Genetic diversity of ORF3 and spike genes of porcine epidemic diarrhea virus in Thailand

Temeeyasen, Gun; Srijangwad, Anchalee; Tripipat, Thitima; Tipsombatboon, Pavita; Piriyapongsa, Jittima; Phoolcharoen, Waranyoo; Chuanasa, Taksina; Tantituvanont, Angkana; Nilubol, Dachrit

doi:10.1016/j.meegid.2013.11.001

Cited by 60 publications

(80 citation statements)

References 27 publications

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“…In comparison to the CV777 strain, the spike genes of the HUA-PED45 and -PED47 strains have two insertions of four (QGVN) and one (N) aa at amino acid positions 58 to 59 and 135 to 136 and deletions of two (GK) and one (Y) aa at amino acid positions 158 to 159 and 1194. This result is similar to those of previous studies, in which insertions and deletions were located in the hypervariable domain in the N-terminus of the S1 region [15,20]. By contrast, the strains from Quang Tri had no deletions or insertions of amino acids in the spike genes.…”

supporting

confidence: 91%

A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs

Kim

Lim

et al. 2015

Arch Virol

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Porcine epidemic diarrhea virus (PEDV) causes severe diarrhea and dehydration in suckling pigs and has caused high rates of death among piglets and substantial economic loss in Vietnam since 2009. To investigate the genotypes of prevailing PEDVs, intestinal and fecal samples from piglets from central and northern Vietnam were collected and analyzed. Phylogenetic analysis of the nucleotide sequences of complete spike genes of PEDVs from Vietnam resulted in the identification of two divergent groups. PEDVs (HUA-PED45 and HUA-PED47) belonged to the G2b group, along with Chinese, US, and Korean strains occurring at the end of 2010, in May 2013 and in November 2013, respectively. Six strains from the Quang Tri region were assigned to the G1b group, along with Chinese and US strains. The Vietnamese PEDVs detected in infected piglets had a nationwide distribution and belonged to the G2b and G1b genotypes.

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confidence: 91%

A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs

Kim

Lim

et al. 2015

Arch Virol

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“…PEDV is a devastating enteric disease that is characterized by vomiting, acute severe watery diarrhea and dehydration, which results in significant high mortality in piglets under 7 days of age (Temeeyasen et al, 2013). At present, PED disease has continued to causing severe economic losses in many Asian countries, including China, Korea, Japan and Thailand (Gao et al, 2013;Li et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Porcine epidemic diarrhea virus infection: Inhibition by polysaccharide from Ginkgo biloba exocarp and mode of its action

et al. 2015

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“…PEDV is a devastating enteric disease that is characterized by vomiting, acute severe watery diarrhea, and dehydration (2). PEDV infections can occur in pigs of all ages, but infections are most serious in piglets, with morbidity and mortality often reaching 100% (3).…”

Section: Introductionmentioning

confidence: 99%

Antiviral Activity ofCorylusheterophyllaFisch Against Porcine Epidemic Diarrhea Virus Infection

et al. 2016

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The porcine epidemic diarrhea virus (PEDV) has recently been shown to cause huge economic losses in the global pork industry. Our results demonstrated that the extract dose-dependently inhibited the replication of PEDV and reduced the visible cytopathic effect (CPE). Treatment with C. heterophylla Fisch extract resulted in marked reduction of PEDVinduced cytokine and chemokine expression. The antiviral activity of C. heterophylla Fisch extract on PEDV replication was found to be primarily exerted at the early stages after infection. Taken together, our data indicate that C. heterophylla Fisch extract may be a good therapeutic agent for use against PEDV and also a potential candidate to be evaluated against other human and animal coronaviruses.

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Genetic diversity of ORF3 and spike genes of porcine epidemic diarrhea virus in Thailand

Cited by 60 publications

References 27 publications

A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs

A novel strain of porcine epidemic diarrhea virus in Vietnamese pigs

Porcine epidemic diarrhea virus infection: Inhibition by polysaccharide from Ginkgo biloba exocarp and mode of its action

Antiviral Activity ofCorylusheterophyllaFisch Against Porcine Epidemic Diarrhea Virus Infection

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