Genetic Ecology of Hypertension

Abstract

I. A comparative study has been made of a population genetically homogeneous 2. Individuals were 'marked' with common serologic major genes. 3. The predominant strength of the environmental factors was demonstrated by the observation that when maintaining the genetic factor constant, hypertension appeared in the more advanced ('acculturated') Lowland populations.4. The absence of hypertension was confirmed in Highland isolated primitive peoples.5. Blood pressure correlation between relatives varied significantly with changing ecosystems.6. The predominant strength of heredity was nevertheless demonstrated by the fact that in acculturated populations the genetic component of variance was found to be greater than the environmental one, and the dominant component accounted for nearly half the genetic variance.7. Hypertension appears in the Lowlands to be exclusively associated with some specific genotypes of the Rhesus and MN systems.8. The determination of blood pressure may be controlled by few major genes operating in given ecosystems under the permissiveness of environmental agents. living in two adjacent but strongly different ecosystems.

Prevalencia de diabetes tipo 2 y obesidad en dos poblaciones aborígenes de Chile en ambiente urbano

“…En ambos estudios las cifras son mayores a las reportadas por Cruz-Coke y cols en 1973 24 , quienes no encontraron hipertensión en el altiplano y determinaron una prevalencia del 3,8% en población Aymara de Azapa. A pesar de que en la actualidad se están utilizando puntos de corte más restrictivos para clasificar HTA, esta tendencia no hace más que confirmar una pionera hipótesis de Cruz-Coke y cols, que indicaba que la HTA se incrementaba cuando la población Aymara emigraba de regiones rurales a zonas más urbanizadas 25,26 .…”

Heterogeneity of the blood pressure distribution among Solomon Islands societies with increasing acculturation

“…For example, cardiovascular disease is cosmopolitan in distribution, but in studies of traditional societies with little Western influence and urbanization it is uncommon (Thomas, 1927;Donnison, 1929;Morse and Beh, 1937;Murrill, 1949;Whyte, 1958;Abbie and Schroder, 1960;Lowenstein, 1961;Maddocks, 1961;Mann et al, 1962Mann et al, , 1964Hoobler, 1965;Shaper et al, 1969;Burns-Cox and Maclean, 1970;Glanville and Geerdink, 1972;Truswell, 1972;Page et al, 1974;Prior et al, 1974;Oliver et al, 1975;Ward, 1983). Traditional societies subjected to increasing acculturation by migration to more accultured areas (Cruz-Coke et al, 1964;Prior et al, 1968;Marmot and Syme, 1976;Hanna and Baker, 1979;Ward et al, 1979;McGarvey et al, 1980;James et al, 1983;Poulter et al, 1985) or in situ changes in acculturation (Cruz-Coke et al, 1973;La-Barthe, 1973;Page, 1976Page, ,1980Cruz-Coke, 1987;Friedlaender and Page, 1987) often show an increase in BP, lipid levels, and incidence of cardiovascular disease. Crosssectional studies comparing island migrants versus nonmigrants (e.g., McGarvey and Baker, 1979;Ward, 1983) and studies of in situ acculturation (e.g., LaBarthe, 1973;…”

Biological variations associated with change in lifestyle among the pastoral and nomadic tribes of East Africa

“…Population studies on the effects of "western acculturation" in primitive societies have been carried out in many parts of the world--on Melanesian tribes from New Guinea (Maddocks, 1967) and the Solomon Islands (Page et al, 1974); Easter Islanders (Cruz-Coke et al, 1964); Polynesians from Tokelau Island (Prior et al, 1974); American Indians from Chile (Cruz-Coke et al, 1973), Brazil (Lowenstein, 1961) and Guatemala (Hoobler et aL, 1965); and the nomadic tribes of East Africa (Shaper et al, 1969;Day et aL, 1976). These studies have established that individuals who relinquish a tribal or traditional lifestyle for one of a more "western" nature Ann Hum Biol Downloaded from informahealthcare.com by Nyu Medical Center on 02/03/15…”