupalam; Valarmathi, S; Karthikeyen, N. P.; Srisailapathy, C. R. Srikumari

doi:10.1016/j.jfludis.2018.10.001

Cited by 10 publications

(6 citation statements)

References 40 publications

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“…The average prevalence over the lifespan may be lower than the commonly cited 1% 5 . In a recent study based on 75 000 school children in south India, we reported a prevalence of 0.46% 6 …”

Section: Introductionmentioning

confidence: 55%

Evaluation of recurrent GNPTAB, GNPTG, and NAGPA variants associated with stuttering

et al. 2021

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Stuttering is a childhood‐onset fluency disorder, intertwined with physiological, emotional, and anxiety factors. The present study was designed to evaluate the recurrence of the reported mutations among three previously implicated (GNPTAB, GNPTG, NAGPA) candidate genes, in persons with stuttering from south India. Mutation screening was performed among 64 probands on 12 specific exons, by Sanger sequencing. A total of 12 variants were identified, which included five nonsynonymous, five synonymous, and two noncoding variants. Three unrelated probands harbored heterozygous missense variants at conserved coding positions across species (p. Glu1200Lys in GNPTAB, p. Ile268Leu in GNPTG and p. Arg44Pro in NAGPA). Of these, only one variant (p. Glu1200Lys in GNPTAB) cosegregated with the affected status while p. Ile268Leu in GNPTG gene was found to be a rare de novo variant. Although this study identified some previously reported variants that have been claimed to have a role in stuttering, we confirmed only one of these to be a likely causal de novo variant (p.Ile268Leu) in the GNPTG gene at an allele frequency of 0.8% (1/128) in the families with stuttering.

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“…The average prevalence over the lifespan may be lower than the commonly cited 1% 5 . In a recent study based on 75 000 school children in south India, we reported a prevalence of 0.46% 6 …”

Section: Introductionmentioning

confidence: 55%

Evaluation of recurrent GNPTAB, GNPTG, and NAGPA variants associated with stuttering

et al. 2021

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“…The cases reported in the present study included the states of Karnataka (90.4%), Tamil Nadu (2%), Kerala (6%), and Maharashtra (1.6%), covering most of the southern states of India. Other stud-ies conducted in the Indian context are few & one of them has estimated stuttering cases among school children in the Indian population (Tamil Nadu) as 0.46% [9]. Other studies conducted in the Indian context reported stuttering prevalence ranging from 0.4% to 1.5% within specific age groups and geographical locations [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…Other stud-ies conducted in the Indian context are few & one of them has estimated stuttering cases among school children in the Indian population (Tamil Nadu) as 0.46% [9]. Other studies conducted in the Indian context reported stuttering prevalence ranging from 0.4% to 1.5% within specific age groups and geographical locations [7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…A national survey conducted by National Sample Survey Organisation, India [7] reported that around 0.4% of the urban population was prone to stuttering. Within the psychiatric disorders, a prevalence rate of 1.5% was reported between the ages of 4 to 16 years in Bangalore, India and 0.46% with a male-to-female ratio of 4:1 in Tamil Nadu, India [8,9].…”

Section: Introductionmentioning

confidence: 99%

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Clinical Profiling of Stuttering Characteristics in a Speech Clinic of a Tertiary care Hospital- a Retrospective Study of the Decennial Trend

Kavya,

Veena,

Bellur

2023

Clin Arch Commun Disord

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Purpose: Stuttering is a speech disorder, which affects the smooth flow of speech with a worldwide prevalence rate of about 1%. Reports on the estimation of stuttering prevalence across all age groups based on various influential factors are limited. Clinical profiling of stuttering characteristics in a speech clinic of a tertiary care hospital using retrospective data of 10 years.Methods: The decennial trend of stuttering between January 2010 and December 2019 with a complete enumeration of stuttering cases across all ages reported in the tertiary care clinic were analysed retrospectively for various factors such as primary and secondary features, and associated deficits.Results: Overall prevalence rate over a 10-year period was estimated to be 4.7%. Descriptive data on characteristics and influential factors related to the occurrence of stuttering were profiled.Conclusions: This study can be used to understand the decadal trends in stuttering traits. Information about contributing factors can help take steps to prevent risk factors for stuttering. The findings of this study will allow SLPs to understand the need for better documentation and intervention strategies for this population.

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“…Наличие семейного заикания отмечено в 11%. Соотношение мальчиков к девочкам составляет 4:1 (Devi, Thalamuthu, Valarmathi et al 2018).…”

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Theoretical approaches to the study of stuttering

Nikolaeva

Karpova

2021

Comprehensive Child Studies

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Genetic epidemiology of stuttering among school children in the state of Tamil Nadu, India

Cited by 10 publications

References 40 publications

Evaluation of recurrent GNPTAB, GNPTG, and NAGPA variants associated with stuttering

Evaluation of recurrent GNPTAB, GNPTG, and NAGPA variants associated with stuttering

Clinical Profiling of Stuttering Characteristics in a Speech Clinic of a Tertiary care Hospital- a Retrospective Study of the Decennial Trend

Theoretical approaches to the study of stuttering

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